Haematological Status of T. brucei-infected Rats Treated with Ibuprofen
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Date
2010
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Publisher
Nigerian Journal of Biochemistry and Molecular Biology
Abstract
Available drugs in the management of African Trypanosomiasis are toxic, regimented and costly, generally non
affordable by the poor and hence the need to continue research work in seeking inexpensive, readily available
and less cumbersome approaches to the management and treatment of the disease. Ibuprofen belongs to a class
of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). It was chosen not only because it chelates iron,
but also because it is cheap, readily affordable and available. In this study, Trypanosoma brucei-infected rats
were treated with ibuprofen at three days before infection (prophylaxis), three days post infection (early stage)
and ten days post infection (late stage). Three sets of controls were set up against the experiment: positive, negative
and normal control. Haematological indices of the serum of each group of rats were obtained for day 6, 12
and 18 . It was observed that the PCV and Hb levels were significantly lower in the late stage-rats compared to
the normal control. Ibuprofen was able to extend the life span of the rats for 2, 4 and 7 days in late, early and
prophylaxis stages respectively. Thus, ibuprofen could be a useful, cheap and readily available drug in the management
of African sleeping sickness for residents of disease endemic areas.
Description
At the end of this research work, we concluded that ibuprofen could be a useful, cheap and readily
available drug in the management of African sleeping sickness for residents of disease endemic
areas. We therefore recommend the use of ibuprofen in the management of the disease, trypanosomiasis which has become a scourge to man and his domestic animals. The drug is readily available and
affordable to the less privileged.
Keywords
Trypanosomiasis, T.brucei brucei, Ibuprofen, Iron chelator
Citation
Sulaiman, F.A., Akanji, M.A. & Ekanem, J.T. (2010): Haematological status of T. brucei brucei infected rats treated with ibuprofen. Nigerian Journal of Biochemistry and Molecular Biology. 25(2):23-27. ISSN: 0189 - 757. Published by Nigerian Journal of Biochemistry and Molecular Biology (NJBMB). Available online at https://www.researchgate.net/profile/Oluyomi_Adeyemi/publication/27790393_Therapeutic_Properties_And_Serum_Iron_In_T_Brucei_Infected_Rats_Treated_With_Amodiaquine_And_Mefloquine/links/02bfe50fd7635a39b4000000.pdf and http://www.njbmb.researchjournals.org; http://www.njbmb.org/Content/Volume%2025%20Number%202%202010.htm