Exogenous melatonin restored the cytoarchitectural integrity and biochemical activities of the cerebrum in sodium fluoride-induced toxicity.
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Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Spanish Society of Anatomy and the Mexican Society of Anatomy
Abstract
The cerebrum is responsible for motor, sensory
and autonomic activities of the human body, and it
is believed that fluoride exposure to the biological
system can impede these functions. Therefore,
it is imperative to introduce melatonin to limit
the extent of fluoride toxicity on the cerebrum
and understand the mechanism involved in the
aforementioned process. Thirty-two rats were
randomly selected into 4 groups (n=8, per group).
Groups I-IV received oral administration of
0.2ml of normal saline (NS), 500ppm of sodium
fluoride (NaF), concurrent administration of
sodium fluoride and melatonin (NaF+MLT), and
sodium fluoride before melatonin (NaF-MLT)
for fourteen days respectively. At the end of
these treatments, the rats were euthanized and
cerebral tissues were excised for histological,
histochemical and biochemical analyses. Sodium
fluoride distorted the shapes and size of the cells
and caused constriction of the blood vessels, as
well as presence of vacuolations in the cells of the pyramidal layer of the cerebral cortex. However,
melatonin was able to restore the cytoarchitecture
of cells of the pyramidal layer of the cerebral
cortex when administered concurrently and
after the administration of sodium fluoride (NaF)
respectively. Also, melatonin regulated the activities
of Superoxide dismutase, Malondialdehyde and
Glutathione peroxidase in the cerebrum. Sodium
fluoride causes neurodegeneration in the cerebral
cortex, and exogenous melatonin can ameliorate
the injury caused by sodium fluoride on the
cerebral cortex.
Description
Keywords
Cerebrum – Neurodegeneration – Cytoarchitecture – Melatonin – Sodium fluoride
Citation
Ibrahim-Abdulkareem, R. A., Okesina, A. A., Sulaimon, F. A., Imam, A. Yawson, E., Oluyomi, O.O., & Ajao M.S (2021). Exogenous melatonin restored the cytoarchitectural integrity and biochemical activities of the cerebrum in sodium fluoride-induced toxicity. European Journal of Anatomy. 25 (5), 533-540