Pattern of neurological complications of chronic myeloid leukaemia in Ilorin, Nigeria: A ten year review
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Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Faculty of Clinical Sciences, College of Medicine, Ambrose Alli University
Abstract
Aim and Objective: The study was carried out to document the pattern of neurological complications seen in
patients with chronic myeloid leukemia who were managed at the University of Ilorin Teaching Hospital, Ilorin
and compare with previous reports from other parts of Nigeria and elsewhere.
Materials and Methods: A ten year retrospective analysis of all cases of CML managed at the study centre
between January 2006 and December 2015 was carried out. Case folders of all patients diagnosed with CML
during the study period, and the Malignancy registers of the Haematology department were retrieved and
analyzed. Relevant information retrieved included age, gender, clinical features at presentation, laboratory
investigations, treatment regimen, and survival outcome among others.
Results: Thirty six (36) patients were diagnosed with CML during the study period. There were 21 (58.3%)
males and 15 (41.7%) females, giving a male: female ratio of 1.4:1.The mean age of the patients at diagnosis was
37.5 years (range, 11-75 years). Nine (25%) patients presented with various forms of neurological complications
and the mean WBC count in them was 383.2 x 109/L (280.5 601.0 x 109/L). Auditory complications were the
commonest neurological deficits found in 6(66.7%) of the 9 patients with neurological manifestations.
Conclusion: The neurological complications recorded in this study were similar to those reported in previous
studies from Nigeria and other countries. These complications need to be looked for at presentation and
adequately characterized as their presence could significantly influence the prognosis of the disease and decisions
on management modalities.
Description
Keywords
Pattern, Neurological, Complications, CML, Nigeria
Citation
Babatunde, A.S., Olawumi, H.O., Durotoye, I.A., Shittu, A.O., Sanni, E.O., & Oyeleke, S.A. (2018). Pattern of neurological complications of chronic myeloid leukaemia in Ilorin, Nigeria: A ten year review. Archives of Clinical Research. 6: 10 -16. https://aauekpoma.edu.ng/index.php?option=com_content&view=categories&id=62&Itemid=232