Browsing by Author "Soladoye, A.O."

Now showing 1 - 7 of 7
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    Comparative Study of the Effects of Whole Milk and Soymilk Extenders on Semen Quality and Period of Storage
    (Taraba Journal of Agricultural Research, Faculty of Agriculture, Taraba State University, 2015-12) Okukpe, Kehinde Matthias; Adeloye, Abiodun Adefunmilayo; Soladoye, A.O.
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    Effects of Nigella sativa aqueous extract on some haematological parameters, lipid peroxidation and osmotic fragility changes in alloxan induced diabetic rats
    (College of Health Sciences, University of Ilorin, Nigeria, 2010) Ayinla M.T; Soladoye, A.O.; Olayaki, L.A.; Suleiman, S.O.
    This study was designed to investigate the effect of extracts of Nigella sativa on some haematological values, lipid peroxidation and osmotic fragility changes in alloxan-induced diabetic rats. Eighteen albino rats were divided into 3 experimental groups of six rats each; control, diabetic untreated, diabetic treated with aqueous extract of Nigella sativa. At the end of experimental period (Four weeks) animals in all the groups were fasted for 12 hours and blood samples were taken for the determination of red blood cell count (RBC), packed cell volume (PCV), Haemoglobin concentration (Hb). In addition Malondialdehyde (MDA, marker of lipid peroxidation) and erythrocytes osmotic fragility test were carried out. In diabetic untreated rats, the PCV, RBC, Hb. were decreased, but application of the extract significantly increased the values (P<0.05, n=6). Similarly, treatment with aqueous extract of Nigella sativa decreased the elevated Malondialdehyde level (P<0.05, n=6) of diabetic rats. The results also showed that Nigella sativa extract significantly reduced the MCF50 from 0.68% to 0.50% (P<0.05 n=6). These findings suggest that Nigella sativa extract might improve the diabetic-induced disturbances of some haematological parameters by decreasing the elevated lipid peroxides and susceptibility of red blood cell to haemolysis.
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    Effects of Varying Levels of Mucuna pruriens Extract on Reproductive Performance of West African Dwarf Bucks
    (Centrepoint Journal (Science Edition), University of Ilorin, Nigeria, 2014-12) Okukpe, Kehinde Matthias; Adeloye, Abiodun Adefunmilayo; Soladoye, A.O.
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    Evaluation of Antimalarial and Toxicity Potentials of Methanolic fraction of cocos nucifera (West African Tall variety) husk fibre extract in animal models
    (Parasitology and Public Health Society of Nigeria, 2013-03) Ugbomoiko, U.S.; Awoniyi, M.A.; Balogun, E.A.; Malomo, S.O.; Soladoye, A.O.; Adebayo, J.O.; Kolawole, O.M.; Oguntoye, O.S.; Olatunji, L.A.; Babatunde, A.S.; Akinola, O.B.
    The antimalarial and toxicity potentials of the methanolic fraction of Cocos nucifera (West African tall variety) husk fibre extract were investigated using animal models. For the 4-day suppressive antimalarial test, thirty Plasmodium berghei NK65-infected mice were randomly divided into six groups (A-F) with five mice each. Mice in group A (control) received orally appropriate volume of distilled water while those in group B were orally administered chloroquine (20 mg/Kg body weight) for three days post-inoculation. Mice in groups C-F were orally administered 62.5, 125, 250 and 500 mg/Kg body weight of the extract fraction for three days post-inoculation. For toxicological studies, twenty albino rats were randomly divided into four groups (G-J) with five rats each. Rats in group G (control) were orally administered appropriate volume of distilled water while those in groups H-J were orally administered 25, 50 and 100 mg/Kg body weight of the extract fraction respectively for fourteen days. At the end of the experimental period, venous blood was collected and selected tissues isolated and homogenized. The full blood count and activities of alkaline phosphatase, aspartate and alanine aminotransferase in the tissues were determined. The results revealed that the methanolic fraction of C. nucifera (West African Tall variety) husk fibre extract does not possess any antimalarial activity. The extract, at all doses administered, had no significant effect (P>0.05) on the red blood cell indices, white blood cell indices and the activities of all the enzymes in the liver, kidney, heart and brain compared to controls. The results thus suggest that the methanolic fraction of the husk fibre extract may not be responsible for the acclaimed antimalarial action of C. nucifera (West African Tall variety) husk fibre, though it may not aggravate the severity of the disease.
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    In vivo Antimalarial Activity and toxicological effects of methanolic extract of Cocos nucifera (Dwarf Red Variety) husk fibre
    (Shanghai Association of Integrative Medicine, China, 2014) Balogun, E.A.; Malomo, S.O.; Adebayo, J.O.; Ishola, A.A.; Soladoye, A.O.; Kolawole, O.M.; Oguntoye, O.S.; Babatunde, A.S.; Akinola, O.B.
    Abstract Phytochemical constituents as well as antimalarial and toxicity potentials of the methanolic extract of the husk fibre of Dwarf Red variety of Cocos nucifera were evaluated in this study.The dried powdered husk fibre was exhaustively extracted with hexane, ethyl acetate and methanol successively and the methanolic extract was screened for flavonoids, phenolics, tannins, alkaloids, steroids, triterpenes, phlobatannins, anthraquinones and glycosides. A 4-day suppressive antimalarial test was carried out using Plasmodium berghei NK65-infected mice, to which the extract was administered at doses of 31.25, 62.5, 125, 250 and 500 mg/kg body weight (BW). Toxicity of the extract was evaluated in rats using selected hematological parameters and organ function indices after orally administering doses of 25, 50 and 100 mg/kg BW for 14 d.Phytochemical analysis revealed the presence of alkaloids, tannins, phenolics, saponins, glycosides, steroids and anthraquinones in the extract. Moreover, the extract reduced parasitemia by 39.2% and 45.8% at doses of 250 and 500 mg/kg BW respectively on day 8 post-inoculation. Various hematological parameters evaluated were not significantly altered (P>0.05) at all doses of the extract, except red blood cell count which was significantly elevated (P<0.05) at 100 mg/kg BW. The extract significantly increased (P<0.05) urea, creatinine, cholesterol, high-density lipoprotein-cholesterol and bilirubin concentrations in the serum as well as atherogenic index, while it reduced albumin concentration significantly (P<0.05) at higher doses compared to the controls. Alanine aminotransferase activity was reduced in the liver and heart significantly (P<0.05) but was increased in the serum significantly (P<0.05) at higher doses of the extract compared to the controls.The results suggest that methanolic extract of the Dwarf red variety has partial antimalarial activity at higher doses, but is capable of impairing normal kidney and liver function as well as predisposing subjects to cardiovascular diseases.
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    Sexual Response and Semen Characteristics of West African Dwarf Bucks Subcutaneously Administered with a Polyherbal Extract
    (Production, Agriculture and Technology, Nasarawa State University, 2018) Okukpe, Kehinde Matthias; Adeloye, Abiodun Adefunmilayo; Soladoye, A.O.; Adua, Mango M.; Adeyina, Adebisi Olusegun; Alli, Oluwasayope Ibidapo; DeCampos, John Sunday; Osho, Bamidele
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    Triglyceride/HDL-cholesterol ratio and plasminogen activator inhibitor-1 independently predict high pulse pressure in sickle cell trait and disease
    (Taylor & Francis, 2020) Olabode, O.P.; Akinlade, O.M.; Babatunde, A.S.; Abdulazeez, M.I.; Biliaminu, S.A.; Oyabambi, A.O.; Olatunji, V.A.; Soladoye, A.O.; Olatunji, L.A.
    ABSTRACT We hypothesised that TG/HDL-C ratio and PAI-1 would be associated with high pulse pressure (PP) in young adults with sickle cell trait (SCT) and sickle cell disease (SCD). We compared the clinical, biochemical, and cardiometabolic parameters among individuals with normal genotype (HbAA; n¼60), SCT (HbAS; n¼60), and SCD (HbSS; n¼60), all in steady state. Using multivariate linear regression analysis, high PP was positively related to TG/HDL-C ratio in SCT (b¼0.307; p¼.014) and PAI-1 (b¼0.499; p¼.001) in SCD. The curve of receiver operating characteristic also showed that TG/HDL-C ratio and PAI-1 are efficient predictors of high PP in SCT carriers and SCD patients, respectively. This study suggests that increased levels of TG/HDL-C ratio and PAI-1 may be salient risk factors that would promote the development of arterial stiffness and other CVD in SCT carriers and SCD patients.