Browsing by Author "Salawu, M.K"

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    Evaluation of anti-nociceptive and anti-inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth
    (Pakistan Journal of Pharmaceutical Scences, 2019-01) Ayanniyi, R.O; Ojuade, F.I; Olumoh-Abdul, H.A; Salawu, M.K; Olufadi-Ahmed, Haishat; Adebisi-Jose, O. Gbemisola
    The leaf extract of Turraea vogelii Hook. f. ex. Benth. is used in ethnomedicine for the management of pain and inflammation. Anti-nociceptive activity was determined using acetic acid-induced mouse writhing model. The anti￾inflammatory activity was investigated using in-vitro bovine serum albumin (BSA) denaturation assay and BSA-induced hind paw edema in rats. The extract (125-500 mg/kg) administered via the oral route produced a significant (p<0.005) inhibition of acetic acid-induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and diclofenac (10 mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10-6 -1.0 µg/mL) inhibited protein denaturation with IC50values of (1.06 × 10-3 µg/mL and 2.58 × 10-3 µg/mL) for extract and diclofenac respectively. Furthermore, the leaf extract (62.5 mg/kg) significantly (p<0.05) inhibited BSA-induced paw edema in rats. The methanol leaf extract of T. vogelii has anti-nociceptive and anti-inflammatory activities. These findings justify the use of the plant in traditional medicine for the management of pain and inflammation.