Protective Potential of Thymoquinone on Cyclophosphamide-Induced Hepatotoxicity in Rat
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Date
2022
Journal Title
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Publisher
National Association of Specialist Medical Doctors in Academics in Nigeria
Abstract
Background: Cyclophosphamide (CYC) has been known as an
anticancer drug with several side effects on various organs such as the liver. In this study, the hepatoprotective properties of thymoquinone (TQ) were tested to decrease the damaging effects of Cyclophosphamide on the liver.
Objective: To study and observe the possible ameliorative effect of thymoquinone on cyclophosphamide-induced hepatic toxicity in Wistar rats. Methods: Thirty Wistar male Adolescent (8 – 9 weeks old) rats weighing 70g – 150g were divided into Six groups; 5 rats per group (n=5) and treated orally for 21 consecutive days. Group A served as the control, and the rats in this group received normal saline. Group B was treated with 20mg/kg of cyclophosphamide. Group C was treated with 5mg/kg of Thymoquinone. Group D was treated with 10mg/kg of Thymoquinone. Group E was treated with 20mg/kg of cyclophosphamide and 5m/kg of Thymoquinone while Group F animals were treated with 20mg/kg of Cyclophosphamide and 10mg/kg of Thymoquinone.
Results: The Cyclophosphamide treated group showed significant decreases in the body and liver weight, distorted hepatic cytoarchitecture, and reduction in hepatic function whereas co-treatment with TQ, showed protective effects on Cyclophosphamide-induced hepatotoxicity damage.
Conclusion: These results suggest that the administration of
Thymoquinone may have a protective potential on Cyclophosphamide induced hepatotoxicity.
Description
Keywords
Cyclophosphamide, Thymoquinone, Hepatotoxicity
Citation
Adana, M. Y., Opabunmi, E. T., Sunmonu, O. E., Bello, A. A., Onigbolabi, O. G., Imam A., Ajao, M. S. (2022). Protective Potential of Thymoquinone on Cyclophosphamide-induced Hepatotoxicity in Rats. Nigerian Journal of Basic and Applied Medical Sciences, 1(1), 44-47. Published by the National Association of Specialist Medical Doctors in Academics in Nigeria. Available online at https://njbams.asmeda.org.ng/view_volume.php?volume=2&issue=1&year=2022