Mixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studies

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dc.contributor.authorBabamale, Halimah Funmilayo
dc.contributor.authorObaleye, Joshua A
dc.contributor.authorLawal, Amudalat
dc.contributor.authorRajee, Abdullahi O
dc.contributor.authorBamigboye, Mercy O
dc.contributor.authorLawal, Misitura
dc.contributor.authorSa'ad, H. O
dc.date.accessioned2023-08-22T14:19:50Z
dc.date.available2023-08-22T14:19:50Z
dc.date.issued2019
dc.description.abstractSome transition metal complexes of mixed artemether, ascorbic acid and lumefantrine have been synthesized and characterized using UV/Vis, FTIR, Atomic Absorption Spectroscopy (AAS) and Gas chromatography-Mass Spectroscopy (GCMS). The results revealed that the artemether and ascorbic acid are chelating ligands and coordinates through the oxygen of the carbonyl groups while lumefantrine coordinates through the hydroxyl group in a monodentate fashion. The metal complexes were investigated for biological activity using five bacterial species - Staphylococcus aureus, Escherichia coli, Bacillus aureus and Pseudomonas aeruginosa. It was observed that the synthesized complexes were more effective towards the five bacteria species than the free drugs.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/11674
dc.language.isoenen_US
dc.publisherFaculty of Physical Sciences, University of Ilorinen_US
dc.subjectArtemetheren_US
dc.subjectLumefantrineen_US
dc.subjectAscorbic aciden_US
dc.subjectMetal complexesen_US
dc.subjectBiological activityen_US
dc.titleMixed metal complexes of Artemether, Lumefantrine and Ascorbic acid: Synthesis, characterization and biological activity studiesen_US
dc.typeArticleen_US

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