Evaluation of anti nociceptive and anti inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth
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Date
2019-01
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Publisher
Pakistan Journal of Pharmaceutical Sciences
Abstract
The leaf extract of Turraea vogelii Hook. f. ex. Benth . is used in ethnomedicine for the management of pain
and inflammation. Anti nociceptive activity was determined using acetic acid induced mouse writhing model. The anti
inflammatory activity was investigated using in vitro bovine serum albumin (BSA) denat uration assay and BSA induced
hind paw edema in rats. The extract (125 500 mg/kg) administered via the oral route produced a significant ( p <0.005)
inhibition of acetic acid induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and dicl ofenac (1 0
mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10 6 1.0 µg /mL) inhibited protein denaturation with
IC 50 values of ( 1.06 × 10 3 µg/mL and 2.58 × 10 3 µg/mL) for extract and diclofenac respectively. Furthermore, the leaf
extract (62. 5 mg/kg) significantly (p<0.05) inhibited BSA induced paw edema in rats. The methanol leaf extract of T.
vogelii has anti nociceptive and anti inflammatory activities. These findings justify the use of the plant in traditional
medicine for the management o f pain and inflammation.
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Keywords
anti-nociceptive, anti-inflammatory, acetic acid, bovine serum albumin,, Turraea vogelii