An Evaluation of the Impact of Zinc and Copper Metal-Organic Frameworks (MOFs) on the Drug Release Profiles of Piroxicam
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Date
2020-05
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Publisher
Journal of Pharmaceutical Research, Development and Practice
Abstract
Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) poorly soluble in an aqueous medium with a slow and gradual dissolution in biological fluids resulting in sub-optimal efficacy in patients. In recent times, Metal-Organic Frameworks (MOFs), a new class of highly tenable hybrid porous materials with unique properties have been explored for usage as drug carriers and other biomedical applications. This study is aimed at studying the solubility, in vitro release profile and kinetics of piroxicam loaded Zinc and Copper Metal-Organic Frameworks. Piroxicam was loaded on Zinc and Copper MOFs and tested for its solubility, dissolution and drug release profile. The mechanisms of the release pattern of the drug from Zinc and Copper MOFs were analysed using kinetic models. At the end of the study, Piroxicam-loaded Zn MOFs had solubility of 161.34 ± 0.63 μg/mL, while that of Cu MOFs and pure piroxicam had solubility of 154.31 ± 1.27 μg/mL and 134.86 ± 0.48 μg/mL respectively. Within a period of 24 hours, Piroxicam had the highest release from Zn MOFs; with a drug release in the range of 43.70 to 99.10%. Piroxicam was released from the loaded Cu MOFs in the range of 41.20 to 78.3% while the release of pure Piroxicam was in the range of 37.50 to 49.0%. Mechanism of piroxicam release was by Fickian diffusion. Piroxicam was successfully loaded on Zinc and Copper MOFs. Zn MOFs demonstrated a better solubility and dissolution profile as compared to Cu MOFs. These study shows the drug delivery potentials of the Zinc and Copper MOFs in improving the solubility and drug release of piroxicam.
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KEYWORDS: piroxicam, solubility, zinc, copper, MOFs, drug release.
Description
An Experimental Study on the Potential of Using Metallic-Organic-Frameworks in Piroxicam Delivery
Keywords
Research Subject Categories::PHARMACY:: formulation science, Research Subject Categories::PHARMACY::Pharmaceutics, Research Subject Categories::PHARMACY::Biopharmacy, Research Subject Categories::ODONTOLOGY::Pharmacological research
Citation
Kola-Mustapha et al., 2020