Browsing by Author "Lawal, A."
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Item Artemether- Lumefantrine Mixed Ligand Complexes: Synthesis and In vitro Antiplasmodial activity Studies(Published by Faculty of Natural Sciences, Al- Hikmah University, Ilorin, Nigeria, 2018-12-25) Rajee, A. O.; Babamale, H. F.; Lawal, M.; Ayinla, S. O.; Lawal, A.; Obaleye, J. A.Malaria is one of the main causes of mortality and morbidity in the world, endangering billions and affecting millions of people each year. Resistance to common antimalarial drugs has proven to be a challenging problem in malaria control. In an attempt to develop efficacious compounds against sensitive and multidrug resistant falciparum malaria, four new complexes of mixed ligands (artemether and lumefantrine) were synthesized using template method. Their antiplasmodial activity potential was evaluated and compared with chloroquine and the parent ligands. The compounds were active against the tested parasite strains. The presence of the metal ions significantly improved the antiplasmodial action against the drug-resistant parasite strains when compared to chloroquine. Additionally, their biological activity was assessed using several in vitro assays. Biological and physical properties were correlated to the antimalarial activity.Item Characterization and Treatment of Spent Deposited Sludge of Transformer Oil (DSTO) by acid leaching and solvent extraction(Institute of Mining and Metallurgy, Australia in collaboration with Taylor and Francis, United Kingdom, 2017-09-18) Baba, A, A.; Ayodele, J. S.; Ameen, O. M.; Jimoh, A.; Johnson, U.; Jimoh, B. A.; Lawal, A.The characterisation of spent transformer oil to determine its fitness for re-refining as well as the recovery of metals by hydrometallurgical treatment in chloride medium has been investigated. The leaching experiments on the spent material showed that its dissolution increases with leachant concentration performed at 75°C. Leaching studies showed that at optimal conditions, the dissolution reached 93% by 1.0 mol L−1 HCl solution within 120 min at 75°C. The solvent extraction of copper by bis(2,2,4-trimethylpentyl) phosphinic acid (CYANEX®272) in kerosene from a pregnant solution of aqueous spent deposited sludge of transformer oil containing 1243.4 mg L−1 Cu++, 389.2 mg L−1 Fe++/+++, 110.7 mg L−1 Ca++ and 235 mg L−1 Al+++ was studied. The results for the solvent extraction give an extraction efficiency of 91.77% total copper acquired via 0.2 mol L−1 CYANEX®272 in kerosene at 27±2°C within 25 min at pH 4.0. A 0.1 mol L−1 HCl solution was found to be sufficient for the stripping of about 94.77% copper from the loaded organic phase. The Fourier transform–infrared spectroscopic analysis of the loaded organic phase supports the stripping experiment as there was no Cu metal ion present in the separated organic phase.Item Chelation, Characterization and Antimicrobial screening of Mixed Isoniazid - Vitamin C complexes(Faculty of Natural Sciences, Al- Hikmah University, Ilorin, Nigeria, 2017-05-04) Bamigboye, M. O.; Obaleye, J. A.; Lawal, A.; Babamale, H. F.; Ajibola, A. A.; Adimula, V. O.; Lawal, M.In this study, mixed Zn(II), Cu(II), Co(II) complexes of Isoniazid and vitamin C were synthesized and characterized by melting point, conductivity measurement, Fourier Transform Infra-red (FT-IR), Atomic Absorption Spectroscopy and elemental analyses. The bonding nature of the mixed parent ligands and the structure of the complexes were based on analytical and spectroscopic techniques. The complexes were proposed to have the formula [M1L1L2(Cl2)], [M2L1L2(SO4)], [M3L1L2(Cl2)] where M1 = Zn(II), M2 = Cu(II), M3= Co (II) L1= Isoniazid and L2 = Vitamin C. The infra-red data relate to the results of the most informative and indicative region. The result of spectra data confirmed that the two ligands were bidentate in their mode of coordination with the metal ions. The complexes are in octahedral geometry and the molar conductance was found to be non-electrolytic in nature. Antimicrobial test was carried out against four bacterial species namely Bacillus subtilus, Staphylococuss aureus, Escherichia coli and Pseudomonas aeroginosa. All the complexes showed higher antibacterial activity at the same concentration against the microorganisms used compared to the ligandsItem Coordination Polymer Based on Mixed Carboxylate Ligands: Synthesis and Thermal Studies(Faculty of Science, Ankara University, Turkey, 2018-09-10) Adimula, V. O.; Tella, A. C.; Udeaga, I. C.; Durodoye, A. T.; Lawal, A.The synthesis of Co(II), Cu(II), Fe(II) and Zn(II) based coordination compounds using terephthalic acid (BDC), tartaric acid (DHB), and 4hydroxybenzoic acid (4-HBA) as ligands by a solvent-based and solvent-free methods were reported. Thermal studies of the complexes performed in the temperature range of 30 ºC-950 °C showed a 9.406% weight loss observed between 200 ºC-517 ºC for [Co(DHB)(4-HBA)] complex, and a 1.883 % weight loss observed between 80 ºC352.68 ºC for [Cu(DHB)(4-HBA)] complexItem Enrichment of a Nigerian Calcite ore for Hydroxyapatite production(Australian Ceramic Society, 2016-10-20) Baba, A. A.; Womiloju, A. A.; Joda, A.; Lawal, A.; Babamale, H. F.; Alabi, A. G. F.; Adekola, F. A.In this study, Hydroxyapatite (HAp) powders have been prepared from Calcite ore of Nigerian origin using diammonium hydrogen phosphate as the Phosphorus source via hydrothermal method. The HAp powders formed is used to determine the chemical structure and nature of HAp crystals at different reaction temperature and time of operation were characterized by X-ray Fluorescence (XRF), X-ray Diffraction (XRD), Scanning Electron Microscope (SEM) coupled with Energy Dispersive X-ray (EDS) and Fourier Transform Infra-red (FT-IR) techniques. Using a set of experimental conditions, different morphology, crystallinity and stoichiometric ratios were obtained. At optimal conditions (1M (NH4)2HPO4, 850C, 6 hours reaction time), a rectangular, rod-like and layered HAp crystal formed yielded Ca/P molar ratio of 1.66 which is close to the stoichiometric HAp ratio of 1.67 required for biomedical applications.Item Iron(II) ) & Copper(ll) Complexes Bearing 8- quinolinol with amino- acids mixed ligands: Synthesis. Characterization and Antibacterial Investigation(King Saud University, Saudi Arabian, 2014-11-30) Amolegbe, S. A.; Adewuyi, S.; Akinremi, A. C.; Adediji, J. F.; Lawal, A.; Atayese, A. O.; Obaleye, J. A.Item Issa, A(2019-11-22) Lawal, A.; Issa A.; Rajee, A. O.; Mamman, A.; Saadu, H. O.; Bamigboye, M. O.; Babamale, H. F.; Osuniran W.; Busari, H. K.Item Mixed Isonicotinylhydrazide – pyridoxine Metal omplexes: Synthesis, Characterization and Antimicrobial activity(The Library and Publications Committee, University of Ilorin, Ilorin, Nigeria., 2016-05-07) Lawal, M,; Obaleye, J. A.; Lawal, A.; Bamigboye, M. O.; Rajee, A. O.; Babamale, H. F.; Nnabuike, G. G.Some mixed metal complexes of isonicotinylhydrazide – pyridoxine have been synthesised and characterised by physical and spectroscopic studies such as melting point, conductivity measurement, TLC, FT-IR and UV-visible spectroscopy. The antimicrobial activities of the metal complexes were investigated against some clinical isolates of Eschericha Coli, Klebsiella Pneumonia, Pseudomonas aureginosa and Stapylococcus species using the agar well diffusion method. The result of the spectroscopic studies revealed that both isoniazid and pyridoxine behave as neutral bidentate ligands. The Isonicotinylhydrazide ligand coordinated through the carboxyl oxygen and amine nitrogen while pyridoxine coordinated through the oxygen of the hydroxyl group and nitrogen of the pyridine group. The result of antimicrobial activity shows that the metal complexes displayed higher inhibitory activity against the tested organisms than the parent ligandsItem Moringa oleifera and Musa sapientum ameliorated 7,12-Dimethylbenz[a]anthracene-induced upregulations of Ki67 and multidrug resistance 1 genes in rats(Qassim University, 2021-05) Akinlolu, A. A.; Oyewopo, A. O.; Kadir, R. E.; Lawal, A.; Ademiloye, J.; Jubril, A.; Ameen, M. O.; Ebito, G. E.Objectives: Moringa oleifera (MO) and Musa sapientum (MS) are plants of ethnomedicinal importance. We evaluated the effects of MOF6 (extracted from MO leaves) and MSF1 (extracted from MS suckers) on immunomodulations of Ki67 (proliferation biomarker) and multidrug resistance 1 (MDR1) genes in the liver of rats in 7,12-Dimethylbenz[a]anthracene (DMBA)-induced hepatotoxicity and mutagenesis to determine their antiproliferation, anti-drug resistance, and anticancer potentials. Methods: Forty-five adult male rats were randomly divided into nine groups (n = 5). Groups 1 and 2 received physiological saline and 15 mg/kg bodyweight of DMBA, respectively. Groups 3 and 4 received 15 mg/kg bodyweight DMBA and were treated with 15 and 30 mg/kg bodyweight of MOF6, respectively. Group 5 received 15 mg/kg bodyweight DMBA and was treated with 10 mg/kg bodyweight of MSF1. Group 6 received 15 mg/kg bodyweight DMBA and was treated with 3.35 mg/kg bodyweight of doxorubicin and intravenous injection of 0.5 ml/200 g of cisplatin. Groups 7–9 received only 15 and 30 mg/kg bodyweight of MOF6 and 10 mg/kg bodyweight of MSF1, respectively. DMBA, doxorubicin, and extracts doses were administered orally. The duration of our experimental procedure was 8 weeks. Consequently, liver histopathology (hematoxylin and eosin technique) and enzyme-linked immunosorbent assay homogenates’ concentrations of Ki67 and MDR1 were evaluated. Computed data were statistically analyzed (P ≤ 0.05). Results: Results showed normal histoarchitectures of the liver in all groups. Statistical analyses showed significant (P ≤ 0.05) and non-significant decreased concentrations (P ≥ 0.05) of Ki67 and MDR1 in Groups 3–9 compared with Group 2. Therefore, MOF6 and MSF1 ameliorated DMBA-induced hepatotoxicity, abnormal proliferation, and drug resistance. Conclusion: MOF6 and MSF1 possess antiproliferation, anti-drug resistance, and anticancer potentials.Item Preparation, Characterization and Biological Studies of Metal Complexes of Mixed Ligands of Nicotinamide and Metronidazole(Nigerian Society of Biochemistry and Molecular Biology, 2017-10-25) Lawal, A.; Ayanwale, P. A.; Rajee, A. O,; Bamigboye, M. O,; Saadu, H. O.; Lawal, M.; Babamale, H. F.; Nnabuike, G. G.; Yunus Issa, M. T.; Amolegbe, S. A.The Mn2+, Fe2+, Cu2+, Co2+, Zn2+ and Ni2+ complexes of mixed nicotinamide and metronidazole were prepared and characterized using solubility, melting point, conductivity measurement, CHNO (carbon, hydrogen, nitrogen, oxygen) elemental analysis, powder X-ray diffraction and infrared spectroscopy . The results of the physical and spectroscopic data confirm the formation of the complexes. For nicotinamide, coordination of the metal to the ligands occurred through the nitrogen of the pyrimidine group, while for mertonidazole, coordination took place through the nitrogen of the amine group. The antibacterial activity of the complexes was carried out against Staphylococcus aureus, Pseudomonas aureginosa, Klebsiella spp, Escherichia coli and Candida spp. Only Cu(II) mixed complex had high inhibitory activity against all three bacteria species. The results of antifungal activity show that all the complexes have no inhibitory activity against the two fungi species compared with the corresponding ligandsItem Solid- State Synthesis and Characterization of Cu (II) Complexes of 3,4,5- Trihydroxyl Benzoic acid(Faculty of Physical Sciences, University of Ilorin, Ilorin, Nigeria., 2017-11-30) Adimula, V. O.; Tella, A. C.; Lawal, A.; Shalme, N.Copper(II) complexes of 3,4,5-trihydroxybenzoic acid, formulated as [Cu(THB)(CH3COO)2] (1a and 1b), prepared by the solid state mechanochemical method (1a) of grinding Cu(CH3COO)2.H2O and 3,4,5trihydroxybenzoic acid in a mortar using a pestle in the absence of a solvent, and a solvent-based method of stirring in ethanol at room temperature (1b) is herein described. Characterization of the synthesized complexes was done by the methods of FT-IR and UV-Vis spectroscopy, PXRD analysis, elemental analysis, and melting point determination. Data obtained from the analytical and spectroscopic techniques indicated that the synthesized compounds, 1a and 1b, are identical. The Cu(II) ion was observed to coordinate to the ligand via the oxygen atom of two of the hydroxyl groups of the ligand resulting in the synthesized [Cu(THB)(CH3COO)2] complexes having a tetrahedral geometry with the ligand binding in a bidentate manner. The solid state mechanochemical synthesis technique offers a simple, quick and environmentally friendly route towards the preparation of metal complexes at the same time giving quantitative yield compared to the solvent-based method of synthesis.Item Solvent Free Synthesis, Characterization and Antibacterial Studies of Urea and Thiourea Metal Complexes(Faculty of Pure and Applied Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria, 2016-10-25) Lawal, A.; Nnabuike, G. G.; Obaleye, J. A.; Bamigboye, M. O.; Lawal, M.Solvent-based synthesis as well as Liquid Assisted Grinding (LAG) synthesis of urea and thiourea complexes is described for comparison purposes. The resulting complexes of both methods of syntheses were characterized using melting points, conductivity values, spectroscopic data (IR, UV-Visible) and antibacterial activity study. Spectral data of the complexes synthesized by LAG method was found to be similar to those synthesized by conventional synthesis. All the ligands were found to be monodentate and all the complexes exhibited tetrahedral and square-planar geometry. The LAG method was carried out by introducing a few drops of solvent. The method is faster with a better yield compared to solvent- based method. The antimicrobial study of the ligands and the complexes was carried out against Gram-positive (Staphylococus aureus and Bacilius subtilis) and Gram-negative bacteria (Eschericia. coli). The antibacterial activity study of the complexes showed that they possessed higher inhibitory activity than their parent ligands at concentration of 200 μgml-1.Item Some non toxic metal-based drugs for selected prevalent tropical pathogenic diseases(Springer and US National Library of medicine, National Institute of Health, 2016-11-30) Amolegbe, S. A.; Akinremi, C. A.; Adewuyi, S.; Lawal, A.; Bamigboye, M. O.; Obaleye, J. A.Metal coordination of bioorganic compounds from both natural and synthetic products is not only gaining recognition in drug design and medicinal inorganic chemistry research, also they are being considered in the improvement of the bioactivity of drugs. What is done in this paper is a review of recent advances in the study of coordinationdriven drug delivery, i.e., metal-based drugs (MBDs). The role of some late first row transition metal ions namely Fe, Cu and Zn in the biological activities of metallodrugs such as antimalarials and antimicrobials are highlighted. It was revealed that the interaction between these bio-essential transition metal ions and the organic drugs could enhance the diagnostic and therapeutic potentials of such formed drugs. This is because such interactions were proved to have improved the stability, bioavailability and cell delivery functions of the metallodrugs. Emphasizing on the challenge of metal ions toxicity, the researchers concluded on the need for the development of MBDs to combat drug resistant parasites without causing injury to normal cells. This would be of significance in addressing the concern World Health Organisation of ameliorating the increasing mortality rate in developing countries.Item Spin- crossover 3D architecture of Fe(II) bearing triazole ligand(Chemical Society of Nigeria, 2018-01-26) Amolegbe, S, A.; Adewuyi, S.; Akinremi, A. C; Oladoyinbo, F.A.; Lawal, A.; Sobola, A.O.; Obaleye, J. A.; Hayami, S.A new assembled iron (II) complex with triazole derivative, [Fe(pbtrz)6](ClO4)2 : (pbtrz = 4, 4’ - (1, 4 - phenylene)bis - 1, 2, 4 - triazole) was synthesized and well characterized. The ligand showed 3D architectures bridging with iron (II) metal through the N-1 and N-2. The investigation of its magnetic properties has revealed a spin-crossover (SCO) between the low-spin (LS) and the high-spin (HS) states (T1/2 = 242 K) without a thermal hysteresis loop. The spin-crossover regime was also followed by Mössbauer spectroscopy. Furthermore, a photo-induced spin transition otherwise known as light-induced excited spin-state trapping (LIESST- effect) was observed when the complex was illuminated at 5 K.Item Synthesis, Characterization and Antimicrobial activities of some Mixed Ascorbic acid –Nicotinamide Metal Complexes(Faculty of Science, Bayero University Kano. Nigeria, 2015-01-25) Lawal, A.; Amolegbe, S. A.; Rajee, A. O.; Babamale, H. F.; Yunus-Issa, M. T.The present study aimed at synthesizing copper(II) and zinc(II) complexes of mixed ascorbic acid and nicotinamide and physiochemically characterize by solubility test, melting point, conductivity t e s t , i n f r a r e d , e l e c t r o n i c a n d p r o t o n n u c l e a r m a g n e t i c r e s o n a n c e t e c h n i q u e s . T h e r e s u l t o f t h e physiochemical studies indicated 1:1 stoichiometry and were supported by the spectroscopic data. T h e a n t i m i c r o b i a l a c t i v i t i e s o f t h e m i x e d c o m p l e x e s w e r e c a r r i e d o u t a g a i n s t B a c i l l u s s u b t i l i s , Escherichia coli, Staphylococcus aureus, Penicillum , spp Aspergillus flavus and Aspergillus niger. The result of the infrared data showed that ascorbi c acid coordinates through the oxygen of the carbonyl group and that of enolic C-2 hydroxyl grou p, while nicotinamide coordinates through the nitrogen atom of the pyridine ring. The result of t he antimicrobial studies showed that the mixed complexes have higher inhibitory activity than the original ligands against the tested bacteria and fu ngi speciesItem Synthesis, Characterization and Antimicrobial activity of Mixed Transition Metal Complexes of salicylic acid with 1,10 - Phenanthroline(World Bank Assisted National Agricultural Research Project (NARD), Faculty of Science, University of Port-Harcourt, Nigeria, 2017) Lawal, A.; Shodeinde, A. S.; Amolegbe, S. A.; Elaigwu, S. E.; Yunus-Issa, M. T.A new series of Mn(II), Fe(II), Co(II), Cu(II) and Zn(II) mixed ligands-metal complexes derived from salicylic acid (SA) and 1,10-phenanthroline (PHEN) have been synthesized and characterized by spectroscopic studies. The coordination of the two ligands towards central metal ions has been proposed in the light of elemental analysis, IR, UV–vis spectroscopic studies. The results of the physical and spectroscopic data confirmed that the ligands are chelating agents. In 1, 10-phenanthroline, coordination occurred through the two pyridinic nitrogen groups, while in the salicylic acid coordination occurred through the oxygen of the hydroxyl and the carboxylic groups. All the complexes synthesized were of octahedral geometry.Antimicrobial activity of the mixed ligands metal complexes and the free ligands were carried out against the bacterial Escherichia coli, staphylococcus aureus, klebsiella pneumonia, pseudomonas aeruginosa and the fungi candida spp. The mixed ligands metal complexes showed higher activities when compared to the free ligands of salicylic acid but were less active than the free 1,10-phenanthroline ligand. The complexes of Cu (II) showed the highest antimicrobial activity while the Fe(II ) complex showed the least activity against the bacterial and fungi organismsItem Synthesis, Characterization and Biological activity of Metal Complexes Mixed Citric acid and Amodiaquine(Faculty of Science, Bayero University Kano. Nigeria, 2017-05-20) Lawal, A.; Olowude, S.; Bamigboye, M. O.; Sa`ad, H. O.; Nnabuike, G. G.; Yunus-Issa, M. T.; Amolegbe, S. A.A range of d-block transition metals complexes of mixed amodiaquine and citric acid have been synthesized and characterised using microanalytical technique , elemental analysis, FT-IR spectroscopy and magnetic measurement. The results of the analytical and spectroscopic data revealed that both amodiaquine and citric acid acted as bidentate ligands in the ir mode of coordination with the metal ions.The citric acid bound through the carbonyl (C=O) and hydroxyl groups to the metal ions while, amodiaquine coordinated through the nitrogen atom of the amine and oxygen donor atom of hydroxyl group; resulted in structures with octahedral geometry. Percentage composition and magnetic Bohr moment data indicated that all metal complexes were paramagnetic. Molar conductance measurement indicates that the complexes are non-electrolytes in nature. The antimicrobial activity of the ligands and their mixed complexes was carried out against g(+)Pseudomonas aeruginosa, g(+)E. coli, g( +)Klebsiella pneumonia, g(+)Staphylococcus aureus and g(+)Candida using Muller Hinton diffusion method. The citric acid and amodiaquine result showed low or moderate value from (0.6-0.8) for all the metal complexes with the exception of the Cu(II) complex having inhibitory zones ranging from 1-0-1. 3 , 0 . 7 - 0 . 9 at 200 ppm respectively. Moreover, the free ligands were found being less active compared with their mixed complexes.Item Synthesis, Characterization and Biological Studies of Mixed Paracetamol - Ascorbic acid Metal Complexes(World Bank Assisted National Agriculture Research Projects (NAARP), Faculty of Science, University of Port-Harcourt, Nigeria, 2016-09-25) Babamale, H. F.; Lawal, A.; Oloyede, E. A.; Rajee, O. A.Mixed ligand-metal complexes of Paracetamol and Ascorbic acid were synthesized using FeCl2.4H2O, CuCl2.2H2O, NiCl2.6H2O, CoCl2.6H2O and ZnSO4 salts based on two concentrations (3mmol and 5mmol). The complexes were characterized using some physical techniques such as melting point, solubility, conductivity measurement and spectroscopic analyses such as UV-Visible spectroscopy, Atomic absorption spectroscopy, and Infrared spectroscopy. Based on the physical and spectroscopic results, the coordination of the metal was through the phenolic oxygen and carbonyl oxygen in paracetamol while it was through the carbonyl oxygen and C-2 hydroxyl group in ascorbic acid. The complexes were also screened for their antimicrobial activities against some isolates of Enterococcus faecalis, Staphylococcus aureus, Clostridium difficile, Klebsiella sp., Helicobacter pylori