Browsing by Author "Sanni, E.O."

Now showing 1 - 5 of 5
  • Item
    Clinico-Pathologic features and outcome of Chronic Lymphocytic Leukemia in Ilorin, North Central Nigeria
    (College of Health Sciences, University of Ilorin, 2020) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K.; Owoeye, O.A.; Sanni, E.O.
    Abstract: A retrospective analysis of all patients that were diagnosed and managed for Chronic lymphocytic Leukemia(CLL) in the Department of Haematology of University of Ilorin Teaching Hospital, Ilorin between 1st January 2005 and 31st December 2018 was carried out with the aim of characterizing the clinical, haematological and prognostic features as well as outcome in the patients. A total of 39 patients were reviewed consisting 25(64.1%) males and 14(35.9%) females giving a M:F ratio of 1.6:1. The median age of patients at diagnosis was 65.5 years and the highest prevalence was found in the 60 – 69 years age group. The commonest symptoms at presentation were night sweats (59.0%), Body weakness (51.3%), fever (41.0%), and weight loss (41.0%) while the commonest signs included lymphadenopathy in all patients (100%), splenomegaly (87.2%), pallor (53.9%) and hepatomegaly (46.2%). The mean values of haematological parameters were: Packed cell volume (28.6%), Haemoglobin concentration (9.4g/dL), Total white blood cell count (87.6 x 109/L), Absolute lymphocyte count (55.8 x 109/L) and platelet count (134.8 x 109/L). The majority of the patients (94.9%) were diagnosed with advanced disease (Rai stage III and IV) while only 2(5.1%) had Rai stage II and none in Rai stage 0 – I. Chlorambucil-based regimen was used in 71.8% of patients, and only 2 patients had Rituximab as part of their treatment regimen. The clinical presentation, haematological features and disease outcome observed in our study was similar to what had been reported in Nigeria and other parts of the world.
  • Item
    Current Trend of Transfusion Transmissible Infections among Voluntary Blood Donors in North Central Nigeria
    (College of Health Sciences, University of Ilorin, 2021-07) Durotoye, I.A.; Salaudeen, A.G.; Sanni, E.O.; Durowade, K.A.; Babatunde, A.S.; Olawumi, H.O.; Akande, T.M.; Musa, I.O.
    Blood transfusion is an integral part of modem medicine which had saved many lives which would have been lost as a result of lack of blood. Although blood is needed for survival, it can also be a medium for the transmission of harmful infectious diseases. This study evaluated current trend of transfusion transmissible infections among voluntary blood donors in Nigeria. This was a descriptive community-based study involving 600 prospective voluntary blood donors among staff and students of 5 tertiary institutions in Kwara and Kogi States. Hepatitis B surface antigen and Hepatitis C antibodies were screened for using Hepatitis B Virus Surface Antigen Bio-Inteco ELISA KIT, and Anti-HCV Bio-Inteco ELISA KIT, respectively. Screening for HIV was done with Enzyme immunoassay method using Human Immunodeficiency Virus (HIV) 1+2 Antigen Antibody ELISA KIT, product of Bio-Inteco HIV Diagnostics, UK. Testing for Syphilis was carried out using Rapid Plasma Reagin (RRR) test. Statistical analysis was done with IBM SPSS version 20. Level of significance was set at p< 0.05 The mean age of the subjects was 21.98 ± 5.17 years. Two thirds of the prospective blood donors were within the second decade of life and more than half were males. The prevalence of Hepatitis B among subjects were 4.7%, Hepatitis C,0.2%, HIV 1% and Syphilis 0%. The prevalence of hepatitis B and HIV were relatively high compared to Hepatitis C and Syphilis among voluntary blood donors, although lower than the prevalence among general population in Nigeria. In order to improve on blood transfusion safety, there is a need to increase public awareness on vaccination for hepatitis B virus, Quality control of screening methods and rational use of Blood.
  • Item
    Evaluation of the Clinico-haematological Characteristics and Pattern of Presentation of Acute Myeloid Leukemia in Ilorin, North Central Nigeria.
    (Ambrose Alli University, Ekpoma, 2020) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K.; Owoeye, O.A.; Sanni, E.O.
    Acute myeloid leukemia (AML) is a malignant haematologicaldisorder of the myeloid lineage in the bone marrow resulting from clonal proliferation of haemopoietic progenitor cells with accumulation of myeloblasts in the blood, bone marrow and tissue infiltration. The aim of this retrospective study was to determine the pattern of presentation, clinical features and haematological parameters of AML patients diagnosed at the Haematology Department of U.I.T.H, Ilorin between 1" January 2008 and 31“ December 2018. The study materials included Bone marrow registers from the department and case folders of all AML patients diagnosed within the study period. Relevant data including socio-demographic characteristics of patients, clinical features at presentation and laboratory tests results were extracted, documented and analyzed. Diagnosis of AML was made based on the findings of 20% blasts in the bone marrow and/or peripheral blood and classified using FAB classification criteria.There were forty-six patients and their median age at diagnosis was 20.6 + 15.9 years.The highest prevalence of the disease was found in the 11 — 20 years age group.The most common presenting symptoms were fever (91.3%), pallor (84.8%), bleeding diasthesis (52.2%), and body weakness (45.7%).The mean+SD values of haematological parameters in the patients wer—e PCV (19.9+5.8%), Hb cone. (6.6+1.9 g/dL), Total WBC (48.1+54.8 x 10’/L) and Platelet Count (39.6+24.0 x 10’/L).The commonest subtype of AML in our study was M4 which was seen in 26 (56.5%) patients, followed by M5 observed in 10 (21.7%) patients. In resource-limited settings such as ours, the diagnosis and monitoring of patients with AML still rely on the clinical and laboratory features of the disease to a large extent, hence the need for Haemato-oncologists and Physicians to be conversant with these features.
  • Item
    Pattern of Haematological Changes in Patients with Chronic Kidney Disease Attending Nephrology Clinic in a Tertiary Hospital in North Central Nigeria
    (Amber Publication Ltd, 2020) Sanni, E.O.; Olawumi, H.O.; Durotoye, I.A.; Babatunde, A.S.; Shittu, A.O.; Biliaminu, S.A.; Omokanye, K.O.; Ogunfemi, M.K.; Akinwumi, O.O.; Oyedepo, D.; Dane, S.
    Introduction: The impact of the disease of the kidney is enormous in developing countries like Nigeria. With the increasing use of erythropoietin stimulating agents in anaemic patients with CKD, there is a need to evaluate the changes in haematological parameters in these patients. This study assessed the haematological changes in patients with known chronic kidney disease. Materials and methods: Our research was a cross-sectional study that assessed and compared the haematologic parameters of 113 patients who had established chronic kidney disease and 113 -healthy controls who were age–and sex-matched. The full blood count (FBC) was determined by SysmexKX21(Sysmex, Japan). The test of significance was set at a P- value of <0.05. Results and Discussion: The mean age of patients with CKD was 55.00 + 15.37 years, whilst that of controls was 52.73±13.59 years. (p-value 0.240) The values of the mean of the Hb and RBC among the patients were 9.69+ 2.25g/dl and 3.62 ± 0.92 x 1012/L respectively and were found to be significantly lower than that seen among controls (13.62 ± 1.45 and 4.94 ± 0.62 respectively) with a P-value<0.001. Significantly higher values of the mean WBC and platelet count were found in the patients when compared with the control participants (p-value<0.001). A significant proportion of our patients had microcytic hypochromic anaemia (32%). Conclusion: Careful evaluation of the cause of anaemia and urgent interventions are needed in the managements of these patients.
  • Item
    Pattern of neurological complications of chronic myeloid leukaemia in Ilorin, Nigeria: A ten year review
    (Faculty of Clinical Sciences, College of Medicine, Ambrose Alli University, 2018) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Sanni, E.O.; Oyeleke, S.A.
    Aim and Objective: The study was carried out to document the pattern of neurological complications seen in patients with chronic myeloid leukemia who were managed at the University of Ilorin Teaching Hospital, Ilorin and compare with previous reports from other parts of Nigeria and elsewhere. Materials and Methods: A ten year retrospective analysis of all cases of CML managed at the study centre between January 2006 and December 2015 was carried out. Case folders of all patients diagnosed with CML during the study period, and the Malignancy registers of the Haematology department were retrieved and analyzed. Relevant information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. Results: Thirty six (36) patients were diagnosed with CML during the study period. There were 21 (58.3%) males and 15 (41.7%) females, giving a male: female ratio of 1.4:1.The mean age of the patients at diagnosis was 37.5 years (range, 11-75 years). Nine (25%) patients presented with various forms of neurological complications and the mean WBC count in them was 383.2 x 109/L (280.5 601.0 x 109/L). Auditory complications were the commonest neurological deficits found in 6(66.7%) of the 9 patients with neurological manifestations. Conclusion: The neurological complications recorded in this study were similar to those reported in previous studies from Nigeria and other countries. These complications need to be looked for at presentation and adequately characterized as their presence could significantly influence the prognosis of the disease and decisions on management modalities.