Browsing by Author "Noah Adavize Omeiza"

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    Melatonin ameliorates ketoconazole-induced increase in thyroid function
    (Rwanda Journal of Medicine and Health Sciences, 2020-03) Abdullateef Isiaka Alagbonsi,; Luqman Aribidesi Olayaki; Abdulrahim Halimat Amin; Mariam Titilayo Suleiman; Israel Bojuwade; Noah Adavize Omeiza; Sheu Oluwadare Sulaiman
    The antithyroid effect of ketoconazole has been reported. The secretion and action of melatonin in the thyroid gland are also known. However, the possible effect of melatonin on ketoconazole-induced antithyroid effect is unknown. Objective We sought to investigate the modulatory effect of ketoconazole and/or melatonin on thyroid function in female rats. Methods Groups 1-4 of female rats respectively underwent 14-day treatment with normal saline, 25 mg/kg ketoconazole, 4 mg/kg melatonin and 10 mg/kg melatonin. Groups 5 and 6 both received 14-day treatment with ketoconazole and were respectively treated with 4 mg/kg melatonin and 10 mg/kg melatonin simultaneously. Groups 7 and 8 respectively underwent 14-day pretreatment with 4 mg/kg melatonin and 10 mg/kg melatonin, followed by 14-day administration of ketoconazole to both groups. Groups 9 and 10 were both treated with ketoconazole for 14 days, followed by respective 14-day administration of 4 mg/kg melatonin and 10 mg/kg melatonin. Results TSH, T3, T4, and iodine concentrations were increased by separate administration of ketoconazole and either dose of melatonin when compared to control. However, pre-treatment or post-treatment of ketoconazole- treated rats with melatonin abolished the ketoconazole-induced increase in TSH, T3, T4, and iodine while co-administration of ketoconazole with melatonin caused no improvement in the ketoconazole-induced increase in TSH, T3, and T4 except iodine concentration. Conclusion Ketoconazole increased thyroid function, which was ameliorated by pre- or post-treatment with melatonin, possibly via modulation of the iodination process.
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    Oxidative Stress and Hepatotoxic Effects of Levonorgestrel Treatment in Female Wistar Rats
    (Society for Experimental Biology of Nigeria, 2018-10) Abdulrahim Amin Halimat; John Olabode Fatoki; Emmanuel Bukoye Oyewo; AbdulrazaqBidemi Nafiu; Noah Adavize Omeiza; Adeniran Sanmi Adekunle
    Oral Levonorgestrel (LNG) is an emergency contraceptive pills, used in the prevention of unwanted pregnancy and it is effective when taken within first 72 hours of unprotected sexual intercourse. In order to evaluate its toxicological potential, female Wistar rats (140 ± 20 g; n=15) were exposed to LNG at varying doses (0.004 mg/kg b.w) once per week, (0.004 mg/kg b.w) or (0.008 mg/kg b.w) 3 times a week at 48 hours interval each for 6 weeks. Control rats (n=5) were exposed to 0.2 ml/kg b.w physiological saline three times per week at 48 hours intervals for the same period. Blood and tissue supernatants were collected for biochemical assays. The result showed significant (p<0.05) increase in cardiac phospholipids concentration in a dose-dependent manner but at variance in the kidney. Meanwhile, MDA concentration was at variance with no significant different along with reduced GSH values. Serum ALT was significantly (p < 0.05) decreased with LNG 0.004 mg/kg/week when compared with control; however, ALT and AST activities were significantly (p < 0.05) amplified in LNG 0.004 mg/kg/3ce/week and LNG 0.008 mg/kg/3ce/week when compared with LNG 0.004 mg/kg/week. Serum total cholesterol significantly increased with LNG 0.004 mg/kg /week when compared with control while serum triglyceride significantly decreased with LNG 0.008 mg/kg/3ce/week when compared with LNG 0.004 mg/kg /week. These findings indicate that LNG evoked cellular injury without significant peroxidation. It exhibited some metabolic changes with adverse effect. Therefore, its availability should be restricted by prescription and administer as prescribed.