Ameliorative Effect of Methanol Extract of Tiger Nut (cyperus Esculentus) On Oxidative Stress Induced By Lead Poisoning In Red Sokoto Goat

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dc.contributor.authorAdam, M.
dc.contributor.authorEsievo, K. A. N.
dc.contributor.authorAyo, J. O.
dc.contributor.authorBisalla, M.
dc.contributor.authorAdamu, S.
dc.date.accessioned2020-05-22T11:54:32Z
dc.date.available2020-05-22T11:54:32Z
dc.date.issued2019-12
dc.description.abstractTiger nut is a small tuberous rhizome with medicinal and antioxidant properties. The present study was conducted to investigate the ameliorative effect of the methanol extract of tiger nut against the oxidative stress induced by lead acetate poisoning in Red Sokoto goat (RSG). Twelve adults Red Sokoto goat (16.50 ± 1.41 to 21.92 ± 0.97 kg) were grouped into four. Group I was administered with equivalent volume of distilled water. Group II was administered with lead acetate (200 mg/kg) only. Group III was administered with methanol extract of tiger nut (METN) (150 mg/kg) and lead acetate (200 mg/kg). Group IV was administered METN (200 mg/kg) only. The serum oxidative stress changes in the different experimental groups were determined by commercial kits. The distilled water group showed no toxic response. The lead acetate (200 mg/kg) group showed decreased activity levels of glutathione, superoxide dismutase (SOD) and catalase (CAT). The cotreatment groups with lead acetate and METN showed an increase in serum glutathione peroxidase (GPx) activity, CAT and SOD. Additionally, there was a decreased MDA concentration in the same group. The group administered with METN only showed slight changes in the activities of oxidative stress makers. In conclusion, Oxidative stress biomarkers such as glutathione peroxidases, superoxide dismutase, catalase and malondialdehyde were altered in a manner indicative of oxidative stress following lead acetate exposure and ameliorated to some extent by methanolic extract of tiger nut.en_US
dc.identifier.citationAdam M. et al, 2019en_US
dc.identifier.issn2635-3067
dc.identifier.urihttp://hdl.handle.net/123456789/3933
dc.language.isoenen_US
dc.publisherFaculty of Veterinary Medicine, University of Abujaen_US
dc.relation.ispartofseries2;130 - 136
dc.subjectTiger nuten_US
dc.subjectRed Sokoto Goaten_US
dc.subjectOxidative Stressen_US
dc.subjectLead poisoningen_US
dc.titleAmeliorative Effect of Methanol Extract of Tiger Nut (cyperus Esculentus) On Oxidative Stress Induced By Lead Poisoning In Red Sokoto Goaten_US
dc.typeArticleen_US

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