Haematological Status of T. brucei-infected Rats Treated with Ibuprofen

dc.contributor.authorSulaiman, F.A
dc.contributor.authorAkanji, M.A
dc.contributor.authorEkanem, J.T
dc.date.accessioned2020-01-24T12:08:38Z
dc.date.available2020-01-24T12:08:38Z
dc.date.issued2010
dc.descriptionAt the end of this research work, we concluded that ibuprofen could be a useful, cheap and readily available drug in the management of African sleeping sickness for residents of disease endemic areas. We therefore recommend the use of ibuprofen in the management of the disease, trypanosomiasis which has become a scourge to man and his domestic animals. The drug is readily available and affordable to the less privileged.en_US
dc.description.abstractAvailable drugs in the management of African Trypanosomiasis are toxic, regimented and costly, generally non affordable by the poor and hence the need to continue research work in seeking inexpensive, readily available and less cumbersome approaches to the management and treatment of the disease. Ibuprofen belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). It was chosen not only because it chelates iron, but also because it is cheap, readily affordable and available. In this study, Trypanosoma brucei-infected rats were treated with ibuprofen at three days before infection (prophylaxis), three days post infection (early stage) and ten days post infection (late stage). Three sets of controls were set up against the experiment: positive, negative and normal control. Haematological indices of the serum of each group of rats were obtained for day 6, 12 and 18 . It was observed that the PCV and Hb levels were significantly lower in the late stage-rats compared to the normal control. Ibuprofen was able to extend the life span of the rats for 2, 4 and 7 days in late, early and prophylaxis stages respectively. Thus, ibuprofen could be a useful, cheap and readily available drug in the management of African sleeping sickness for residents of disease endemic areas.en_US
dc.identifier.citationSulaiman, F.A., Akanji, M.A. & Ekanem, J.T. (2010): Haematological status of T. brucei brucei infected rats treated with ibuprofen. Nigerian Journal of Biochemistry and Molecular Biology. 25(2):23-27. ISSN: 0189 - 757. Published by Nigerian Journal of Biochemistry and Molecular Biology (NJBMB). Available online at https://www.researchgate.net/profile/Oluyomi_Adeyemi/publication/27790393_Therapeutic_Properties_And_Serum_Iron_In_T_Brucei_Infected_Rats_Treated_With_Amodiaquine_And_Mefloquine/links/02bfe50fd7635a39b4000000.pdf and http://www.njbmb.researchjournals.org; http://www.njbmb.org/Content/Volume%2025%20Number%202%202010.htmen_US
dc.identifier.issn0189-4757
dc.identifier.urihttp://hdl.handle.net/123456789/3560
dc.language.isoen_USen_US
dc.publisherNigerian Journal of Biochemistry and Molecular Biologyen_US
dc.subjectTrypanosomiasisen_US
dc.subjectT.brucei bruceien_US
dc.subjectIbuprofenen_US
dc.subjectIron chelatoren_US
dc.titleHaematological Status of T. brucei-infected Rats Treated with Ibuprofenen_US
dc.typeArticleen_US

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