Browsing by Author "Soladoye, A.O"

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    Antimalarial Activity of Cocos nucifera Husk fibre: Further Studies
    (Hindawi Publishing Corporation, 2013) Adebayo, J.O.; Balogun, E.A.; Malomo, S.O.; Soladoye, A.O; Olatunji, L.A.; Kolawole, O.M.; Oguntoye, O.S.; Babatunde, A.S.; Akinola, O.B.; Aguiar, A.C.C; Andrade, I.M.; Souza, N.B.; Krettli, A.U.
    Abstract In this study, the antimalarial and toxicity potentials of husk fibre extracts of five Nigerian varieties of Cocos nucifera were evaluated in vitro. The only active extract fraction, West African Tall (WAT) ethyl acetate extract fraction, was then evaluated for its phytochemical constituents, antimalarial and toxicity potentials at varying doses (31.25–500 mg/kg body weight) using various organ function indices. The results revealed that WAT ethyl acetate extract fraction (WATEAEF) contained alkaloids, tannins, and flavonoids and was active against Plasmodium falciparum W2 strain maintained in continuous culture, with a selectivity index of 30.3. The same extract fraction was active in vivo against Plasmodium berghei NK65, causing more than 50% reduction in parasitaemia on days 4 and 6 after inoculation at various doses administered. WATEAEF did not significantly alter ( ) function indices of the liver and cardiovascular system at all doses administered but significantly increased ( ) plasma creatinine concentration at 250 and 500 mg/Kg body weight compared to controls. The results of this study suggest that WATEAEF possesses antimalarial activity and may not adversely affect normal liver function nor predispose subjects to cardiovascular diseases but may impair normal kidney function at higher doses. Further studies are underway to isolate the active principles.
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    Determination of glomerular filtration rate using cystatin C in healthy Nigerian newborns
    (Faculty of Medicine, Alexandria University, Alexandria, Egypt, 2019) Ibrahim, O.R.; Soladoye, A.O; Adeodyin, O.T; Mokuolu, O.A.; Abdulkadir, Mohammed Baba; Biliaminu, S.A.
    Background: The value of Cystatin C as a biomarker of Glomerular filtration rate (GFR) among African newborns is unknown, due to paucity of studies, restricting the measurement of GFR in this population of newborns to creatinine clearance despite its limitations. This study was therefore conducted to estimate GFR from serum Cystatin C in a population of Nigerian newborns and explored the relationship with anthropometrics. Methods: This was a cross-sectional, analytical study. A total of 60 healthy preterm and 30 healthy term babies were recruited at a tertiary hospital in North-central, Nigeria. Serum Cystatin C was determined using ELISA according to standard methods. Anthropometric measurements were done with standard methods. The GFR was estimated using Zappitelli’s equation. Data were analyzed using SPSS Version 20, and p-value < 0.05 was considered significant. Results: Mean serum Cystatin C was 1.20 ± 0.33 (range 0.80–2.20) mg/L with comparable values in males and females (1.19 ± 0.35 vs 1.15 ± 0.31 mg/L, p = 0.481)). Mean serum Cystatin C among preterm babies were higher than term babies (1.31 ± 0.36 vs 1.01 ± 0.11 mg/L, p = < 0.001). Mean estimated GFR was 65.36 ± 16.9 ml/min/1.732 and was comparable in males and females (64.39 ± 17.95 vs 66.52 ± 15.76 ml/min/1.73 m2 ,p = 0.555). Estimated GFR was lower among preterm than term babies (60.10 ± 17.53 vs 75.89 ± 9.1 ml/min/1.73 m2 , p = < 0.001). Serum cystatin C and estimated GFR moderately correlated with gestational age and anthropometrics (length, occipitofrontal circumference and weight). Conclusions: Serum cystatin C as a biomarker GFR among newborns is low compared with most studies done out of Africa. The serum cystatin C and estimated GFR correlated with the gestational age and anthropometric parameters. The findings relationship between the serum Cystatin C, estimated GFR and anthropometrics among the newborns suggested a need for more studies.
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    In-vivo Antimalarial Activity and toxicological effects of methanolic extract of Cocos nucifera (Dwarf Red Variety) husk fibre
    (2014) Balogun, E. A; Malomo, S.O; Adebayo, J.O; Ishola, A.A; Soladoye, A.O; Babatunde, A.S.; Akinola, O.B.
    We performed a single center retrospective analysis of 84 autologous hemopoietic stem cell transplants done for AML to characterize the pattern of hemopoietic engraftment, post-transplant cytopenia and their impact on survival outcome. Following autologous transplant and engraftment, 30 patients (35.7%) had a transient secondary decline in their plt counts, which was not associated with graft rejection, relapse or infection. The median time to onset of thrombocytopenia was 59 days post transplant, with spontaneous recovery after a median period of 41 days. A secondary decline in ANC also occurred in eight patients. Patients with secondary plt decline had a significantly earlier primary plt engraftment (median 15 days) and a trend towards earlier neutrophil engraftment compared with patients who maintained steady plt counts (median 21 days). There was a trend towards a lower incidence of secondary plt decline in patients who received BM stem cells compared with those who received PBSC. No cause was evident for the occurrence of a secondary cytopenia, and it did not adversely affect survival. We conclude that secondary cytopenia is a common and harmless occurrence after autologous transplant especially from PBSC graft. Bone Marrow Transplantation (2009) 44, 175–183; doi:10.1038/bmt.2009.1; published online 9 February 2009 Keywords: acute myeloid leukemia; autologous hemopoietic stem cell transplant; engraftment kinetics; secondary platelet decline; secondary cytopenia Introduction AML refers to a group of clonal hemopoietic stem cell disorders, which are characterized by failure of differentiation and excessive proliferation of the stem cells leading to accumulation of non-functional immature myeloblasts, both in peripheral blood and BM. Anthracycline-based chemotherapeutic regimens, which are conventionally given for induction of remission, are known to produce CR in about 60–80% of patients.1–3 However, despite the initial good response by the myeloblasts to these agents, they are usually associated with a high rate of resistance and relapse, and it has been reported that majority of AML patients who achieve CR following induction will relapse within 12–24 months, and only about 7–34% will be alive and disease free by 5 years after diagnosis.4–6 Autologous hemopoietic SCT (AHSCT) has therefore been used in AML either as a component of consolidation following the initial CR or as part of salvage therapy for patients in second remission to improve the poor prognosis associated with chemotherapy alone.7–9 AHSCT has also been used for AML patients who do not immediately have matched allogeneic donors and in elderly patients who are above 60 years of age.10 The pattern of engraftment and hemopoietic recovery following
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    Sex-related differences in clinical, electrocardiographic, and echocardiographic indices among normotensive offspring of black parents with hypertension.
    (Faculty of Medicine, Ahmadu Bello University, Zaria, Nigeria, 2017) Kolo, P.M.; Sanya, E.O.; Omotoso, A.B.; Soladoye, A.O; Ogunmodede, James Ayodele
    Context: Blood pressure tracking has suggested that the difference in blood pressure between women and men begins to manifest during the adolescent period. It is therefore postulated that sex-related cardiac structural and functional differences that could predict future events may exist in the heart of offspring of parents with hypertension. Aims: This study aimed at evaluating the effects of sex difference on the heart of offspring of parents with hypertension. Settings and Design: Cross-sectional study. Participants and Methods: A group of offspring of parents with hypertension aged between 15 and 25 years were recruited for the study if they had normal blood pressure and gave consent. They had clinical, electrocardiography, and echocardiographic assessments. Results: Sixty-five participants consisting of 47 males and 18 females participated in the study. Mean systolic blood pressure was higher (P = 0.001) in the males compared with the females but the diastolic blood pressure was similar between them. Electrocardiogram (ECG) parameters (heart rate, QRS axis and QTc) were similar between the males and the females but the summation of ECG voltage (SV2 + RV6) was higher in the former than the latter. Left ventricular (LV) posterior wall (P = 0.001), aortic root diameter (P = 0.014), LV mass (P = 0.001), LV mass index (P = 0.001), and relative wall thickness (P = 0.003) were higher in the male compared with the female participants, respectively. However, more females (72.2%) had normal LV geometry compared with the males, P = 0.03. Conclusion: There are subtle clinical, electrocardiographic, and echocardiographic differences between the heart of male and female offspring of parents with hypertension with the former having more precursors of future cardiovascular events.