Browsing by Author "Olumoh-Abdul, Hidayah"

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    Active Learning in a Pharmacology Classroom (Pharmacology Education l)
    (Federation Societies of Experimental Biology (FASEB), 2019) Ayanniyi, Rashidat Oluwafunke; Olumoh-Abdul, Hidayah
    Pharmacology teaching in Nigeria is extremely teacher-centered and does not meet the educational needs of Pharmacy students. Despite the numerous advantages of active learning, Pharmacy schools in Nigeria are yet to adopt this teaching method. This action research was carried out to introduce and determine the effectiveness of active learning in a pharmacology classroom. Twenty-four Pharmacy students in their third year participated in the study. Randomized control-group pre-test post-test design was used. A pre-test was administered to the control and treatment groups. Traditional lecture method was employed in teaching twelve students (control group) while three active learning strategies; Think-pair-share, Student presentation and Socratic questioning was used in teaching a cardiovascular module to twelve students (treatment group). A Post-test was given to both groups after four weeks of instruction. We administered a structured questionnaire to obtain information on students’ perception of active learning strategies. A higher mean score was obtained from the post-test of students taught with active learning strategies. Majority of the respondents agreed active learning enhanced team work, increased their knowledge and confidence. Inadequate pre-class preparation by the students was a major barrier encountered with use of active learning strategies and more time will be required to depart from passive to active learning. In conclusion, students were involved in the learning process and effective instruction was achieved. These findings will be of value to educators who plan to adopt active learning strategies in small classrooms.
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    Evaluation of Nutraceutical content and Topical Anti-inflammatory Activities of Turraea vogelii Hook F. Ex Benth (Meliaceae)
    (Arak University of Medical Sciences, 2019) Olumoh-Abdul, Hidayah; Ayanniyi, Rashidat; Ojuade, Fatimoh; Agbana, Remilekun
    Background: Turraea vogelii has been used as traditional medicine for the treatment of ailments including wounds, stomach aches, malaria, infections, filariasis cutaneous, among others and, it serves as source of food. The present study aimed to evaluate the nutraceuticals content and topical anti-inflammatory effect of hydro-methanol twig extract of Turraea vogelii (METV). Method: METV was obtained using cold maceration with water and methanol in ratio 30:70. The concentration of vitamins A, C and E, total phenolic and total flavonoid contents were evaluated by UV spectrophotometric method. Phenol and xylene-induced ear edema was used to evaluate the topical anti-inflammatory effect in mice. Results: The concentration of vitamins A, C and E was found to be 0.113, 9.303, and 0.020 mg in100 g of dried plant materials, respectively. Total phenolic and flavonoid contents were 0.281 mg/g gallic acid equivalent and 0.112 mg/g quercetin equivalent, respectively. Topical application of METV at a dose of 25 and 50 mg/ear in xylene-induced ear edema produced significant inhibition (P<0.05) of 33 and 54% while in phenol-induced ear edema was significantly (P< 0.05) reduced by 44% and 34%. Dexamethasone (0.1mg/ear) produced an inhibition of 83% and 57% in phenol-induced ear edema. Conclusion: Results from this study demonstrated that Turraea vogelii twigs contain flavonoids and phenolic compounds, which may be responsible for the topical anti-inflammatory effect of the plant extract. Keywords: Anti-Inflammatory Effect, Dexamethasone, Phenol, Topical, Turraea Vogelii Extract, Xylene
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    Evaluation of anti nociceptive and anti inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth
    (The Faculty of Pharmacy, University of Karachi, 2019-02) Ayanniyi, Rashidat Oluwafunke; Ojuade, Fatimoh Idowu; Olumoh-Abdul, Hidayah; Salawu, Kayode Muritala; Olufadi-Ahmed, , Haishat; Adebisi-jose, Gbemisola Olusayo
    Abstract : The leaf extract of Turraea vogelii Hook. f. ex. Benth . is used in ethnomedicine for the management of pain and inflammation. Anti nociceptive activity was determined using acetic acid induced mouse writhing model. The anti inflammatory activity was investigated using in vitro bovine serum albumin (BSA) denat uration assay and BSA induced hind paw edema in rats. The extract (125 500 mg/kg) administered via the oral route produced a significant ( p <0.005) inhibition of acetic acid induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and dicl ofenac (1 0 mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10 6 1.0 µg /mL) inhibited protein denaturation with IC 50 values of ( 1.06 × 10 3 µg/mL and 2.58 × 10 3 µg/mL) for extract and diclofenac respectively. Furthermore, the leaf extract (62. 5 mg/kg) significantly (p<0.05) inhibited BSA induced paw edema in rats. The methanol leaf extract of T. vogelii has anti nociceptive and anti inflammatory activities. These findings justify the use of the plant in traditional medicine for the management o f pain and inflammation.
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    Evaluation of anti nociceptive and anti inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth
    (Pakistan Journal of Pharmaceutical Sciences, 2019-01) Ayanniyi, Rashidat; Ojuade, Fatimoh; Olumoh-Abdul, Hidayah; Salawu, Kayode; Olufadi-Ahmed, Haishat; Adebisi-jose, Gbemisola
    Abstract : The leaf extract of Turraea vogelii Hook. f. ex. Benth . is used in ethnomedicine for the management of pain and inflammation. Anti nociceptive activity was determined using acetic acid induced mouse writhing model. The anti inflammatory activity was investigated using in vitro bovine serum albumin (BSA) denat uration assay and BSA induced hind paw edema in rats. The extract (125 500 mg/kg) administered via the oral route produced a significant ( p <0.005) inhibition of acetic acid induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and dicl ofenac (1 0 mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10 6 1.0 µg /mL) inhibited protein denaturation with IC 50 values of ( 1.06 × 10 3 µg/mL and 2.58 × 10 3 µg/mL) for extract and diclofenac respectively. Furthermore, the leaf extract (62. 5 mg/kg) significantly (p<0.05) inhibited BSA induced paw edema in rats. The methanol leaf extract of T. vogelii has anti nociceptive and anti inflammatory activities. These findings justify the use of the plant in traditional medicine for the management o f pain and inflammation.
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    Evaluation of anti nociceptive and anti inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth
    (Pakistan Journal of Pharmaceutical Sciences, 2019-01) Olufadi-Ahmed, Haishat Yetunde; Ayanniyi, Rashidat Oluwafunke; Ojuade, Fatimoh Ojuade; Olumoh-Abdul, Hidayah; Salawu, Kayode Muritala; Adebisi-Jose, Gbemisola
    The leaf extract of Turraea vogelii Hook. f. ex. Benth . is used in ethnomedicine for the management of pain and inflammation. Anti nociceptive activity was determined using acetic acid induced mouse writhing model. The anti inflammatory activity was investigated using in vitro bovine serum albumin (BSA) denat uration assay and BSA induced hind paw edema in rats. The extract (125 500 mg/kg) administered via the oral route produced a significant ( p <0.005) inhibition of acetic acid induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and dicl ofenac (1 0 mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10 6 1.0 µg /mL) inhibited protein denaturation with IC 50 values of ( 1.06 × 10 3 µg/mL and 2.58 × 10 3 µg/mL) for extract and diclofenac respectively. Furthermore, the leaf extract (62. 5 mg/kg) significantly (p<0.05) inhibited BSA induced paw edema in rats. The methanol leaf extract of T. vogelii has anti nociceptive and anti inflammatory activities. These findings justify the use of the plant in traditional medicine for the management o f pain and inflammation.
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    Heavy metal content of commonly consumed herbal bitters in Ilorin, Nigeria
    (West African Postgraduate College of Pharmacy, 2017) Ayanniyi, Rashidat Oluwafunke; Folamin, Samson; Olumoh-Abdul, Hidayah; Atunwa, Soliu; Oreagba, Ibrahim
    Background: The use of herbal medicines has increased in recent years and has gained much attention in the health sectors, scientific community and the public alike. The safety and quality of these products become questionable even when the efficacy and potency may be guaranteed. Objective: The presence of heavy metals was determined. Methods: Two batches of five herbal bitters were purchased from different parts of Ilorin. Samples were prepared from these batches and analyzed for the presence of Cadmium (Cd), Iron (Fe) and Lead (Pb) using Atomic Absorption Spectrophotometer. Their concentrations were compared with WHO permissible limits. The variations in the concentration of Cd, Fe, and Pb in the two batches of samples were also determined at P < 0.05. Results: The value of Cd ranged from 0.003-0.3mg/L, Pb 0.000-0.067mg/L and Fe 0.083-0.27mg/L. This study revealed that majority of the samples contained Cd and Pb in concentrations significantly lower than the permissible limits. However, the two batches of herbal bitters contained Fe with concentrations significantly higher than the official permissible limit of 0.1mg/L. Conclusion: The results obtained from this study showed that Iron was present in all the samples with some concentrations significantly higher than the WHO permissible limit. Lead and cadmium were present in some of the samples with concentrations below the WHO permissible limit.
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    The Protective Effect of Croton zambesicus against Carbon Tetrachloride-Induced Renal Toxicity in Rats
    (2019) Ayanniyi, Rashidat Oluwafunke; Olumoh-Abdul, Hidayah; Ojuade, Fatimoh; Abdullahi, Abdulrasheed; Anafi, Sherifat
    Background: The leaf extract of Croton zambesicus (CZ) is used in traditional medicine for the management of various conditions including kidney disease. The purpose of this study was to determine the protective effects of leaf extract of CZ on rat kidney toxicity induced by carbon tetrachloride. Method: Male albino rats were divided into 6 groups of 5 rats and treated for 5 days with aqueous extract (200-400 mg/kg) and n-butanol fraction (20-40 mg/kg) of CZ. Carbon tetrachloride (2 ml/kg of 40% in olive oil) was administered subcutaneously for 3 days and the rats were treated with the extract and fraction for 3 days. Animals were euthanized on day 8 with intraperitoneal injection of ketamine (60 mg/kg) and xylazine (7.5 mg/kg). Blood sample was collected for the analysis of serum electrolytes, urea and creatinine. Kidney tissue was harvested to determine the antioxidant enzyme activity. Results: Carbon tetrachloride produced increased serum sodium ion, chloride ion, urea and creatinine with decreased superoxide, catalase, glutathione, oxidized glutathione and an increase in malondialdehyde concentration. Treatment of rats with the aqueous leaf extract and n-butanol fraction attenuated the toxic effects of carbon tetrachloride on kidney with a significant decline in serum electrolytes, urea, creatinine and a significant increase in the concentration of antioxidant enzymes. Conclusion: Results from this study revealed that the aqueous leaf extract and n-butanol fraction of CZ had protective effect against carbon tetrachloride-induced renal toxicity in rats, thus justifying the consideration of this plant for the management of kidney disease.