Ameliorative Effect of Methanol Extract of Tiger Nut (cyperus Esculentus) On Oxidative Stress Induced By Lead Poisoning In Red Sokoto Goat
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Date
2019-12
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Publisher
Faculty of Veterinary Medicine, University of Abuja
Abstract
Tiger nut is a small tuberous rhizome with medicinal and antioxidant properties. The present study
was conducted to investigate the ameliorative effect of the methanol extract of tiger nut against the
oxidative stress induced by lead acetate poisoning in Red Sokoto goat (RSG). Twelve adults Red
Sokoto goat (16.50 ± 1.41 to 21.92 ± 0.97 kg) were grouped into four. Group I was administered
with equivalent volume of distilled water. Group II was administered with lead acetate (200 mg/kg)
only. Group III was administered with methanol extract of tiger nut (METN) (150 mg/kg) and lead
acetate (200 mg/kg). Group IV was administered METN (200 mg/kg) only. The serum oxidative
stress changes in the different experimental groups were determined by commercial kits. The
distilled water group showed no toxic response. The lead acetate (200 mg/kg) group showed
decreased activity levels of glutathione, superoxide dismutase (SOD) and catalase (CAT). The cotreatment
groups with lead acetate and METN showed an increase in serum glutathione
peroxidase (GPx) activity, CAT and SOD. Additionally, there was a decreased MDA concentration
in the same group. The group administered with METN only showed slight changes in the activities
of oxidative stress makers. In conclusion, Oxidative stress biomarkers such as glutathione
peroxidases, superoxide dismutase, catalase and malondialdehyde were altered in a manner
indicative of oxidative stress following lead acetate exposure and ameliorated to some extent by
methanolic extract of tiger nut.
Description
Keywords
Tiger nut, Red Sokoto Goat, Oxidative Stress, Lead poisoning
Citation
Adam M. et al, 2019