Pattern of neurological complications of chronic myeloid leukaemia in Ilorin, Nigeria: A ten year review

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dc.contributor.authorBabatunde, A.S.
dc.contributor.authorOlawumi, H.O.
dc.contributor.authorDurotoye, I.A.
dc.contributor.authorShittu, A.O.
dc.contributor.authorSanni, E.O.
dc.contributor.authorOyeleke, S.A.
dc.date.accessioned2020-05-25T14:13:36Z
dc.date.available2020-05-25T14:13:36Z
dc.date.issued2018
dc.description.abstractAim and Objective: The study was carried out to document the pattern of neurological complications seen in patients with chronic myeloid leukemia who were managed at the University of Ilorin Teaching Hospital, Ilorin and compare with previous reports from other parts of Nigeria and elsewhere. Materials and Methods: A ten year retrospective analysis of all cases of CML managed at the study centre between January 2006 and December 2015 was carried out. Case folders of all patients diagnosed with CML during the study period, and the Malignancy registers of the Haematology department were retrieved and analyzed. Relevant information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. Results: Thirty six (36) patients were diagnosed with CML during the study period. There were 21 (58.3%) males and 15 (41.7%) females, giving a male: female ratio of 1.4:1.The mean age of the patients at diagnosis was 37.5 years (range, 11-75 years). Nine (25%) patients presented with various forms of neurological complications and the mean WBC count in them was 383.2 x 109/L (280.5 601.0 x 109/L). Auditory complications were the commonest neurological deficits found in 6(66.7%) of the 9 patients with neurological manifestations. Conclusion: The neurological complications recorded in this study were similar to those reported in previous studies from Nigeria and other countries. These complications need to be looked for at presentation and adequately characterized as their presence could significantly influence the prognosis of the disease and decisions on management modalities.en_US
dc.identifier.citationBabatunde, A.S., Olawumi, H.O., Durotoye, I.A., Shittu, A.O., Sanni, E.O., & Oyeleke, S.A. (2018). Pattern of neurological complications of chronic myeloid leukaemia in Ilorin, Nigeria: A ten year review. Archives of Clinical Research. 6: 10 -16. https://aauekpoma.edu.ng/index.php?option=com_content&view=categories&id=62&Itemid=232en_US
dc.identifier.urihttp://hdl.handle.net/123456789/4044
dc.language.isoenen_US
dc.publisherFaculty of Clinical Sciences, College of Medicine, Ambrose Alli Universityen_US
dc.subjectPattern, Neurological, Complications, CML, Nigeriaen_US
dc.titlePattern of neurological complications of chronic myeloid leukaemia in Ilorin, Nigeria: A ten year reviewen_US
dc.typeArticleen_US

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