Browsing by Author "Sulu-Gambari L."

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    Altered testicular histomorphometric and antioxidant levels following in vivo Bisphenol-A administration
    (School of Medicine, Arak University of Medical Sciences, 2021) Kadir R.E.; Ojulari L.S.; Gegele T.A.; Lawal I.A.; Sulu-Gambari L.; Sulaimon F.A.; Omotoso G.O.
    Background: Bisphenol-A (BPA) is a pervasive environmental toxin that is used in the production processes of many consumables and equipment that are in daily application. The aim of this study was to determine the effects of BPA on the structural and functional integrity of the reproductive system in male Wistar rats and its interaction with melatonin. Methods: Adult female rats in pro-estrus phases were mated with adult male rats and the conception determined. The male pups were divided into two groups of A and B. These groups were further subdivided into six subgroups each. They were administered varying low doses of BPA (25 or 50mg/kg) and melatonin (10mg/kg) at neonatal and adolescent ages. The testes, epididymis and blood samples were collected for histological, semen and biochemical investigations, respectively. Results: The results show that BPA caused histological alterations, reduced quality and quantity of sperm cells, and induced oxidative stress at birth and adolescence. Conclusion: Bisphenol A exposure, even at low dose, is toxic to the male reproductive system, and melatonin administration did not significantly improve the alterations caused by the BPA
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    Comparative oestrogenic effects of Allium sativum and Allium cepa in ovariectomised rats
    (Association of Anatomical Societies of Africa, 2022) Kadir R.E.; Ojulari L.S.; Lawal I.A.; Sulu-Gambari L.; Hussein A/; Hamza A.; Aliagan I.A.; Oyewole L.A.
    Oestrogens are steroid hormones that influence the growth, differentiation, and functioning of many target organs, including the male and female reproductive organs. Menopause, an important sign of aging in women is characterized by oestrogen depletion, which is associated with many menopausal problems. Oestrogen supplements that are mostly used are not readily safe and have been reported to cause serious health hazards Phytoestrogens are plant compounds that are essentially correspondent to oestradiol (17-β oestradiol) and can relate with oestrogen receptors to elevate and/or prohibit oestrogenic responses. This study therefore aimed at evaluating the possible therapeutic efficacy of Allium sativum and Allium cepa on oestrogenic activities of adult ovariectomised wistar rats. Adult Wistar rats were ovariectomized, then administered various doses of the extracts for 28days, then sacrificed and tissues harvested for analysis. Results shows Allium cepa and quercetin to increase endometrial thickness, increase neural cells in synaptophysin stained cells of hippocampus and dentate gyrus. A conclusion of Allium cepa possessing similar estrogenic properties as estradiol group in these ovariectomized rats was drawn, which can offer some ameliorative effects of estrogen deficiency.
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    Comparative oestrogenic effects of Allium sativum and Allium cepa in ovariectomised rats
    (Association of Anatomical Societies of Africa, 2022) Kadir R.E.; Ojulari L.S.; Lawal I.A.; Sulu-Gambari L.; Hussein A.; Hamza A.; Aliagan I.A.; Oyewole L.A.
    Oestrogens are steroid hormones that influence the growth, differentiation, and functioning of many target organs, including the male and female reproductive organs. Menopause, an important sign of aging in women is characterized by oestrogen depletion, which is associated with many menopausal problems. Oestrogen supplements that are mostly used are not readily safe and have been reported to cause serious health hazards Phytoestrogens are plant compounds that are essentially correspondent to oestradiol (17-β oestradiol) and can relate with oestrogen receptors to elevate and/or prohibit oestrogenic responses. This study therefore aimed at evaluating the possible therapeutic efficacy of Allium sativum and Allium cepa on oestrogenic activities of adult ovariectomised wistar rats. Adult Wistar rats were ovariectomized, then administered various doses of the extracts for 28days, then sacrificed and tissues harvested for analysis. Results shows Allium cepa and quercetin to increase endometrial thickness, increase neural cells in synaptophysin stained cells of hippocampus and dentate gyrus. A conclusion of Allium cepa possessing similar estrogenic properties as estradiol group in these ovariectomized rats was drawn, which can offer some ameliorative effects of estrogen deficiency.