Synthesis, characterization, and antimicrobial studies of 3,3-thiodipropionic acid sulfathiazole, sulfamethoxazole, and salicyaldehyde schiff-base metal complexes.
No Thumbnail Available
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Published by University of Ilorin
Abstract
Schiff- bases, as obtained from sulfa drugs, act as ligands capable of effectively coordinating with metal ions. Complexes of mixed sulphathiazole
and 3,3-thiodipropionic acid ligand, and alkaline earth metal complexes of sulfamethoxazole [4-amino-N-(5-methyl-3-isoxazolyl) benzenesulfonamide]
and salicylaldehyde Schiff-base were synthesized by refluxing technique. The metal complexes obtained were characterized by elemental analysis,
spectroscopic techniques (Fourier-transform infrared spectroscopy), and powder X-ray diffraction techniques. The Schiff-base ligand was observed to
bind as a bidentate coordinating via the with N- and O- groups. Fourier transform infrared study of the Schiff-base showed a strong band at 3379cm-1
due to phenolic ʋ(O-H) which is seen to shift to 3471 and 3454 cm-1 in the Ca(II) and Mg(II) complexes respectively, while the ʋ(M-O) and ʋ(M-N) were
seen at 565 and 450 cm-1 respectively in the [Ca(SMX-L)] complex, and at 560 and 460 cm-1 respectively in the [Mg(SMX-L)] complex. Antimicrobial
behaviour of the mixed sulphathiazole and 3,3-thiodipropionic acid metal complexes showed activity against the Staphylococcus aureus (S. aureus),
Klebsiella pneumoniae (Klebsiella spp) Pseudomonas (Pseudo), Escherichia coli (E. coli)Microbes.
Description
Centrepoint Journal (Science Edition), Volume 27, pages 65-79.
Keywords
Schiff base, metal complexes, antimicrobial, alkaline earth metals
Citation
Adimula, V. O., Tella, A. C., Leslie, F. F., Olusegun, K. F., Obafemi, A. D., Adeniyi, E., & Shamle, N. J. (2021). Synthesis, characterization, and antimicrobial studies of 3,3-thiodipropionic acid sulfathiazole, sulfamethoxazole, and salicyaldehyde schiff-base metal complexes. Centrepoint Journal (Science Edition), 27, 65-79