Characterization of hemopoietic engraftment kinetics and development of secondary cytopenia in AML post Auto-SCT and its correlation with survival outcome
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Date
2009
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
We performed a single center retrospective analysis of
84 autologous hemopoietic stem cell transplants done
for AML to characterize the pattern of hemopoietic
engraftment, post-transplant cytopenia and their impact
on survival outcome. Following autologous transplant
and engraftment, 30 patients (35.7%) had a transient
secondary decline in their plt counts, which was not
associated with graft rejection, relapse or infection. The
median time to onset of thrombocytopenia was 59 days
post transplant, with spontaneous recovery after a median
period of 41 days. A secondary decline in ANC also
occurred in eight patients. Patients with secondary plt
decline had a significantly earlier primary plt engraftment
(median 15 days) and a trend towards earlier neutrophil
engraftment compared with patients who maintained
steady plt counts (median 21 days). There was a trend
towards a lower incidence of secondary plt decline in
patients who received BM stem cells compared with those
who received PBSC. No cause was evident for the
occurrence of a secondary cytopenia, and it did not
adversely affect survival. We conclude that secondary
cytopenia is a common and harmless occurrence after
autologous transplant especially from PBSC graft.
Bone Marrow Transplantation (2009) 44, 175–183;
doi:10.1038/bmt.2009.1; published online 9 February 2009
Keywords: acute myeloid leukemia; autologous hemopoietic
stem cell transplant; engraftment kinetics; secondary
platelet decline; secondary cytopenia
Description
Keywords
acute myeloid leukemia;, autologous hemopoietic stem cell transplant;, secondary cytopenia, secondary platelet decline;, engraftment kinetics;
Citation
10. Babatunde, A.S., Tan, D.C.L., Heng, K.K., Lee, J.J., Loh, Y.S.M., Hwang, W.Y.K., Koh M.B.C., Goh, Y.T, &Linn, Y.C. (2009). Characterization of hemopoietic engraftment kinetics and development of secondary cytopenia in AML post Auto-SCT and its correlation with survival outcome. Bone Marrow Transplantation, 44:175-183.