Browsing by Author "Liadi, M.T.,"
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Item Effect of Chronic Administration of Caffeine on Renal Function in Male Wistar Rats(Society for the Conservation of Phytofuels and Sciences., 2022) Ayinde, T.O.,; Ojulari, L.S.,; Afodun, A.M.,; Balogun, M.E.,; Faramade, A.A.,; Raji, A.O.,; Liadi, M.T.,; Belewu, M.A.Caffeine is one of the most widely consumed of all beverages in the World that is capable of stimulating the nervous system, producing alertness of short duration without much regards to organ affectations. Twenty-one (21) male Wistar rats were randomly divided into three (3) groups of 7 rats each as follows: Group I was the control and was given 0.5 ml of NaCl, Groups II and III were administered 0.38 mg/kg and 1.14 mg/kg of caffeine respectively for 14 days. Assessment of renal function was evaluated by collection of urine and blood samples for urinalysis and electrolytes, urea, and creatinine analysis respectively. Urinalysis result precisely showed that protein was positive (+) with a pH of 5.5 in the control group. The LD animals revealed bilirubin (2+), protein (+) with a pH of 5.0. The HD group showed bilirubin (2+), protein (3+) with a pH of 3.5. There was significant (p<0.05) increase in serum urea and creatinine of LD and HD. The serum sodium level was significantly (p<0.05) reduced in LD, while serum potassium level was significantly (p<0.05) increased in the HD group. Chronic consumption of caffeine should be with moderation and at a very lower dose to prevent gradual untoward effects on functions of the kidneys, especially in an already compromised renal status.Item Effect of Chronic Administration of Caffeine on Renal Function in Male Wistar Rats.(Society for the Conservation of Phytofuels and Sciences., 2022) Ayinde, T.O.,; Ojulari, L.S.,; Afodun, A.M.,; Balogun, M.E.,; Faramade, A.A.,; Raji, A.O.,; Liadi, M.T.,; Belewu, M.A.Caffeine is one of the most widely consumed of all beverages in the World that is capable of stimulating the nervous system, producing alertness of short duration without much regards to organ affectations. Twenty-one (21) male Wistar rats were randomly divided into three (3) groups of 7 rats each as follows: Group I was the control and was given 0.5 ml of NaCl, Groups II and III were administered 0.38 mg/kg and 1.14 mg/kg of caffeine respectively for 14 days. Assessment of renal function was evaluated by collection of urine and blood samples for urinalysis and electrolytes, urea, and creatinine analysis respectively. Urinalysis result precisely showed that protein was positive (+) with a pH of 5.5 in the control group. The LD animals revealed bilirubin (2+), protein (+) with a pH of 5.0. The HD group showed bilirubin (2+), protein (3+) with a pH of 3.5. There was significant (p<0.05) increase in serum urea and creatinine of LD and HD. The serum sodium level was significantly (p<0.05) reduced in LD, while serum potassium level was significantly (p<0.05) increased in the HD group. Chronic consumption of caffeine should be with moderation and at a very lower dose to prevent gradual untoward effects on functions of the kidneys, especially in an already compromised renal status.Item Effect of jatropha curcas seed aqueous extract on quality of semen and reproductive hormones in male Wistar rats(Society of Basic and Applied Physiology, 2022) Ayinde, T.O.,; Abubakar, H.O.,; Ojulari, L.S.,; Balogun, M.E.,; Liadi, M.T.,; Olayaki, L.A.,; Belewu, M.A.,; Afodun, A.MBackground: Jatropha curcas is gaining popularity in recent times due to its medicinal value but with less regards to its adverse health effect especially as it concerns male infertility. The current study was aimed at investigating the effect of Jatropha curcas seed extract on quality of semen and reproductive hormones in male Wistar rats. Methodology: Twenty-four male Wistar rats were randomly divided into four groups of six rats each. Group I served as control and was given 0.9% normal saline, while groups II, III and IV were administered 100, 200 and 400mg/kg of the extracts respectively for 60 days. The rats were then euthanised and blood samples collected via cardiac puncture for testosterone, LH and FSH assay; and semen collected for seminal fluid analysis. Results: There was significant (p<0.05) decrease in sperm count, significant (p<0.05) increase in total sperm abnormality, and significant (p<0.05) increase in sperm motility only at high dose when compared with the control. There was also significant (p<0.05) reduction in testosterone and FSH, while LH showed significant (p<0.05) increase. Conclusion: Jatropha curcas seed extract severed sperm quality with affectation of male reproductive hormones. Thus, male desirous of having babies should exercise caution in its patronage.