Browsing by Author "Lawal A.Z.,"

Now showing 1 - 7 of 7
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    Antihypertensive and cardioprotective Effects of Ficus Exasperata Leaf Extract In L-NAME-Induced Hypertensive Rats.
    (Faculty of Science, University of Ibadan., 2023) Lawal A.Z.,; Kehinde, B.D.,; Ibrahim, M.,; Adetoyi, M.G.,; Fatunbi, R.O.,; Oyerinde, O.T.,; Balogun, E.,
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    Antihypertensive potential of Azadirachta indica leaf in salt-induced hypertensive albino rats.
    (Anatomical Society of Nigeria., 2025) Lawal A.Z.,; Ibrahim M.,; Oluseyi O.D.,; Olalekan S.O.,; Kareem M.A.,; Olorukooba H.O.,; Oriire O.,; Abdulraheem H.,; David K.B.,; Forunsho K.P.I. &; Jimoh-Abdulgafar H.O
    Hypertension is a condition arising from persistently elevated blood pressure, leading to severe complications, including death. Factors such as high salt consumption and family history predispose individuals to hypertension. Azadirachta indica (AI) has shown potential in reducing high blood pressure, irregular heart rhythms, and abnormal heartbeats. This study aimed to assess the antihypertensive effect of Azadirachta indica methanolic leaf extract (AIMLE) on salt-induced hypertension in albino rats. The study involved 25 healthy male albino rats (150 - 250g), divided into five groups (A-E, n=5). Group A received normal salt feed and water (vehicle), group B received high-salt feed (HSF), group C received HSF and 500 mg/kg AIMLE, group D received HSF and 1000 mg/kg AIMLE, and group E received HSF and 10 mg/kg Nifedipine. Systolic (SBP) and diastolic (DBP) blood pressures were measured using the tail cuff method. Antidiuretic hormone (ADH) and Angiotensin-Converting Enzyme (ACE) levels were analyzed using ELISA methods. Nitric Oxide, Potassium, Bicarbonate, and Sodium were assayed using the colorimetric method. Administration of HSF caused a significant (p <0.05) progressive increase in SBP and DBP after 8 weeks when compared with the normal control. However, treatment with the serial doses of AIMLE resulted in a significant (p <0.05) dose dependent decrease in SBP, DBP and serum nitric oxide concentrations as well as decrease in serum levels of ACE, ADH, potassium, bicarbonate, and sodium ions when compared with untreated HSF group, after 8 weeks. These findings suggest that Azadirachta indica leaf extract may offer a natural remedy for managing hypertension.
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    Biochemical changes in alloxan-induced diabetes in rat liver and kidney dosed artesunate.
    (International Institute of Science and Technology, 2019) Olaniyan, L.W.B.,; Olagoke, E.O.,; Abdulrazak M.A.,; Lawal A.Z.,; Adeogun E.F.,; Adefemi, K.O.,
    Diabetes is a disease marked by elevated blood sugar levels, and the second leading cause of renal diseases and blindness worldwide. Artesunate is an antimalarial drug, that has been reported to have hypoglycemic potential, but to the best of our knowledge, much work has not been done to explore the biochemical and clinical implications of administration of artesunate on a diabetic subject. This study investigates biochemical changes in terms of oxidative status associated with oral administration of artesunate on diabetic animal model. Twenty eight male Wistar rats weighing averagely 200g were divided into four groups of seven rats each, Group Acontrol, B- Diabetes only, C- Artesunate only, D- Diabetes + Artesunate. Diabetes was induced intraperitoneally, at a single dose of Alloxan(160mg/kg body weight(bw). Artesunate was administered orally in aqueous solution at 2.90mg/kg bw on day one, and at 1.45mg/kg bw on the subsequent 7days. Spectrophotometric technique was used for biochemical analysis in serum, kidney and liver homogenates. Aspartate amino transferase (AST) and Alanine amino transferase (ALT) activities as well as Creatinine concentration were significantly (P<0.05) increased in group B compared with control, while group D showed a significant (P<0.05) decrease compared with group B. Total protein concentration was significantly(P<0.05) increased in group B compared with control, while group D showed an insignificant decrease compared with group B. Moreover, Superoxide dismutase(SOD) and Catalase(CAT) activities as well as Reduced glutathione (GSH) concentration were significantly(P<0.05) decreased in group B compared with control, and were restored near to the control level significantly (P<0.05) in group D, compared with group B. Malondialdehyde (MDA) concentration was significantly (P<0.05) increased in group B compared with control, but was reversed significantly (P<0.05) in group D compared with group B. Artesunate ameliorates oxidative stress in diabetic rats liver and kidney, possess hypoglycemic effect, hence antioxidant and hypoglycemic effects of artesunate may be beneficial to diabetic liver and kidney.
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    CRYPTORCHIDISM AND HYPERTHERMIA-INDUCED TESTICULAR INJURY IN ADULT MALE RATS; INTERVENTION OF ALPHA TOCOPHEROL
    (Society for Experimental Biology of Nigeria, 2023) Adunmo G.O.,; Lawal A.Z.,; Oyewopo A.O.,; Oyewopo C.I.,; Stephen D.A.,; Akindehin O.A.,; Adunfe O.O.,; Adeleke O.S.,; Hamzat F.O.,; Ashamu E.A.,
    The objective of this study is to determine the effects of cryptorchidism and hyperthermia on the testicular cytoarchitecture of adult male rats, quality and quantity of semen and the level of oxidative stress in the testes before and after intervention of Alpha-tocopherol (Vitamin E). Twenty-four (24) adult Wistar rats were used for this experiment and they were divided into seven groups (n=4). Experimental cryptorchidism was carried out in some animals while others were subjected to hyperthermia from two sources (hot oven and light bulb) for 28 days; followed by intervention of 100mg/kg alpha-tocopherol for fourteen (14) days. All animals were then euthanized under anaesthesia. The testes were excised and fixed and processed using haematoxylin and eosin technique. Plasma was assayed for glutathione, superoxide dismutase (SOD) and malondialdehyde (MDA). Cryptorchidism and hyperthermia caused in cycto-architectural distortion in the testicular structures of exposed animals and significant reductions in caudal epididymal sperm count and motility, morphology and life and death ratio. Plasma SOD and GLU levels also reduced significantly in exposed animals while MDA levels increased significantly, indicating peroxidation of testicular tissue. Alpha-tocopherol due to its anti-oxidative properties impeded lipoperoxidation of the membrane, conserving cell union and increasing the amount of germ cells in the seminiferous epithelium. At doses and durations tested, alpha-tocopherol (αT) reverted to a significant extent the effects of cryptorchidism and hyperthermia by reducing apoptosis in germ cells, promoting cell survival and reducing histological alterations to the seminiferous epithelium.
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    Depressive state assessment of pregnant women attending the antenatal clinic of university of Ilorin teaching hospital (UITH), Ilorin, Kwara State, Nigeria.
    (Anatomical Society of Nigeria., 2025) Jimoh-Abdulgafar H.O.,; Gwadabe S.M.,; Jimoh O.S.,; Bello S.A.,; Onwunali M.N.,; Adeojo A.S.,; Gabriel O.J.,; Bamishe G.A.,; Alabi M.T.,; Afolayan J.A.,; Abubakr M.K.,; Okunnu B.E.,; Isah A.O.,; Lawal A.Z.,; Lawal R.O.,; Ayinla M.T., &; Ojulari L.S.
    Antenatal depression, with a global prevalence of between 15 and 65%, is a clinical condition characterised by persistent sadness, anxiety, and hopelessness during pregnancy. It is a strong predictor of postpartum depression, and it negatively impacts pregnancy outcomes, maternal-child bonding, and child development. Untreated antenatal depression could lead to an increased risk of obstetric complications, inadequate prenatal care, poor maternal nutrition, substance abuse, and in severe cases, maternal suicide. Despite being a significant global public health concern, antenatal depression is often overlooked in developing countries like Nigeria, both in terms of research and treatment. Consequently, only a few studies are focusing on antenatal depression, resulting in a poor understanding of the prevalence of depressive symptoms during pregnancy and their associated risk factors. This study aims to fill the gap in knowledge regarding antenatal depression in the Ilorin population. A cross-sectional study was conducted among over 200 pregnant women attending the antenatal clinic at the University of Ilorin Teaching Hospital, where participants were administered a battery of questionnaires (ANRQ, PHQ-9, and QIDSS-163) after obtaining informed consent. The results were analysed using. The results showed that the level of education (ANRQ, QIDSS-16), number of live births (QIDSS-16), age, and number of children (PHQ-9) have a positive impact on the risk and severity of antenatal depression in pregnant women attending the antenatal clinic at UITH. Age, level of education, number of live births, and number of children are strong predictors of the risk and severity of antenatal depression.
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    Selected liver function indices in Male farmers exposed pesticides.
    (Faculty of Health Sciences, Al-Hikma University., 2023) Lawal A.Z.,; Ibrahim M.,; Mohammed, Z, N,,; Ogunwale, K. A.,; Wasiu, O.G.,; Popoola, A.N.,; Adunmo, G.O.,; Suleiman, I.E.,; Busari, A.O.,; Balogun, M.O.,; Ibironke, E.,; Adekunle, C.,; Adedotun, M.; Nuhu, A.
    Introduction: Exposure to environmental toxins and ensuing liver health outcomes has attracted global attention. This study was aimed at assessing the liver function indices among farmers exposed to pesticides. Methodology: This research was carried out on 130 apparently healthy male participants aged 18 years and above. The participants were randomly selected for this comparative cross-sectional study. The participants were further divided into two groups; the Pesticide-exposed group and the control group (non-exposed). Demographic characteristics of the participants were obtained by standard methods. Five milliliters of fasting blood samples were collected from each participant after an overnight fast (8 to 12 hours). A portion of the blood sample was dispensed into plain tubes for the estimation of serum Aspartate aminotransferase, alanine aminotransferase, albumin, and total protein. Statistical Package for Social Science (SPSS) 25.0 software was used for statistical analysis. Results: The results from this study suggest that exposure to pesticides may have adverse effects on the liver as evidenced in the observed significant (p ≥ 0.05) increase in serum AST, ALT, and decreased Albumin and Total protein values in the pesticide-exposed group when compared with the normal control.
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    THERAPEUTIC EFFECT OF QUERCETIN ON THE HYPOTHALAMUS OF STZ-NICOTINAMIDE INDUCED DIABETIC RATS
    (Society for Experimental Biology of Nigeria, 2023) Lawal A.Z.,; Adunmo G.O.,; Oyewopo A.O.,; Oyewopo C.I.,; Stephen D.A.,; Akindehin O.A.,; Adunfe O.O.,; Adeleke O.S.,; Hamzat F.O.,; Ashamu E.A.
    Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia and disturbances in sugar, fat, and protein metabolism. The aim of this study was to investigate the therapeutic effect of quercetin on the hypothalamus in adult male Wistar rats with STZ-nicotinamide-induced diabetes. Forty rats were divided into eight groups, each receiving different treatments. The control group received a standard diet, while other groups were administered various doses of quercetin alone, diabetes induction agents alone, or a combination of quercetin and diabetes induction agents. Treatments were administered orally for eight weeks. Results revealed significant differences in body weight among the groups, with diabetic rats showing a decrease compared to the control group. However, rats treated with quercetin or metformin exhibited a significant increase in body weight compared to the diabetic control group. Additionally, diabetes induction significantly decreased plasma insulin, plasma testosterone, follicle-stimulating hormone (FSH), and luteinizing hormone levels, while quercetin treatment led to significant increases in these hormone levels. Histological examination of the hypothalamus showed notable findings. Control group rats displayed normal histomorphological features, while diabetic control rats exhibited swollen and distorted hypothalamic cells with cellular apoptosis. Interestingly, rats treated with quercetin showed a reduction in apoptotic cells, indicating a protective effect on hypothalamic cells. In conclusion, our findings suggest that quercetin possesses potential therapeutic properties in ameliorating the detrimental effects of STZ-nicotinamide-induced diabetes on the hypothalamus in adult male Wistar rats.