Characterization of hemopoietic engraftment kinetics and development of secondary cytopenia in AML post Auto-SCT and its correlation with survival outcome

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dc.contributor.authorBabatunde, A.S.
dc.contributor.authorTan, D.C.L
dc.contributor.authorHeng, K.K
dc.contributor.authorLee, J.J
dc.contributor.authorLoh, Y.S.M
dc.contributor.authorGoh, Y.T
dc.contributor.authorLinn, Y.C
dc.date.accessioned2020-05-23T00:12:21Z
dc.date.available2020-05-23T00:12:21Z
dc.date.issued2009
dc.description.abstractWe performed a single center retrospective analysis of 84 autologous hemopoietic stem cell transplants done for AML to characterize the pattern of hemopoietic engraftment, post-transplant cytopenia and their impact on survival outcome. Following autologous transplant and engraftment, 30 patients (35.7%) had a transient secondary decline in their plt counts, which was not associated with graft rejection, relapse or infection. The median time to onset of thrombocytopenia was 59 days post transplant, with spontaneous recovery after a median period of 41 days. A secondary decline in ANC also occurred in eight patients. Patients with secondary plt decline had a significantly earlier primary plt engraftment (median 15 days) and a trend towards earlier neutrophil engraftment compared with patients who maintained steady plt counts (median 21 days). There was a trend towards a lower incidence of secondary plt decline in patients who received BM stem cells compared with those who received PBSC. No cause was evident for the occurrence of a secondary cytopenia, and it did not adversely affect survival. We conclude that secondary cytopenia is a common and harmless occurrence after autologous transplant especially from PBSC graft. Bone Marrow Transplantation (2009) 44, 175–183; doi:10.1038/bmt.2009.1; published online 9 February 2009 Keywords: acute myeloid leukemia; autologous hemopoietic stem cell transplant; engraftment kinetics; secondary platelet decline; secondary cytopeniaen_US
dc.identifier.citation10. Babatunde, A.S., Tan, D.C.L., Heng, K.K., Lee, J.J., Loh, Y.S.M., Hwang, W.Y.K., Koh M.B.C., Goh, Y.T, &Linn, Y.C. (2009). Characterization of hemopoietic engraftment kinetics and development of secondary cytopenia in AML post Auto-SCT and its correlation with survival outcome. Bone Marrow Transplantation, 44:175-183.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/4005
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.subjectacute myeloid leukemia;en_US
dc.subjectautologous hemopoietic stem cell transplant;en_US
dc.subjectsecondary cytopeniaen_US
dc.subjectsecondary platelet decline;en_US
dc.subjectengraftment kinetics;en_US
dc.titleCharacterization of hemopoietic engraftment kinetics and development of secondary cytopenia in AML post Auto-SCT and its correlation with survival outcomeen_US
dc.typeArticleen_US

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