Enhanced hepatic glycogen synthesis and suppressed adenosine deaminase activity by lithium attenuates hepatic triglyceride accumulation in nicotine exposed ra
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Date
2018-10-12
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Publisher
Elsevier
Abstract
Reduced liver glycogen synthesis might signify increased glucose flux towards fat synthesis and triggers hepatic
triglyceride accumulation and dysmetabolism. Adenosine deaminase (ADA) reduces adenosine content which
increases glycogenolysis. In the present study, we evaluate the effect of modulating glycogen synthesis and ADA
by lithium chloride (LiCl) on nicotine-induced dysmetabolism. Twenty four male Wistar rats (n = 6/group) were
allotted into four groups namely; vehicle-treated (po), nicotine-treated (1.0 mg/kg; po), LiCl-treated (5.0 mg/kg;
po) and nicotine + LiCl-treated groups. The treatments lasted for 8 weeks. Nicotine exposure resulted in reduced
body weight gain, liver weight, visceral adiposity, glycogen content and synthase. Along with increased insulin
resistance (IR), fasting plasma glucose, lactate, plasma and hepatic ADA, XO, UA, and triglyceride (TG), total
cholesterol (TC), free fatty acid, lipid peroxidation and liver injury markers. However, plasma and hepatic
glucose-6-phosphate dehydrogenase-dependent antioxidant defenses were not affected by nicotine exposure.
Concurrent treatment with LiCl normalizes all alterations with exception of hepatic TC. This result shows that
enhancement of hepatic glycogen synthesis and suppression of ADA/XO/uric acid pathway by lithium can
salvage the liver from nicotine-induced TG accumulation.
Description
Keywords
Lithium, Glycogen synthesis inhibition, Adenosine deaminase, Uric acid, NAFLD
Citation
Dangana, E.O., Michael, O.S., Omolekulo, T.E., Areola, E.D., & Olatunji, L.A., (2019). Enhanced hepatic glycogen synthesis and suppressed adenosine deaminase activity by lithium attenuates hepatic triglyceride accumulation in nicotine-exposed rats. Biomedicine and Pharmacotherapy, 109, 1417-1427, Published by Elsevier. Available online at: Biomedicine & Pharmacotherapy | Vol 109, Pages 1-2572 (January 2019) | ScienceDirect.com by Elsevier