Browsing by Author "Zubair, M. F."

Now showing 1 - 4 of 4
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    Chemical constituents and antiproliferative properties of Turraea vogelli Hook. f. ex. Benth leaves.
    (University of Ilorin, 2015) Hamid, A. A.; Negi, A. S.; Zubair, M. F.; Oguntoye, S. O.; Aiyelaagbe, O. O
    Ethyl acetate and methanol extracts of Turraea vogelli leaves exhibited cytotoxic activity on leukaemia carcinoma K562 with IC50 values 85.00 and 85.22 μg/mL respectively. Isolation of the extracts afforded Tetradec-7-enoic acid (1), pentadec-1-ene (2), ethyl tridec-7-enoate (3), β-sitosterol (4) and stigmasterol (5). The structures of these compounds were characterised by IR, ID and 2D NMR and Mass spectroscopy, and supported with literature data. Compounds 1 and 4 exhibited antiproliferative activity against K562 tumor cell lines with IC50 of 57.27 and 27.56 μg/mL respectively. All isolated compounds exhibited low cytotoxicity against WRL and MCF-7 tumor cell lines.
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    International Journal of Chemical Sciences
    (Nasarawa State University, Keffi, 2015-06-01) Ameen, O. M.; Olatunji, G. A.; Usman, L. A.; Adebayo, M. A.; Zubair, M. F.; Opabola, T. O.; Agboola, D. O.
    Dracaena manni Baker (Dracaenacea) is a plant used in trado – medicine for the treatment of various ailments, however literature is scarce about the efficacy of this medicinal plant. Thus the present study investigates this plant to corroborate the claims in trado – medicine and document our findings. The phytochemicals were extracted from the stem of Dracaena manni with ethyl acetate and then methanol. The screening of the extracts was carried out by brine shrimp lethality test (BST), antimicrobial and antifungal tests using microbes. The phytochemical screening revealed the presence of tannins, saponins, alkaloids and anthraquinones in the methanolic extract while the ethyl acetate extract contain steroids, anthraquinones and terpenoids. The antimicrobial and antifungal analyses indicate ethyl acetate extract sensitivity towards Escherichia coli and Candida albicans while methanolic extract was sensitive towards Staphylococcus aureus and Candida albicans. The extracts were not active against the brine shrimp larvae. This study indicates that D. mannii have potential antimicrobial and antifungal activity but there are slight differences in the activities of the extracts based on the solvents that was used for extraction. The results of our findings have indicated the biological activities of the plant extracts and their usability in the preparation of new drugs. However, further study is required to identify the active constituents responsible for these antibacterial and antifungal activities.
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    Nigerian Journal of Biochemistry and Molecular Biology
    (Nigerian Society of Biochemistry and Molecular Biology, 2014-10-01) Zubair, M. F.; Anibijuwon, I. I.; Ameen, O. M.; Abdulrahim, H. A.
    Physalis angulata is a specie of the Solanaceae family, in which edible fruit is used in several countries of tropical and subtropical regions of the world as medicinal and fruit-tree. In this study, the secondary metabolite screening of the crude extracts consisting of (ethanol, ethylacetate, chloroform and n-hexane) of the whole plant and antibacterial activity was investigated against some clinical isolates. The screening of the secondary metabolites revealed some active components such as alkaloids, tannins, terpenoids, phenolics and flavonoids. The antimicrobial screening of the ethanolic extract of the plant at concentrations of 25, 50, 100 and 125 mg/ml revealed various zones of inhibition from 8.2 to 17.2 mm for the different organisms. In conclusion, the extract of Physalis angulata exhibited antibacterial activity made possible by the presence of the secondary metabolite constituents and therefore could be used as antibiotic against the bacteria strains investigated in this study.
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    Structural And Phytochemical Characterization of Bioactive Components of the Endophytic Fungi (Trichoderma harzianum) Extracts
    (University of Port Harcourt, 2022) Ameen, Mubarak O.; Garuba, Taofeeq; Zubair, M. F.; Baker, M. T.; Arowolo, Zainab B.
    This research aims to investigate the antioxidant activity of the crude extract of endophytic fungi (T. harzianum) and to test for the presence of phytochemicals. Fungi isolated from the leaf and stem of endemic medicinal plant were extracted with ethyl acetate. The fungi extract was then investigated for its phytochemicals, antioxidants and active compounds through LC-MS. Some of the phytochemicals present in abundance include saponins, alkaloids, flavonoids, phenols, and steroids, with tanins and cardiac glycosides also present in reasonable amounts. Those compounds identified by LC-MS with antioxidant properties include inosine diphosphate, vigabatrin, isoamylnitrite, proline, trihexyphenidyl-N-oxide, N-methyl gabapentin, penbutolol, dextromoramide M2, solanidine, aceclidine, desethyleneciproflaxin, sapropterin and kinetin.