Modulation of rat serum lipid profile and nephrotic indices following oral exposure to the extracts of chilli pepper
No Thumbnail Available
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
EurAsian Journal of BioSciences Eurasia J Biosci
Abstract
Background: The increasing application of plants for medicinal purposes necessitates safety/toxicity
profiling.
Objective: In the present study, we evaluated the toxicological effects of the ethanolic extracts of the
leaves (CAL), root (CAR) and stem (CAS) of Capsicum annuum in rats.
Methods: Male Wistar rats were randomly assigned groups and given oral administration of the
extracts or distilled water for 28 days.
Results: Data showed that administration of ethanolic extracts of CAL, CAR and CAS did alter the
liver function indices but not in a clear-cut manner to suggest hepatotoxicity. The CAR and CAS
extracts decreased (p<0.05) the rat serum albumin levels compared with the control. In contrast, CAL
extracts raised (p<0.05) the rat serum albumin level relative to the control. The plant extract
administration raised rat serum bilirubin level compared with the control. Further, the extracts caused
reduction (p<0.05) in rat serum TAG levels compared with the control. The CAL, CAR and CAS
extracts did not significantly affect the rat serum creatinine level, but caused significant elevation of
rat serum urea compared with the control.
Conclusion: Taken together, findings do not only support the cardio-protective potential of C.
annuum extracts, but implicate the nephrotoxic tendency of the plant extracts.
Description
Evaluation of medicinal plants and/or herbal remedies for toxicity and safety profiling is imperative to integration of traditional medicines with conventional therapies. Chili pepper (Capsicum annuum L) is a specie wildly cultivated and it is said to be used since ancient times as flavouring, food and for human health (Ballina-Gomez et al. 2013). In the present study, we investigated the toxicity profiling of the ethanolic extracts of C. annuum in rats as well as determined the GC-MS fingerprints of the extracts.
Keywords
herbs, Phytoconstituents, spices, toxicity, medicinal biochemistry
Citation
FA Sulaiman, BO Yusuf, SA Omar, HT Muritala, MJ Adisa, AA Olopade, FI Babajamu , AT Jimba, AL Babatunde, BA Adeniyi, BR Opaleye, RF Maimako , DA Otohinoyi , OK Bello , D Rotimi, TD Olaolu, CO Nwonuma, OO Alejolowo, GE Batiha, OO Osemwegie, OS Adeyemi. (2019). Modulation of rat serum lipid profile and nephrotic indices following oral exposure to the extracts of chilli pepper. EurAsian Journal of BioSciences Eurasia J Biosci 13, 2321-2326. Available online at http://www.ejobios.org/download/modulation-of-rat-serum-lipid-profile-and-nephrotic-indices-following-oral-exposure-to-the-extracts-7409.pdf