Modulation of rat serum lipid profile and nephrotic indices following oral exposure to the extracts of chilli pepper

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dc.contributor.authorSulaiman, F.A
dc.contributor.authorYusuf, B.O
dc.contributor.authorOmar, S.A
dc.contributor.authorMuritala, H.T
dc.contributor.authorAdisa, M.J
dc.contributor.authorOlopade, A.A
dc.contributor.authorBabajamu, F.I
dc.contributor.authorJimba, A.T
dc.contributor.authorBabatunde, A.L
dc.contributor.authorAdeniyi, B.A
dc.contributor.authorOpaleye, B.R
dc.contributor.authorMaimako, R.F
dc.contributor.authorOtohinoyi, D.A
dc.contributor.authorBello, O.K
dc.contributor.authorRotimi, D
dc.contributor.authorOlaolu, T.D
dc.contributor.authorNwonuma, C.O
dc.contributor.authorAlejolowo, O.O
dc.contributor.authorBatiha, G.E
dc.contributor.authorosemwegie, O.O
dc.contributor.authorAdeyemi, O.S
dc.date.accessioned2020-01-30T11:03:03Z
dc.date.available2020-01-30T11:03:03Z
dc.date.issued2019
dc.descriptionEvaluation of medicinal plants and/or herbal remedies for toxicity and safety profiling is imperative to integration of traditional medicines with conventional therapies. Chili pepper (Capsicum annuum L) is a specie wildly cultivated and it is said to be used since ancient times as flavouring, food and for human health (Ballina-Gomez et al. 2013). In the present study, we investigated the toxicity profiling of the ethanolic extracts of C. annuum in rats as well as determined the GC-MS fingerprints of the extracts.en_US
dc.description.abstractBackground: The increasing application of plants for medicinal purposes necessitates safety/toxicity profiling. Objective: In the present study, we evaluated the toxicological effects of the ethanolic extracts of the leaves (CAL), root (CAR) and stem (CAS) of Capsicum annuum in rats. Methods: Male Wistar rats were randomly assigned groups and given oral administration of the extracts or distilled water for 28 days. Results: Data showed that administration of ethanolic extracts of CAL, CAR and CAS did alter the liver function indices but not in a clear-cut manner to suggest hepatotoxicity. The CAR and CAS extracts decreased (p<0.05) the rat serum albumin levels compared with the control. In contrast, CAL extracts raised (p<0.05) the rat serum albumin level relative to the control. The plant extract administration raised rat serum bilirubin level compared with the control. Further, the extracts caused reduction (p<0.05) in rat serum TAG levels compared with the control. The CAL, CAR and CAS extracts did not significantly affect the rat serum creatinine level, but caused significant elevation of rat serum urea compared with the control. Conclusion: Taken together, findings do not only support the cardio-protective potential of C. annuum extracts, but implicate the nephrotoxic tendency of the plant extracts.en_US
dc.description.sponsorshipAuthors acknowledge the laboratory staff of the Department of Biochemistry, University of Ilorin, Nigeria.en_US
dc.identifier.citationFA Sulaiman, BO Yusuf, SA Omar, HT Muritala, MJ Adisa, AA Olopade, FI Babajamu , AT Jimba, AL Babatunde, BA Adeniyi, BR Opaleye, RF Maimako , DA Otohinoyi , OK Bello , D Rotimi, TD Olaolu, CO Nwonuma, OO Alejolowo, GE Batiha, OO Osemwegie, OS Adeyemi. (2019). Modulation of rat serum lipid profile and nephrotic indices following oral exposure to the extracts of chilli pepper. EurAsian Journal of BioSciences Eurasia J Biosci 13, 2321-2326. Available online at http://www.ejobios.org/download/modulation-of-rat-serum-lipid-profile-and-nephrotic-indices-following-oral-exposure-to-the-extracts-7409.pdfen_US
dc.identifier.issn2321-2326
dc.identifier.urihttp://hdl.handle.net/123456789/3601
dc.language.isoen_USen_US
dc.publisherEurAsian Journal of BioSciences Eurasia J Bioscien_US
dc.subjectherbsen_US
dc.subjectPhytoconstituentsen_US
dc.subjectspicesen_US
dc.subjecttoxicityen_US
dc.subjectmedicinal biochemistryen_US
dc.titleModulation of rat serum lipid profile and nephrotic indices following oral exposure to the extracts of chilli pepperen_US
dc.typeArticleen_US

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