Hepatoprotective Effect of Tryptophan in Carbontetrachloride-Induced Hepatotoxicity in Male Wistar Rats.
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Date
2021
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Society of Basic and Applied Physiology
Abstract
In the present study, tryptophan was evaluated for its hepatoprotective effects against
carbontetrachloride-induced hepatocellular injury in rats. Hepatotoxicity was induced in male SpragueDawley rats by intraperitoneal injection of CCl4 (4ml/kg) in olive oil (1:1). Tryptophan at doses of 100mg/kg
and 200mg/kg was administered orally for 28 days. The hepatoprotective effect of tryptophan was evaluated
by the assay of biochemical parameters viz.: alanine aminotransaminase (ALT), aspartate aminotransaminase
(AST), alkaline phosphatase (ALP), total protein, albumin and lipid peroxidation. Tryptophan produced a
dose-dependent significant increase (p<0.001) in serum ALP (41% & 60%), a dose-dependent decrease
(p<0.001) in serum Malondialdehyde (61% & 65%), and a significant increase (p<0.001) in levels of serum
protein and serum albumin, in CCl4induced hepatotoxic rats, following administration of 100 mg/kg bwand
200 mg/kg bw, respectively. The toxic effect of CCl4 in tryptophan treated groups was controlled significantly
by restoration of the levels of enzymes, total protein and albumin as compared to the CCl4 treated groups.
The results suggest that tryptophan is able to significantly alleviate the hepatotoxicity induced by CCl4 and
may be attributed to the antioxidant property of tryptophan.
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Carbontetrachloride, Hepatotoxicity, Lipid peroxidation, Tryptophan