Effect of Dialium guineense Fruit Pulp Meal-based Diet on Haematological parameters, Lipid profile and Organ/body weight ratio of Rats.
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Date
2018
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Faculty of Physical Sciences and Faculty of Life Sciences, University of Ilorin, Ilorin, Nigeria.
Abstract
Haematological, lipid profile and organ/body weight ratio are some of the biochemical parameters used in
assessing the toxicity of a food/drug. The study aimed at determining these parameters in albino rats fed the
fruit pulp of Dialium guineense at 5% - 40 % inclusion levels. 36 rats of both sexes were grouped into 6 (A –
F). A served as the control while B – F where maintained on Dialium guineense fruit pulp meal-based diet at
5% - 40% supplementation respectively for five weeks. Haematological and lipid Profiles were determined
using standard methods while Organ/body weight ratio was expressed in percentage. The study revealed no
alteration in almost all the haematological parameters of the test groups when compared with the control
except for lymphocytes in which a significant increase (p < 0.05) (50.72 ± 1.73%) was observed at 40%
supplementation while for neutrophils, significant increase and decrease (p < 0.05) was observed in the group
fed on 30%; 40% diet (increase)(47.68 ± 2.13%, 48.11 ± 2.20%) and 5% diet (decrease) (41.68 ± 0.99%)
respectively. For the lipid profile, a significant increase was observed at all inclusion levels in the total
cholesterol and high density lipoprotein concentration while there was a significant decrease (p < 0.05) in the
low density lipoprotein concentration, triglyceride and atherogenic index at all inclusion levels of the fruit
pulp. For the Organ body weight ratio, no significant difference (p > 0.05) was observed in all the groups. The
results suggest that the diet might not exhibit structural toxicity on selected organs but portray indications of
minute functional toxicity which are still within the tolerable range.
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Keywords
Haematological parameters, Dialium guineense, Lipid profile, Atherogenic index.