Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in north west Nigeria
dc.contributor.author | Oladosu-Olayiwola, O. | |
dc.contributor.author | Olawumi, H. | |
dc.contributor.author | Babatunde, A. | |
dc.contributor.author | Ijaiya, M. | |
dc.contributor.author | Durotoye, I. | |
dc.contributor.author | Biliaminu, S. | |
dc.contributor.author | Ibraheem, R. | |
dc.date.accessioned | 2020-05-23T20:18:11Z | |
dc.date.available | 2020-05-23T20:18:11Z | |
dc.date.issued | 2018 | |
dc.description.abstract | Abstract Background: The hypercoagulability of pregnancy is exaggerated in pre-eclamptic state because of endothelial activation with resultant production of some endothelial derived proteins that are said to be inhibitors of fibrinolysis. This study compares these proteins like tPA, PAI-1 and D-dimers in normal pregnant women and the pre-eclamptic women. Methodology: This was a comparative cross-sectional study. Eighty-five pre-eclamptic women were recruited as subjects and eighty five age, trimester and parity matched normotensive pregnant women as controls. Levels of PT, aPTT, tPA, PAI-1, D-dimer protein were determined in blood samples of subjects and controls. Urinalysis was performed with dipstick method on their urine samples. Data generated was analysed using the IBM®SPSS 20.0 (2011) soft ware packages and the level of significance was a p-value <0.05. Results: The mean age of the respondents was 29.9±5.2 years. The median(25th-75th percentile) values of D-dimer, tPA, and PAI-1 of subjects were 730 (305.000-1560.000ng/ml), 0.11 (0.065-0,300ng/ml) and 3.65 (2.970-4,400ng/ml) respectively which were significantly higher than the corresponding values in the controls of 520 (24.000-1030.000ng/ml), 0.05 (0.040-0.090ng/ml and 2.650 (2.125-3.400ng/ml) respectively, p<0.05 each. Conclusion: The abnormal levels of PAI-1,D-dimer and tPA imply that they contribute to the exaggerated hypercoagulabilty state in pre-eclampsia thus, measuring their levels can help in the management of the condition. | en_US |
dc.identifier.citation | 22. Oladosu-Olayiwola, O., Olawumi, H., Babatunde, A., Ijaiya, M., Durotoye, I., Biliaminu, S., & Ibraheem, R. (2018). Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in north west Nigeria. African Health Sciences, 18(3): 576-583. | en_US |
dc.identifier.uri | http://hdl.handle.net/123456789/4020 | |
dc.language.iso | en | en_US |
dc.publisher | Makerere University | en_US |
dc.subject | Fibrinolysis | en_US |
dc.subject | pregnancy | en_US |
dc.subject | pre-eclampsia | en_US |
dc.title | Fibrinolytic proteins of normal pregnancy and pre-eclamptic patients in north west Nigeria | en_US |
dc.type | Article | en_US |