Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in north west Nigeria
No Thumbnail Available
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
Makerere University
Abstract
Abstract
Background: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation
with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares
these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women.
Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and
eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1,
D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method
on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level
of significance was a p-value <0.05.
Results: The mean age of the respondents was 29.9±5.2 years. The median(25th-75th percentile) values of D-dimer, tPA,
and PAI-1 of subjects were 730 (305.000-1560.000ng/ml), 0.11 (0.065-0,300ng/ml) and 3.65 (2.970-4,400ng/ml) respectively
which were significantly higher than the corresponding values in the controls of 520 (24.000-1030.000ng/ml), 0.05
(0.040-0.090ng/ml and 2.650 (2.125-3.400ng/ml) respectively, p<0.05 each.
Conclusion: The abnormal levels of PAI-1,D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty
state in pre-eclampsia thus, measuring their levels can help in the management of the condition.
Description
Keywords
Fibrinolysis, pregnancy, pre-eclampsia
Citation
22. Oladosu-Olayiwola, O., Olawumi, H., Babatunde, A., Ijaiya, M., Durotoye, I., Biliaminu, S., & Ibraheem, R. (2018). Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in north west Nigeria. African Health Sciences, 18(3): 576-583.