Browsing by Author "Tella, A.C."
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Item Equilibrium sorption of Pb(II) and nitrate ions from aqueous solution using chemically modified rice husk(Faculty of Science, 2011-09-03) Adediran, G.O.,; Owalude, S.O.,; Tella, A.C.; Olaremu, A.GThe ability of converting a waste product, rice husk, into an economically cheap adsorbents have been investigated for Pb(II) and NO3- removal from aqueous solution through adsorption. The Batch experiments show that the maximum sorption was obtained at the pH between 4 and 5 and at a temperature of 35°C for both ions. Time dependent experiments for the nitrate ions showed that the binding to the husk was rapid and occurred within 50 minutes. The adsorption data followed both the Langmuir and the Freundlich equations but fitted best into the Freundlich model. The adsorption data were analyzed using the pseudo-first-order and pseudo-second-order kinetic equations and the results showed that the adsorption process followed pseudo-second-order kinetics. The sorption data were also correlated with Dubinin-Radushkevich adsorption model and the results showed that the adsorption process is physical.Item An Evaluation of the Impact of Zinc and Copper Metal-Organic Frameworks (MOFs) on the Drug Release Profiles of Piroxicam(Journal of Pharmaceutical Research, Development and Practice, 2020-05) Kola-Mustapha, A.T.; Ayuba, A.A.; Amali, M.O.; Atunwa, S.A.; Ishola, F.; Tella, A.C.Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) poorly soluble in an aqueous medium with a slow and gradual dissolution in biological fluids resulting in sub-optimal efficacy in patients. In recent times, Metal-Organic Frameworks (MOFs), a new class of highly tenable hybrid porous materials with unique properties have been explored for usage as drug carriers and other biomedical applications. This study is aimed at studying the solubility, in vitro release profile and kinetics of piroxicam loaded Zinc and Copper Metal-Organic Frameworks. Piroxicam was loaded on Zinc and Copper MOFs and tested for its solubility, dissolution and drug release profile. The mechanisms of the release pattern of the drug from Zinc and Copper MOFs were analysed using kinetic models. At the end of the study, Piroxicam-loaded Zn MOFs had solubility of 161.34 ± 0.63 μg/mL, while that of Cu MOFs and pure piroxicam had solubility of 154.31 ± 1.27 μg/mL and 134.86 ± 0.48 μg/mL respectively. Within a period of 24 hours, Piroxicam had the highest release from Zn MOFs; with a drug release in the range of 43.70 to 99.10%. Piroxicam was released from the loaded Cu MOFs in the range of 41.20 to 78.3% while the release of pure Piroxicam was in the range of 37.50 to 49.0%. Mechanism of piroxicam release was by Fickian diffusion. Piroxicam was successfully loaded on Zinc and Copper MOFs. Zn MOFs demonstrated a better solubility and dissolution profile as compared to Cu MOFs. These study shows the drug delivery potentials of the Zinc and Copper MOFs in improving the solubility and drug release of piroxicam. ___________________________________________________________________________ KEYWORDS: piroxicam, solubility, zinc, copper, MOFs, drug release.Item A new heterobimetallic ruthenium(II) complex: synthesis, spectral studies and catalytic activity potential in the transfer hydrogenation of ketones(Chemical Society of Nigeria, 2019-06-07) Owalude, S. O.; Tella, A.C.; Eke, U. B.; Odebunmi, E.O.A new heterobimetallic ruthenium(II) complex with general formula [Ru(NCCH3)2(P(OMe)2Ph)2- (dppf)][BF4]2. {NCCH3 = acetonitrile P(OMe)2Ph = dimethylphenylphosphonite, dppf = 1,1’-bis-{diphenylphosphino}ferrocene} was synthesized from a one pot reaction of [Ru(COD)-(NCCH3)4][BF4]2, dimethylphenylphosphonite and 1,1’-bis{diphenylphosphino}ferroc-ene in dichloromethane under continuous stirring. The complex was characterized by NMR (31P{1H}, 1H and 13C), vibrational spectroscopy (FTIR) and elemental analysis. Catalytic performance of the complex in the transfer hydrogenation of cyclohexanone was investigated. An 80% conversion was achieved at a substrate to catalyst ratio of 1250 with 98% selectivity.Item One pot synthesis of group 6 homo-bimetallic carbonyl complexes incorporating a Schiff base and bidentate phosphine ligands(Federal University Wukari, Nigeria, 2016-09-04) Owalude, S. O.; Tella, A.C.; Ohara, M.S.; Eke, U.B.A simple route to the synthesis of two homo-bimetallic molybdenum carbonyl complexes [Mo2(CO)6(HL)2(dppm] (1) and [Mo2(CO)4(HL)2(dppb)] (2) (HL = (E)-2-((2- hydroxybenzylidene)amino)phenol; dppm = bis(diphenylphosphino)methane, dppb = 1,4- bis(diphenylphosphino)butane) have been developed. The two compounds were obtained pure by thermal decarbonylation of Mo(CO)6 using a Schiff base ligand previously prepared by condensation reaction of salicylaldehyde and 2-aminophenol, in the presence of either dppm or dppb. Compounds 1 and 2 were characterized using elemental analysis, IR and NMR (1H, 13C and 31P) spectroscopy. Elemental analysis and spectroscopic data revealed bimetallic complexes with three and two carbonyl remaining in the structure of complex 1 and 2 respectively with diphosphines acting as bridge between the two metals.Item Synthesis and characterization of amino and cyano-functionalized zinc-terephthalate metal–organic frameworks for loading of piroxicam drug.(Chemical Papers,, 2020) Tella, A.C.; Eliagwu, S.E.; Amali, M.; Kola-Mustapha, A.T; Olatunji, S.J.; Ishola, F.; Adimula, V.O.; Oluwafemi, O.SItem Synthesis of new ruthenium(II) complexes containing isocyanide and labile nitrile ligands(Ahmadu Bello University, Zaria, Nigeria, 2017-10-30) Owalude, S. O.; Tella, A.C.; Eke, U. B.; Odebunmi, E.O.A new ruthenium(II) complex containing both acetonitrile and propionitrile moieties as coordinating ligands has been prepared. The treatment of the polymer [{RuCl2(COD)}x], (COD = cycloocta-1,5-diene) (1) with a mixture of acetonitrile and propionitrile under reflux produced a new precursor [RuCl2(COD)(NCCH3)(CH3CH2CN)] (2). Also the compound [RuCl2L4] (3) (L = 2,6-dimethylphenylisocyanide) was prepared through a ligand exchange of a derivative of 1, [RuCl2(COD)(NCCH3)2] (4), with 2,6-dimethylphenylisocyanide. The two compounds were characterized by elemental analyses, IR and NMR (1H and 13C) measurements. The ruthenium in both compounds has distorted octahedral coordination geometry.Item Synthesis, characterization and biological activity screening of metal (II) complexes of some nitrogen and dioxygen donor ligands(Ahmadu Bello University, Zaria, Nigeria, 2016-05-30) Owalude, S. O.; Tella, A.C.; Duntoye, M.R.; Adimula, V.O.; Eke, U. B.; Odebunmi, E.O.A series of Ni(II) and Cu(II) complexes of Schiff base ligands derived from 4-aminobenzoic acid, 2- aminophenol, salicylaldehyde and 1H-indole-2,3-dione have been synthesized and characterized by elemental analysis, FT-IR, UV-vis and NMR spectroscopic analyses. Elemental analysis data were in agreement with a metal:ligand ratio of 1:1 for the complexes formed with HL1, HL3 and HL4 in a tetrahedral geometry fashion while those with HL2 results in complexes with metal:ligand ratio of 1:2 in octahedral arrangement. The antimicrobial activity of the Schiff base ligands and their metal complexes were investigated on the strains of gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Salmonella typhi) as well as on the fungi strains (Candida albicans, Aspergillus niger, Rhizopus stolonifer and Penicillium notatum) using disc diffusion method. The results showed that the zones of inhibition of the metal complexes for both species were higher than that of the Schiff base ligands. This indicates that the metal complexes can be applied in drug design to control bacterial and fungal diseases.Item Transesterification Reaction of Palm Kernel Oil (PKO) on a Bed of Crushed Cashew Nut Shell (CCNS)(Usmanu Danfodiyo University, Sokoto, Nigeria, 2019-06-04) Eke, U. B.; Owalude, S.O.; Tella, A.C.; Adejoro, A.G.Biodiesel (GA1) was produced by the transesterification reaction of palm kernel oil (PKO) and methanol catalysed by crushed cashew nut shaft. Biodiesel samples GA2 – GA4 were also produced from the palm kernel oil using conventional base catalysis by NaOH and crushed cashew nut shaft combined with NaOH. The physico-chemical properties and spectroscopic data of the four samples were found to be similar and compared favourably to those of standard biodiesel.