Evaluation of in vivo antimalarial activity of the ethanolic leaf extract of Chromolaena odorata and Cymbopogon citratus in mice
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Date
2012
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Publisher
Biotechnology Society of Nigeria
Abstract
Malaria has remained a leading cause of morbidity and mortality in tropical
countries of the world due to the resistance posed by malaria parasites to most
commonly affordable anti-malarials. The anti plasmodial activities of the ethanolic leaf
extracts of Chromolaena odorata and Cymbopogon citratus on chloroquine sensitive
Plasmodium berghei berghei in mice was evaluated. C. odorata and C. citratus exhibited
significant (p< 0.05) blood schizontocidal activity in a four- day early infection test and in
established infection with a considerable mean survival time comparable to that of the
standard drug chloroquine ( 5mg/ kg/ day). The efficacy of both treatments is further
indicated in the consistent increase in weight and slight increase in the PCV levels of the
treated groups as against those of the untreated groups. The extracts from both plants
showed significant (p<0.05) anti-plasmodial activity and could serve as possible
candidates for the development of new effective drugs for the treatment of malaria.
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Keywords
anti malarial activity, ethanolic leaf extract, Chromolaena odorata, Cymbopogon citratus
Citation
Evaluation, in vivo, ethanolic, Chromolaena odorata, Cymbopogon citratus