Browsing by Author "Kola-Mustapha, A.T."
Now showing 1 - 16 of 16
Results Per Page
Sort Options
Item A purview of herbal therapies deployed in the traditional management of sickle cell disease in Kwara Nigeria.(Pharmaceutical Journal of Kenya, 2023) Kola-Mustapha, A.T.; Ghazali, Y.O.; Ayotunde, H.T.; Khalid-Salako, F.A.Item Antifugal Screening of Ceiba petandra and Lannea Kerstingii Stem Bark Extract Cream Formulations(The Journal of Pharceutical Science and Practice, 2014) Kola-Mustapha, A.T.; Aremu, O.I.; Njiga, N.S.; Ayotunde, H.T.Item Arctium lappa root extract based emulgels attenuates inducible cytokines and prostaglandins formation: Potential in the management of chronic inflammatory disorders.(Scientific African, 2023) Kola-Mustapha, A.T.; Abdulrahman, M.O.; Ishola, I.O.Item Design, Formulation and evaluation of Chasmanthera dependens Hochst and Chenopodium ambrosioides Linn based gel for its analgesic and anti-inflammatory activities.(Heliyon, 2021) Kola-Mustapha, A.T.; Yohanna, K.A.,; Ghazali, Y.O.; Ayotunde, H.T.Item Evaluation and formulation of the methanol extract and oil of Nigella sativa Linn into suppositories with potentials in the management of vaginal candidiasis.(Current Traditional Medicine, 2021) Kola-Mustapha, A.T.; Bamigboye, F.A.; Olufadi-Ahmed, H.Y.; Ayotunde, H.T.; Ghazali, Y.OItem Evaluation of Terminalia macroptera (Combretaceae) Guill. & Perr stem bark extract incorporated into an emulgel for the potential management of rheumatoid arthritis(Scientific African, 2023) Kola-Mustapha, A.T.; Suleiman, T.; Rofiat, I.A.; Omowunmi, A.O.; Ishola, I.O.; Ghazali, Y.O.; Usman, S.OItem An Evaluation of the Impact of Zinc and Copper Metal-Organic Frameworks (MOFs) on the Drug Release Profiles of Piroxicam(Journal of Pharmaceutical Research, Development and Practice, 2020-05) Kola-Mustapha, A.T.; Ayuba, A.A.; Amali, M.O.; Atunwa, S.A.; Ishola, F.; Tella, A.C.Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) poorly soluble in an aqueous medium with a slow and gradual dissolution in biological fluids resulting in sub-optimal efficacy in patients. In recent times, Metal-Organic Frameworks (MOFs), a new class of highly tenable hybrid porous materials with unique properties have been explored for usage as drug carriers and other biomedical applications. This study is aimed at studying the solubility, in vitro release profile and kinetics of piroxicam loaded Zinc and Copper Metal-Organic Frameworks. Piroxicam was loaded on Zinc and Copper MOFs and tested for its solubility, dissolution and drug release profile. The mechanisms of the release pattern of the drug from Zinc and Copper MOFs were analysed using kinetic models. At the end of the study, Piroxicam-loaded Zn MOFs had solubility of 161.34 ± 0.63 μg/mL, while that of Cu MOFs and pure piroxicam had solubility of 154.31 ± 1.27 μg/mL and 134.86 ± 0.48 μg/mL respectively. Within a period of 24 hours, Piroxicam had the highest release from Zn MOFs; with a drug release in the range of 43.70 to 99.10%. Piroxicam was released from the loaded Cu MOFs in the range of 41.20 to 78.3% while the release of pure Piroxicam was in the range of 37.50 to 49.0%. Mechanism of piroxicam release was by Fickian diffusion. Piroxicam was successfully loaded on Zinc and Copper MOFs. Zn MOFs demonstrated a better solubility and dissolution profile as compared to Cu MOFs. These study shows the drug delivery potentials of the Zinc and Copper MOFs in improving the solubility and drug release of piroxicam. ___________________________________________________________________________ KEYWORDS: piroxicam, solubility, zinc, copper, MOFs, drug release.Item Formulation of Entandrophragma utile into an herbal emulgel for the management of inflammation.(Gels, 2023-12) Kola-Mustapha, A.T.; Ibraheem H.F.; Suleiman T.; Ishola I.O.; Usman S.O.; Ghazali Y.O.Item Herbal emulgels incorporated with Cola millenii K. Schum stem bark ethanol extract potentially for the management of rheumatoid arthritis in-vitro(Phytomedicine Plus, 2021) Kola-Mustapha, A.T.; Khalid-Salako, F.AItem Isolation, characterization and anti-inflammatory activity of compounds from the Vernonia amygdalina.(Heliyon (Elsevier (Cell Press), Amsterdam, The Netherlands. ), 2024-04) Atolani, O.; Usman, M.A.; Adejumo, J.O.; Ayeni, A.E.; Ibukun, O.J.; Kola-Mustapha, A.T.; Njinga, N.S.; Quadri, L.A.; Ajani, E.O.; Amusa, T.O.; Bakare-Odunola, M.T.; Oladiji, A.T.; Alqahtani, A.; Mohamed, A.; Kambizi, L.Item Polypharmacology of specific medicinal plant metabolites against SARS CoV-2 targets: Molecular dynamics evaluation of NSP9 RNA binding protein.(Journal of Biomolecular Structure and Dynamics,, 2021) Bandyopadhyay, S.; Abiodun, O.A.; Ogboo, B.C,; Kola-Mustapha, A.T.; Attah, E.I.; Edemhanria, L.; Kumari A.; Jaganathan, R.; Adelakun, N.S.Item Preliminary study on the anti-bacterial activity of 2 cultivars of Acalypha wilkesiana on bacterial isolates of clinical significance(Pharmaceutical Society of Nigeria, 2022) Aboh, M.I.; Katibi, O.S.; Salawu, O.A.; Olatunji, K.T.; Fatokun, O.T.; Kola-Mustapha, A.T.; Oladosu, P.O.Background: Anti-microbial resistance has become a major problem in clinical practice making it necessary to search for newer molecules. Acalypha wilkesiana, is a herb commonly used traditionally in Nigeria to treat gastrointestinal disorders, wounds and skin infections like impetigo. Objectives: To determine the in-vitro anti-bacterial activity of crude extracts of 2 cultivars of Acalypha wilkesiana (Macrophylla & Hoffmanii) Methods: In-vitro antibacterial activity was investigated by agar diffusion and micro-broth dilution techniques. Bacterial isolates tested were Escherichia coli, Methicillin Resistant Staphylococcus aureus, Staphylococcus aureus, Salmonella paratyphi, Pseudomonas aeruginosa and Klebsiella pneumoniae. Results: The ethanol extract of both cultivars were more active than the ethyl acetate and n-hexane extracts having diameter zones of inhibition against all the bacteria tested at a range of 12.00-22.00 mm. The lowest MIC of the crude ethanol extract was seen with E. coli (1000 µg/ml) and S. aureus(1000 µg/ml; 2000 µg/ml) while the most active fractions (R2, R4, G3 and G4) of the crude ethanol extract of both cultivars had greatest activity against MRSAand P. aeruginosa (156 µg/ml). Conclusion: This study shows that Acalypha wilkesiana has good broad spectrum anti-bacterial activity with the potential for development as lead compounds to combat multi-drug resistant organisms like MRSA.Item Proteinease Inhibitory, Membrane Stabilization, Phytochemical and Antioxidant Evaluations of Leaves, Seeds and Calyces of Four Selected Edible Medicinal Plants(Tailoy and Francis, 2017-04-07) Kambizi, L.; Bakare-Odunola, M.T.; Oladiji, A.T.; Kola-Mustapha, A.T.; Amusa, T.O.; Atolani, O.; Njinga, N.S.; Quadri, A.L.The aqueous extracts of the edible parts of four common medicinal plants (Hibiscus sabdariffa, Telfairia occidentalis, Moringa oleifera and Ocimum gratissimum) readily consumed as food or supplements in many African settings are examined for some of their acclaimed pharmacological activities and possible potential associated risks. The classes of phytochemicals present are examined qualitatively and quantitatively, while the antioxidant activities were determined using three assays which include 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azinobis-3-ethylbenzothiazoline- 6-sulfonate (ABTS) and hydrogen peroxide (H2O2) assays. The anti-inflammatory activities were also examined using proteinase inhibitory assays and red blood cell membrane stabilisation assays. Both the antioxidant and anti-inflammatory activities of the plants indicated that the plants have potentials for applications in foods and nutraceuticals that can be used for the management of various ailments and diseases. However, the consumption of H. sabdariffa leaf should be highly regulated as the extract exhibited reduced cell membrane stabilisation activities at increased concentrations.Item The Formulation and Evaluation of Melaleuca alternifolia Cheel and Cymbopogon flexuosus Linn Essential Oils Emulgel for the Treatment of Vulvovaginal Candidiasis.(Gels, 2023-12) Kola-Mustapha, A.T.; Aliu M.H.; Bello R.H,; Adedeji A,; Ghazali Y.O.Item The use of herbal medicines amongst out-patients at the University of Ilorin Teaching Hospital (UITH) Ilorin, Kwara State – Nigeria.(Complementary Therapies in Medicine,, 2019) Ghazali, Y.O.,; Bello, I.; Kola-Mustapha, A.T.Background In Africa, particularly Nigeria, there is an increasing interest in natural product remedies with a basic approach towards nature. This research studies the prevalence of use, pattern of use and awareness of outpatients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria on the use of herbal medicines. Methodology Based on an informed consent, semi-structured questionnaires were used to collect data from a total of 112 outpatients attending different outpatient clinics of the hospital about the use of herbs. This sample size was derived from the Kish formula. Data obtained were analyzed by IBM SPSS Statistics software V23 and inferences made accordingly. Results All (100.00%) of the outpatients were familiar with herbal medicines, 67.86% had used herbal medicines in the past and 25.00% were currently taking herbal medicines as at the time of study. It was also found that 54.35% of the respondents use herbal medicines in no specific dose, 47.83% use the herbs with various additives, and 39.13% take their herbs concurrently with orthodox medicines. A total of 13.73% of the respondents prefer to use herbs when sick and another 35.29% prefer a combination of herbs and orthodox medicines. Conclusions Most of the patient-respondents prefer to include herbal medicines in their therapies. It is concerning that over one-third of the respondents concomitantly use herbal and orthodox medicines, some others use the herbs inappropriately. More efforts should be geared towards ensuring general improved use of herbal medicines.Item Toxicity assessment of sub-acute and sub-chronic oral administration and diuretic potential of aqueous extract of Hibiscus sabdariffa calyces(Heliyon, 2020) Njinga, N.S.; Kola-Mustapha, A.T.; Quadri, A.L.; Atolani, O.; Ayanniyi, R.O.; Buhari, M.O.; Amusa, T.O.; Ajani, E.O.; Folaranmi, O.O.; Bakare-Odunola, M.T.; Kambizi, L.; Oladiji, A.T.; Ebong, P.