Browsing by Author "Jones, Olanrewaju Moody"

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    Heavy Metals, Proximate Analysis and Brine Shrimp Lethality of Vernonia amygdalina and Ocimum gratissimum Growing in Crude Oil-Rich Delta State, Nigeria
    (2021-11-24) Oluwatofunmilayo, Arike Diyaolu; Alfred, F. Attah; Emmanuel, T. Oluwabusola; Jones, Olanrewaju Moody; Marcel, Jaspars; Rainer, Ebel
    Vernonia amygdalina (VA) and Ocimum gratissimum (OG) are among the most frequently consumed vegetables in Kokori and Abraka communities of Delta State, Nigeria. However, the continuous crude oil exploration and spillages in Kokori may threaten their safety for use as food and medicine. Twelve samples of VA and OG obtained from crude oil-rich and crude oil-free communities were comparatively analysed for proximate composition, heavy metals, and cytotoxicity. Data obtained were subjected to various multivariate statistical techniques, including principal component analysis (PCA), biplot, and analysis of variance (ANOVA), to investigate the correlations between the vegetables from the different communities and the effect of crude oil exploration and spill on plant biomass. Results obtained indicate a significant difference (p < 0.05) in the proximate composition of VA and OG and higher heavy metal content for VA from the crude oil-spill Kokori. Two VA collections from Kokori were exceptionally toxic to cellular crustaceans.
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    Hypoglycaemic and Antioxidative Properties of Freeze-Dried Garcinia Kola Seeds in Type 2 Diabetics and Non-Diabetics with Chronic Foot/Leg Ulcer in Ibadan, Nigeria: A case-control clinical study
    (African Journal of Health Sciences, 2021-05) Elizabeth, Bosede Bolajoko; Augustine, Anayochukwu Onyeaghala; Olubayo, Michael Akinosun; Alfred, Francis Attah; Olufemi, Joseph Adewumi; Adefunke, Temiloa Adeoti; Ayodele, Olukayode Iyun; Adesoji, Adedipe Fasanmade; Jones, Olanrewaju Moody; Aye, Aye Khine
    INTRODUCTION The antidiabetic and antioxidative properties of Garcinia kola (GK) seed extracts have been well documented in animal studies; however, data on freeze-dried powder of GK seeds (FDGK) in humans are scarce. This study investigated the effect of 8-weeks supplementation of FDGK on glycaemic control and oxidative stress levels in Type 2 diabetics with or without foot/leg ulcer and compared with nondiabetics with or without chronic foot/leg ulcer in Ibadan, Nigeria. MATERIALS AND METHODS Thirty diabetics with foot/leg ulcer (DFU), 30 diabetics without ulcer (T2DM), 30 non-diabetics with chronic foot/leg ulcer (NDCU) and 30 non-diabetics without ulcer (NDC) were divided into: subgroup-1 (250mgGK); subgroup-2 (500mgGK); subgroup-3 (No-supplementation). Plasma glucose (FPG), glycated haemoglobin-A1c (HbA1c), total plasma peroxides (TPP), total antioxidant status (TAS), oxidative stress index (OSI), antioxidant-micronutrients were determined in fasting blood samples. Wounds were clinically assessed and rated using modified ABDEFS. RESULTS All participants supplemented with 250mgGK or 500mgGK for 8 weeks showed decreases in TPP and OSI with improvement in wound healing, increases in TAS and antioxidant-micronutrients (p<0.05). In addition, significant decreases in FPG were observed in DFU and T2DM supplemented with 250mgGK, and also in NDC supplemented with 500mgGK. In non-supplemented subgroups, increases in TPP and OSI with decreases in TAS and antioxidant-micronutrients (p<0.05) were observed. CONCLUSION Supplementation with Garcinia kola could be used as an adjunct for prevention and treatment of diabetes mellitus complicated with or without foot/leg ulcer RECOMMENDATIONS Caution must be taken when used as prophylactic in non-diabetics to prevent occurrence of hypoglycaemia.