Evaluation of anti nociceptive and anti inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benth

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dc.contributor.authorOlufadi-Ahmed, Haishat Yetunde
dc.contributor.authorAyanniyi, Rashidat Oluwafunke
dc.contributor.authorOjuade, Fatimoh Ojuade
dc.contributor.authorOlumoh-Abdul, Hidayah
dc.contributor.authorSalawu, Kayode Muritala
dc.contributor.authorAdebisi-Jose, Gbemisola
dc.date.accessioned2021-05-20T12:18:36Z
dc.date.available2021-05-20T12:18:36Z
dc.date.issued2019-01
dc.description.abstractThe leaf extract of Turraea vogelii Hook. f. ex. Benth . is used in ethnomedicine for the management of pain and inflammation. Anti nociceptive activity was determined using acetic acid induced mouse writhing model. The anti inflammatory activity was investigated using in vitro bovine serum albumin (BSA) denat uration assay and BSA induced hind paw edema in rats. The extract (125 500 mg/kg) administered via the oral route produced a significant ( p <0.005) inhibition of acetic acid induced writhes. The percent inhibition of writhes for extract (500 mg/kg) and dicl ofenac (1 0 mg/kg) was 53.3 and 59.5% respectively. The methanol extract (10 6 1.0 µg /mL) inhibited protein denaturation with IC 50 values of ( 1.06 × 10 3 µg/mL and 2.58 × 10 3 µg/mL) for extract and diclofenac respectively. Furthermore, the leaf extract (62. 5 mg/kg) significantly (p<0.05) inhibited BSA induced paw edema in rats. The methanol leaf extract of T. vogelii has anti nociceptive and anti inflammatory activities. These findings justify the use of the plant in traditional medicine for the management o f pain and inflammation.en_US
dc.identifier.urihttps://uilspace.unilorin.edu.ng/handle/20.500.12484/5242
dc.language.isoenen_US
dc.publisherPakistan Journal of Pharmaceutical Sciencesen_US
dc.subjectanti-nociceptiveen_US
dc.subjectanti-inflammatoryen_US
dc.subjectacetic aciden_US
dc.subjectbovine serum albumin,en_US
dc.subjectTurraea vogeliien_US
dc.titleEvaluation of anti nociceptive and anti inflammatory activities of leaf extract of Turraea vogelli Hook. f. ex. Benthen_US
dc.typeArticleen_US

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