Browsing by Author "Sani, M.A."

Now showing 1 - 4 of 4
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    Haematological Parameters of Normal Pregnant Women During Antenatal Clinic Booking in Ilorin, North Central Nigeria
    (Ambrose Alli University, 2017) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Adesina, K.T.; Sani, M.A.; Nyamgee, A
    Alterations in the values of some haematological parameters like packed cell volume and haemoglobin concentration during pregnancy have been reported to significantly influence pregnancy outcome. The aim of this study was to determine the values of haematological parameters in apparently healthy pregnant women during the antenatal clinic booking visit at the University of Ilorin Teaching Hospital, Ilorin, North central Nigeria. A total of 298 apparently healthy pregnant women who presented for antenatal care booking and satisfied the inclusion criteria were included in the study. There were 64 (21.5%) women in first trimester, 146 (49.0%) women in second trimester and 88 (29.5%) in third trimester; and were aged between 22 and 42 years. Packed cell volume, haemoglobin concentration, Red cell count, mean haemoglobin concentration, mean corpuscular volume, mean corpuscular haemoglobin concentration, Total white blood cell count and differentials, Platelet count and erythrocyte sedimentation rate were carried out in the subjects. The overall mean values and SD of the pregnant women for the haematological parameters were as follows: PCV (32.76±2.18%), Hb (10.82±0.77g/dl), RBC (3.87±2.32 x1012/L), MCH (28.08±2.06 pg), MCV (85.16±5.82 fl), MCHC (33.01±1.05 g/dl), TWBC (7.35±2.62 x109/L), Platelet count (192.15±62.80 x109/L) and ESR (34.07±16.85 mm/hr). There were statistically significant differences in the mean values of PCV, MCH and MCV with increasing gestational age (p<0.05). Conclusion: The present study provides a baseline data on the haematological values in pregnancy in the North central zone of the country on which further large scale studies in future may be based. This study will also be of immense benefit in the monitoring of pregnant women to determine those at risk for timely intervention thereby improving pregnancy outcome.
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    The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria
    (Hindawi Publishing Corporation, 2015) Sani, M.A.; Adewuyi, J.O.; Babatunde, A.S; Olawumi, H.O; Shittu, R.O.
    Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in theworld. It is characterized by anaemia, periodic attacks of thrombotic pain, and chronic systemic organ damage. Recent studies have suggested that individuals with SCA especially from developing countries are more likely to be iron deficient rather than have iron overload. The study aims to determine the iron status of SCA patients in Ilorin, Nigeria. Methods. A cross-sectional study of 45 SCA patients in steady state and 45 non- SCA controls was undertaken. FBC, blood film, sFC, sTfR, and sTfR/log sFC index were done on all subjects. Results. The mean patients’ serum ferritin (589.33 ± 427.61 ng/mL) was significantly higher than the mean serum ferritin of the controls (184.53 ± 119.74 ng/mL).Themean serum transferrin receptor of the patients (4.24 ± 0.17 𝜇g/mL) was higher than that of the controls (3.96 ± 0.17 𝜇g/mL) (𝑝 = 0.290). The mean serum transferrin receptor (sTfR)/log serum ferritin index of the patients (1.65 ± 0.27 𝜇g/mL) was significantly lower than that of the control (1.82 ± 0.18 𝜇g/mL) (𝑝 = 0.031). Conclusion. Iron deficiency is uncommon in SCA patients and periodic monitoring of the haematological, biochemical, and clinical features for iron status in SCA patients is advised.
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    Malaria Parasitaemia and Anaemia among First Antenatal Clinic Attendees in Ilorin, Nigeria
    (Pan Africa Medical Journal, 2010) Fadeyi, A.; Balogun, O.R.; Babatunde, A.S.; Adesina, K.T.; Aderibigbe, S.; Sani, M.A.
    The burden of malaria and anaemia in pregnancy is unknown in Ilorin, Nigeria despite malaria being threat to 2.4 billion lives world-wide including Nigerians particularly the children and pregnant women. To determine the prevalence of malaria parasitaemia and anaemia in pregnancy among first antenatal clinic attendees at the University of Ilorin Teaching Hospital (UITH), Ilorin, Nigeria, 500 consecutive, consenting pregnant women presenting for antenatal care at UITH, Ilorin for the first time were screened for malaria parasitaemia and anaemia over a 1 year period starting from June 2008. Information about participants’ socio-demographic data, fever, anti-malaria therapy including prophylaxis using intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp/SP) among others were also obtained at recruitment. The prevalence of malaria parasitaemia and anaemia in the women were 32.4% and 25.8 respectively. The women’s age, parity and educational level did not affect either malaria parasitaemia (MP) or mean parasite density (MPD) but gestational age (GA) significantly (F = 6.02, p = 0.002) affected MPD as women in the first trimester (35.7%) were most infected. The mean haemoglobin concentration (MCH) was significantly associated with maternal age (f = 3.33, p = 0.005) and parity ((f – 23.97, p = 0.000), and varied inversely as the MPD. Maternal fever was not a good predictor of MP as only 7 (46.7%) of 162 (32.4%) malaria parasitaemic women were febrile. There was no significant difference (f = 1.4, p = 0.23) in the mean malaria parasite densities of anaemic compared with non-anaemic women but there was significant difference in the prevalence of MP (X2 = 1.135, p = 0.0007549) and anaemia (X2 = 8.634, p = 0.0000) among users and non-users of IPTp/SP. Malaria parasitaemia and anaemia remains a threat in pregnancy in Ilorin, Nigeria with the affected often afebrile. Since users of IPTp/SP in pregnancy were better protected against malaria parasitaemia and anaemia in pregnancy, early antenatal booking and use of IPTp/SP is desired.
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    Serum C-reactive protein and cholesterol as predictors of severity in childhood Falciparum malaria infestation among Nigerians
    (Faculty Board of Pathology, National Postgraduate Medical College of Nigeria, 2012) • Biliaminu, S.A.; Shittu, A.O.; Olatunbosun, L.O.; Abdulazeez, I.M.; Sani, M.A.; Okesina, A.B.; Akande, A.A.; Omokanye, K.O.; Ojulari, L.S.
    Background: C-Reactive Protein (CRP) is a highly sensitive marker of acute inflammation and has been observed to rise significantly during malaria infections. It is valuable both diagnostically and epidemiologically. In contrast, red cell cholesterol, though not affecting membrane function, may impede malaria invasion. Traditional methods of grading malaria severity using parasite count have limitations, necessitating alternative indicators. Materials and Methods: The study involved 120 pediatric patients with acute malaria, categorized into mild, moderate, and severe groups (40 each). CRP and cholesterol levels were measured and correlated with malaria parasite count and severity. Results: Mean ages for the mild, moderate, and severe groups were 10.3, 7.1, and 3.8 years, respectively. CRP levels increased significantly, while cholesterol levels decreased with increasing malaria severity. CRP positively correlated with parasite count and scoring, while cholesterol showed a negative correlation. Conclusion: Serum CRP is a reliable indicator of malaria severity. Cholesterol also serves as a potential severity marker, although less prominently. These markers may aid diagnosis and therapeutic monitoring of falciparum malaria.