Phytochemical and Anticonvulsant Activity of the Ethanol Root Bark Extract of Mimosa pigra L. (Fabaceae) in Laboratory Animals
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Date
2024-06-22
Journal Title
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Publisher
Nig. J. Pharm. Res
Abstract
Background and objectives: Various parts of Mimosa pigra (MPG) are used in traditional medicines to treat
convulsive disorders. The objective of this study was to investigate the anticonvulsant properties of Mimosa pigra
ethanol root extract (EREM).
Methods: The acute toxicity of the extract was investigated using OECD 423 protocol of 2002. The anticonvulsant
properties of EREM at 200,400 and 800 mg/kg were evaluated using Maximal Electroshock Test (MEST) in chicks;
strychnine (SCN-) and pentylenetetrazole (PTZ)-induced seizures in mice.
Results: The extract at 400 and 800 mg/kg significantly (p<0.05) prolonged the mean onset of clonic and tonic
convulsions in mouse model of SCN-induced seizure. In PTZ-induced seizure, the extract at 400 mg/kg significantly
(p<0.05) increased the mean onset of clonic seizure, while at 800 mg/kg, there was significant (p<0.05) prolongation
in the mean onset of clonic and tonic seizure compared to control. The extract did not protect the chick against MEST
but significantly (p < 0.05) reduced the mean recovery time at the of 200, 400 and 800 mg/kg. The extract offered 60
and 100% protection at 400 and 800 mg/kg respectively in SCN-induced seizure. Similarly, EREM offered 20 and
40% protection at 400 and 800 mg/kg respectively in PTZ-induced seizure. Diazepam (10 mg/kg), a reference drug
significantly (p<0.05) prolonged the onset of clonic-tonic seizure and protected against SCN-, and PTZ-induced
convulsion in mice.
Conclusion: These findings indicated that EREM may possess anticonvulsant activity in SCN-, and PTZ-induced
seizure in mice. Thus, lend scientific credence to the anticonvulsant claim of EREM in ethnomedicine.
Description
Keywords
Mimosa pigra, Ethnomedicinal claim, Maximal Electroshock Test, Pentylenetetrazole, Strychnine