Improvement of Oral Glucose Tolerance and Total Lipid Profile of Diabetic Rats Treated with Ficus exasperata Leaf-Based Diet
No Thumbnail Available
Date
2019-06
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Faculty of Physical and Life Sciences, Covenant University, Nigeria.
Abstract
The aim of this study was to investigate the effect of Ficus exasperata
leaf-based diet (FELD) on oral glucose tolerance and total lipid profile of type 2
diabetic rats. Forty-eight wistar rats were randomly selected into 8 groups of 6
animals each. All experimental animals apart from the positive control group were
administered with 10 % fructose solution ad libitum for 2 weeks, while those in the
negative control group received distilled water. The remaining groups were
diabetic rats treated with 10, 20, 30, 40 and 50 % FELD for 16 days. Oral glucose
tolerance test (OGTT), cholesterol, triglycerides, high and low density lipoproteins
(HDL and LDL) were assayed for. Result of OGTT before commencement of
treatment showed significant increase (p < 0.05) in the blood glucose
concentration after 30 mins of oral glucose load which was not restored back to the
basal level after 2 hours. OGTT result by the 13th day of treatment showed
significant decrease (p < 0.05) in glucose concentration of FELD-treated diabetic
rats 2 hours after glucose load. There was a significant decrease (p < 0.05) in the
concentration of cholesterol, triglycerides, LDL and a significant increase (p < 0.05)
in HDL concentration of FELD-treated diabetic rats. In conclusion, incorporation
of 30, 40 and 50 % F. exasperata leaf into diet and consumed for 16 days
improved glucose tolerance and total lipid profile of diabetic rats.
Description
Keywords
Oral glucose tolerance, Ficus exasperata leaf-based diet, Total lipid profile, Diabetes mellitus, streptozotocin