Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease model
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Date
2024
Journal Title
Journal ISSN
Volume Title
Publisher
Korean Association of Anatomists
Abstract
: Parkinson’s disease (PD) affects about 8.5 million individuals worldwide. Oxidative and inflammatory cascades are
implicated in the neurological sequels, that are mostly unresolved in PD treatments. However, proper nutrition offers one of the most
effective and least costly ways to decrease the burden of many diseases and their associated risk factors. Moreover, prevention may
be the best response to the progressive nature of PD, thus, the therapeutic novelty of honey and levodopa may be prospective. This
study aimed to investigate the neuroprotective role of honey and levodopa against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)-induced oxidative stress. Fifty-four adult male Swiss mice were divided into control and PD model groups of 27 mice. Each
third of the control mice either received phosphate buffered saline, honey, or levodopa for 21 days. However, each third of the PD
models was either pretreated with honey and levodopa or not pretreated. Behavioral studies and euthanasia were conducted 2 and
8 days after MPTP administration respectively. The result showed that there were significantly (P<0.05) higher motor activities in
the PD models pretreated with the honey as well as levodopa. furthermore, the pretreatments protected the midbrain against the
chromatolysis and astrogliosis induced by MPTP. The expression of antioxidant markers (glutathione [GSH] and nuclear factor
erythroid 2-related factor 2 [Nrf2]) was also significantly upregulated in the pretreated PD models. It is thus concluded that honey
and levodopa comparably protected the substantia nigra pars compacta neurons against oxidative stress by modulating the Nrf2
signaling molecule thereby increasing GSH level to prevent MPTP-induced oxidative stress.
Description
Keywords
Honey, Nrf2, Levodopa, 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine, Parkinson disease
Citation
Sulaimon, F. A., Ibiyeye, R. Y., Imam, A., Oyewole, A. L., Imam, A. L., Shehu, M., Biliaminu, S. A., Kadir, R. E., Omotoso, G. O., & Ajao, M. S. (2024). Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease model. Anatomy & Cell Biology, 57 (3), 431-445