Browsing by Author "Odewabi, A. O."

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    Spondias mombin promotes gastric mucosa and lipid profile status in gastric ulceration
    (Brazilian Society of Anatomy and Pan-American Association of Anatomy, 2014-08-10) Akinlolu, A. A.; Ghazali, K. O.; Ameen, Mubarak; Odewabi, A. O.
    Introduction: Spondias mombin has been reported to possess medicinal properties. Material and Methods: This study evaluated the anti-ulcer properties of Spondias mombin. Rats of Group I received physiological saline only while 40mg/kg/bodyweight of Indomethacin (an ulcerogen) was administered to rats of Groups II – VI. Four hours after administrations of the ulcerogen; rats of Groups III – VI were treated daily with oral administrations of 250, 500 and 1000mg/kg/bodyweight of Spondias mombin bark extract and 40mg/kg/bodyweight of Omeprazole respectively for four days. Rats were euthanized on Days 1 (Group II) and 5 (Groups I and III – VI); stomach and liver samples were removed for evaluations of gastric acidity, histo-pathological and lipid profile status. Results: Analyses of gastric acidity and lipid profile status in the stomach and liver samples of rats of Group II showed statistically significant higher levels (P≤0.05) of gastric acidity, total cholesterol, low density lipoprotein-cholesterol and triglycerides but lower high density lipoprotein-cholesterol levels (P≤0.05) when compared to rats of Groups I, and III – VI. Histopathological evaluations showed dose-dependent restorations of stomach and liver histology to pre-ulceration states in rats of Groups III – VI. Conclusions: This study concluded that Spondias mombin administrations promoted histo-pathological restorations of the stomach and liver; and lipid profile status of male wistar rats in Indomethacin – induced gastric ulceration.