Mixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studies
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Faculty of Physical Sciences, University of Ilorin
Abstract
Some transition metal complexes of mixed artemether, ascorbic acid and
lumefantrine have been synthesized and characterized using UV/Vis, FTIR, Atomic
Absorption Spectroscopy (AAS) and Gas chromatography-Mass Spectroscopy (GCMS). The results revealed that the artemether and ascorbic acid are chelating ligands
and coordinates through the oxygen of the carbonyl groups while lumefantrine
coordinates through the hydroxyl group in a monodentate fashion. The metal
complexes were investigated for biological activity using five bacterial species -
Staphylococcus aureus, Escherichia coli, Bacillus aureus and Pseudomonas
aeruginosa. It was observed that the synthesized complexes were more effective
towards the five bacteria species than the free drugs.
Description
Keywords
Artemether, Lumefantrine, Ascorbic acid, Metal complexes, Biological activity