Sub-Acute Toxicological Evaluation of An Artemisia-Based Moringa Supplement (AMS)
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Date
2025
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Published by the College of Health Sciences, University of Ilorin
Abstract
Background: In developing nations, several natural medicine practitioners explore the use of plant-based
supplements and other forms of phytotherapies to combat viral infection via immune-boosting mechanisms. One
such supplement is a locally compounded and consumed Moringa supplement containing and
named, artemisia-based Moringa supplement (AMS). The aim of this study was to evaluate the effect of a subacute
(30 days) administration of AMS on the toxicological indices in albino Wistar rats of both sexes.
artemisia annua
Results: There were no adverse hematological effects because of AMS treatment. Serum electrolytes levels were
not affected across the doses of AMS administered for 30 days. Creatinine levels were not significantly altered,
however a significant (p = 0.037) reduction in urea level was observed in the highest dose of 500 mg/kg. Liver
function assays showed no significant alterations in the liver function enzymes, although, a significant decrease
in the liver malonaldehyde (MDA, product of lipid peroxidation) level was observed. There was no adverse effect
on kidney function parameters and serum lipid profile.
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Keywords
Artemisia annua, Nutraceuticals, Hepatotoxicity, Serum biochemistry, Hematology