Browsing by Author "Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa"

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    ABO/Rhesus blood group systems are not clinical indicators of male baldness
    (College of Medicine, Ambrose Alli University, Edo, Nigeria, 2017-06) Ayinde, T. O.; Ojulari, L. S.; Sanni, M. A.; Afodun, A. M.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Ayinla, M. T.; Abdulazeez, F. I.; Abdulkareem, S.; Abdulraheem, H. A.; Samotu, K.
    Background: Several disease entities have been linked to the ABO/Rh blood group systems.Baldness or alopecia is the partial or complete lack of hair on the head and/or body. Major advances have been achieved in understanding principal elements of the androgen metabolism involved in the pathogenesis of alopecia, but not much preliminary work has been done in its relationship to blood types. Aim: This study is aimed to determine if there is any association between blood types and male baldness. Methods: 400 male subjects (25-60 years)at Sobi Specialist Hospital Alagbado, Ilorin, kwara State, Nigeria were recruited into the study(200 for control and 200 for baldness).Blood sample was collected from each subject for blood grouping estimation, following the completion of a questionnaire containing information about baldness and haematological profile. Result: The distribution of phenotypic frequencies of ABO group in the control samples were 26.0%, 28.0%, 4.0% and 42.0% for groups A, B, AB and O, respectively, while 92.0% of the subjects were Rh (D) positive and 8.0% Rh(d) negative. And for the baldness, they were 26.0%, 26.0%, 4.0% and 44% for A, B, AB, and O respectively; while Rh (D) positive were 94.0% and Rh (d) negative were 6.0%. The overall result is statistically insignificant (P>0.05) using Pearson Chi-square. Conclusion: The result reflects an absolute parallel relationship between baldness and ABO/Rhesus blood group systems. Thus, ordering for blood group assessment during routine hair clinic as part of ancillary investigation should be discouraged, except if other interests arise.
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    Applicability of lipid ratios in the prediction of atherogenic risks of women on combined oral contraceptive pills in North-central Nigeria
    (Wolters-Kluwer (MedKnow), 2023-06-05) Jimoh, O. S.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Bakare, T. Y.; Popoola, G. O.; Oladosu, W. O.; Grillo, E. O.; Ahmed, A.; Adeniran, A. S.
    Background: Combined Oral Contraceptive (COC) pill is associated with atherogenic and cardiovascular changes. Some service providers use individual lipid parameters to assess these changes unlike objective calculation using standard formulae. Objective: To determine and compare the atherogenic changes in women on COCs using six lipid ratios; coronary heart disease risk ratio, atherogenic index of plasma, atherogenic co-efficient, Cholesterol index, Castelli risk index I, and Castelli risk index II. Materials and Methods: A prospective, comparative study among new acceptors of contraceptives at four family planning clinics in Ilorin, North-Central Nigeria. Participants were categorized into COCs acceptors (group I, n=120) and acceptors of non-hormonal contraceptives (group II, n=120). Participants were followed up with serial lipid profiles at 0, 3 and 6 months after uptake. Atherogenic risks were calculated using six standard formulae; statistical analysis was with SPSS version 21.0 and Analysis of variance (ANOVA) was used to compare the differences of more than two means, Bonferroni Post Hoc test was used to test for specific significance within the group and p-value <0.05 was considered significant. Results: A total of 225 participants (111 COC users, 114 non-COC users) aged 19 to 48 years completed the study. Serum levels of Low-Density Lipoprotein showed a statistically significant rise among the COC users over the study period (p=0.038), especially between the third and sixth months. The lipid ratios were statistically increased using all six methods despite apparently normal lipid parameters. Conclusion: Atherogenic changes may occur in the presence of apparently normal lipid parameters among COC users; therefore, serial lipid ratio using standard method formulae is recommended.
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    Aqueous extract of Carica papaya leaves improves hyperglycemia, hyperalgesia, and oxidative stress in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
    (Biomedical Communications Group, Ibadan, Nigeria, 2022-10) Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Akintoye, O. O.; Ajibare, A. J.; Jimoh, O. S.; Owoyemi, J. O.; Ananias, E. N.; Ibiyeye, V. O.; Aboyeji, A. M.; Ojulari, L. S.
    Aqueous extract of Carica papaya leaves was investigated for its acclaimed neuroprotective activity in streptozotocin-induced diabetic peripheral neuropathy in rats. Twenty male, Wistar rats weighing between 120 & 170g were randomly assigned into four groups of five animals each. Rats in group 1 were normal, healthy rats that received normal saline 1.0ml/kg b. w. Those in group 2 (diabetic untreated) received normal saline 1.0ml/kg b. w., group 3 was treated with pregabalin 0.71mg/kg b. w. and group 4 received the aqueous leaf extract of Carica papaya 200mg/kg b. w. Plasma glucose concentration, thermal and mechanical allodynia, and biochemical biomarkers in the brain [malondialdehyde (MDA) and nitric oxide (NO)]; nerve [brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)]; and serum [superoxide dismutase (SOD) and glutathione (GSH)] were assessed. The results showed that the Carica papaya leaf-treated (group 4) rats had a significant fall in the plasma glucose level (p˂0.0001); higher pain threshold on ice cold and von Frey tests (p<0.0001); lower MDA and higher NO, BDNF, NGF, SOD and GSH levels compared to diabetic untreated (p<0.0001) and pregabalin-treated (p<0.0001) rats. Carica papaya leaf extract reduces plasma glucose, mechanical and thermal hyperalgesia, oxidative stress, and nerve damage in streptozocin-induced diabetic peripheral neuropathy in male Wistar rats.
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    Association between handgrip strength and insulin sensitivity and beta-cell function in non-diabetic, young, Nigerian adults
    (The National Institute for Medical Research in Tanzania., 2025-01) Ojulari, L. S.; Kolawole P. O.; Aliyu, A.; Yusuf, H. O.; Abraham, I. B.; Ibitoye, O. M.; Ojemuyiwa, E. Z.; Tayyib, M. R.; Sulaiman, S. E.; Ganiyu, R. A.; Ogunwale, K. A.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa
    Introduction: Insulin resistance, a condition in which cells do not respond adequately to insulin, plays a crucial role in diabetes and related metabolic disorders. This study investigated the association between handgrip strength (HGS), Insulin sensitivity, and β-cell function in non-diabetic Nigerian young adults. Materials and Methods: A total of 158 participants were used in this cross-sectional study. They were assessed for HGS, body mass index (BMI), fasting blood glucose (FBG), fasting Insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and homeostatic model assessment of β-cell function (HOMA-β). Assessments of normal distribution, descriptive statistics, subgroup analysis, Pearson's correlation, and regression models were done to analyse relationships and predict insulin and beta cell sensitivity. Multiple regression models were adjusted for confounders, and statistical significance was determined at p<0.01 or 0.05. Results: The individuals exhibited acceptable physical and metabolic well-being, with males having an average Absolute HGS (AHGS) of 59.92 kg and females having an average AHGS of 43.83 kg. The average Relative HGS (RHGS) was 2.87 for males and 2.13 for females, with an overall average BMI of 21.29 kg/m2. Strong relationships were observed between HGS (both left and right) and insulin sensitivity (measured by HOMA-IR), as well as pancreatic beta cell function (measured by HOMA-β) (p<0.01) and across other metabolic parameters (p<0.01). The differences in these associations were more evident in males than females. Male participants displayed relatively higher associations between HGS and both HOMA indices. In contrast, female individuals demonstrated weaker and statistically insignificant connections, which could result from physical, lifestyle, or hormonal disparities. Conclusion: This study is the first to show that HGS substantially indicates insulin sensitivity and beta cell function in a young, non-diabetic Nigerian population. The findings suggest that HGS could be a potential screening tool for managing insulin resistance and a feasible approach to enhancing metabolic health. Additional investigation is necessary to examine the fundamental processes and authenticate these findings in more extensive populations
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    Comparative analysis of handgrip strength and urine C-peptide creatinine ratio as biomarkers for glucose regulation in young adult females in the University of Ilorin: A cross-sectional study.
    (Nigerian Society for Experimental Biology., 2023) Ojulari, L.ekan Sheriff; Sulaiman, Swabirah E.; Ayinde, Taofeek Olanrewaju; Kadir, Eniola Riskat; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Sulaiman, H.
    Handgrip strength (HGS) is a robust biomarker predicting future disability, metabolic syndrome, and diabetes. Urinary C-peptide creatinine ratio (UCPCR) emerges as a novel, non-invasive tool under exploration for assessing beta cell function and glucose regulation. Despite their significance in gauging muscle strength, mass, and overall metabolic function, gaps remain in understanding the full extent of handgrip strength and UCPCR's efficiency. This study aimed to identify a better biomarker for glucose regulation by studying the relationship between handgrip strength, urine c-peptide creatinine ratio, and blood glucose levels in adult females. Using ELISA, the study measured handgrip strength, blood glucose levels, and urine samples. Social demographic data was obtained through standard questionnaires, and statistical analysis was done using IBM 25 SPSS software with Pearson's correlation, linear regression at P=< 0.05, and T-test. The study found that handgrip strength (HGS) had a slight non-significant positive correlation with fasting blood sugar (FBS) (P=0.386). However, there was a significant correlation between HGS and 2 hours postprandial glucose (2HPG) in both dominant and non-dominant hands (P= 0.045 vs P= 0.017). Additionally, the study found that handgrip strength in the dominant hand was significantly stronger than that in the non-dominant hand (P= 0.001). On the other hand, the urinary C-peptide creatinine ratio (UCPCR) had no significant correlations with FBS and 2HPG. Handgrip strength measurements provide an indicative approach for glucose regulation and are a better biomarker for blood glucose regulation than UCPCR
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    Evaluating the effects of heavy metals on seminal fluid antioxidant status and semen parameters among males with infertility at a tertiary centre in Nigeria
    (Karnavati University, 2024-11-15) Oladosu, W. O.; Lawani, O. A.; Oyewo, R. A.; Oderinu, K. A.; Jimoh, O. S.; Motayo, B. O.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa
    investigative tool of male infertility, has become necessary that focus should be on elucidating the aetiopathogenic causes of male fertility. This includes the impact of environmental toxic products such as levels of heavy metals that have been proposed to impact both the sperm quality and seminal antioxidant status. The study assessed how the seminal concentrations of specific heavy metals such as cadmium, lead and Iron affect the seminal fluid analysis (SFA) parameters and seminal antioxidant status of males exhibiting abnormal parameters of sperm, analysing infertile male patients consecutively in a cross‑sectional manner, with at least one abnormal SFA parameter, at a tertiary health centre. Materials and Methods: One hundred and thirty consenting males who have one or several anomalies with sperm characteristics were selected as subjects. Semen samples were collected, processed and centrifuged. The supernatants were analysed for the heavy metals using Buck Scientific 210/211VGP Flame Atomic Absorption Spectrophotometers 220GF Graphite Furnace and 220AS Autosampler and seminal Vitamins C and E, using spectrophotometric method and glutathione peroxidase, whereas catalase was analysed using ELISA method. Results: Subjects’ seminal levels of Cd, Fe and Pb were notably greater than those of controls, respectively. In addition, individuals’ levels of seminal antioxidants were noticeably lower than controls. Seminal antioxidant status and Seminal Cd, Fe and Pb were positive and negative significantly correlated with sperm count and active motility, respectively. Conclusion: Laboratory quantification of the seminal concentrations of these heavy metals in the evaluation of males with infertility, especially those still regarded as idiopathic, because of limitations of investigative tools and biomarkers, will be of clinical utility, in both the management and prevention of sperm quality deterioration
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    Ficus exasperata leaves aqueous extract influences pathophysiologic mechanisms of diabetic peripheral neuropathy in a rat model.
    (Open Science Publishers LLP, 2023-09-04) Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Ajibare, A. J.; Akintoye, O. O.; Jimoh, O. S.; Ananias, E. N.; Owoyemi, J. O.; Ibiyeye, V. O.; Ojulari, L. S.
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    Honey reverses disease progression and has anti-nociceptive and anti-inflammatory effects in a rat model of knee osteoarthritis induced by monosodium iodoacetate.
    (Elsevier, 2021-01-21) Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa; Owoyele, Bamidele Victor
    Background: Clinically, osteoarthritis manifests as joint pain with concomitant loss of joint function, which may ultimately result in a substantially reduced quality of life for the patient. Although, a lot is known about the symptom of the disease, the pathophysiology behind the structural changes is complex and poorly understood. By understanding the mechanisms driving joint tissue destruction in osteoarthritis and identifying the key factors involved, new targets for therapy are emerging that will go beyond symptomatic relief to slowing or stopping the progression of osteoarthritis. Aim: Thus, the aim of this study was to evaluate the effect of honey on disease progression, pain perception and inflammation in monosodium iodoacetate (MIA)-induced knee osteoarthritis in female Wistar rats. Methods: Thirty, twelve-month old female Wistar rats, weighing between 200 g & 250 g, were randomly divided into five groups of six animals each. Animals in group one were not induced and served as the control, while animals in groups two to five were injected with monosodium iodoacetate in the right knee. In addition, animals in group two received normal saline (1 ml/kg b.w.), group three received arthocare (glucosamine/chondroitin sulphate 6.67/8.33 mg/kg b.w.), group four received low dose honey (250 mg/kg b.w.) while group five received high dose honey (1,000 mg/kg b.w.) and were treated for twenty one days. All animals were subjected to assessment of tactile allodynia (von Frey test), acute inflammation (knee edema), and serum biomarkers: tumour necrosis factor-alpha (TNF-a), vascular endothelial growth factor (VEGF), prostaglandin E2 (PG E2) & cartilage oligomeric matrix protein (COMP) as well as histo-pathological assessment of the right knee joint. Results: Honey (at high and low doses), significantly (p < 0.05) reduced tactile allodynia on von Frey test (60 ± 20g) in animals subjected to experimental knee osteoarthritis induced by MIA. Knee edema was also significantly (p < .05) reduced by both high and low doses of honey. Low dose honey significantly (p < .05) reduced he serum levels of TNF-a (61.5 ± 22 pg/ml), VEGF (31 ± 6.1 pg/ml) and COMP (41 ± 14 ng/ml) but, had no effect on the serum level of PG E2. High dose honey on the other hand, only significantly reduced the serum level of TNF-a (87 ± 22 pg/ml) but, had no effect on the serum levels of VEGF, COMP and PG E2. However, the administration of honey did not show any significant effect on histo-pathological features of the induced osteoarthritis. Conclusion: Honey reversed disease progression and reduced pain perception as well as inflammation in MIA-induced knee osteoarthritis in female Wistar rats. However, honey had no effect on the histo-pathology of the knee joint.
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    Patterns and predictors of contraceptive uptake among women attending family planning clinic in a tertiary health facility in South-west Nigeria: a 10-year review
    (Wolters-Kluwer-Medknow., 2024-04) Jimoh, O. S.; Vaughan, T. A.; Adebayo, M. A.; Ahmed, A. K.; Sule-Odu, I. O.; Badmaasi-Abdulraheem, T. M.; Lawal, B. O.; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa
    Introduction: Contraception is a cost-effective way of reducing maternal morbidity and mortality in Sub-Saharan Africa, where its utilisation is still significantly low despite the alarming rate of unemployment and economic downturn. The choice and acceptability of different contraceptives depend on myriad factors. The study aimed to determine the patterns and predictors of contraceptive uptake among women attending a family planning clinic in a tertiary health facility in South-West Nigeria. Methods: This was a 10-year retrospective, descriptive study of the women who sought contraceptive services at the family planning clinic of Federal Medical Centre, Abeokuta, from 1 January 2011 to 31 December 2020. Relevant data were collected from the available records, coded, and analysed with the Statistical Package for Social Sciences (SPSS) version 25.0. Descriptive statistics were computed for all data, and the results were presented in tables and charts. Chi-square was used to test for significance, and a p-value < 0.05 was considered statistically significant. Results: A total number of 3,023 women accessed contraceptive services during the study period with clients between the ages of 17 and 56 years, and the highest percentage (36.3%) of contraceptive usage was between 30- 34 years, whereas 8.2% of women below the age of 25 years utilised contraceptive care services. The most common method of contraception used was implants, whereas the least common method was Bilateral Tubal Ligation (BTL). The relationship between age, parity, and level of education with the preferred methods of contraception was statistically significant (p=0.000). The lowest uptakes of contraception were recorded in 2011 and 2020. Information about contraception predominantly (71.6%) emanated from clinical personnel. Conclusion: The acceptability of different contraceptive methods is multifactorial, and the relevant stakeholders should be apprised of these critical determinants in policy formulation and implementation.
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    Testicular morphology and seminal fluid parameters of adult Wistar rats following honey administration
    (Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria., 2018-03-26) Kadir, Riskat Eniola; Ojulari, Lekan Sheriff; Ibrahim, A.; Jaji-Sulaimon, R.,; Ekundayo, O.,; Jimoh-Abdulghaffaar, Hidaayah Oluwamayowa
    Purpose: Honey has a long history of use in the traditional medical systems This objective of this study was to find out the effects of honey on quality and quantity of sperm and testicular microstructure when compared to fertility boosting drug and controls. Methods: A total number of thirty (30) matured male Wistar rats that were sexually active weighing 200 - 280g were used for this study. The animals were grouped into five as A - E. Group A was the control; Group B (standard group) was the standard group that received 0.3ml of follicle stimulating hormone (FSH) drug for 6 days; groups C, D and E received 1ml, 2ml, and 2.5ml of honey daily for 21days respectively. After 21 days of administration, the testes were removed for analysis of the sperm parameters and the histology. Results: Honey significantly improved the sperm quality and spermatogenesis rate (denser seminiferous tubule lumen) of exposed animals compared to control animals, but most improvement was seen in the standard group that received 0.3ml FSH. Also no sign of degeneration or cellular loss was observable in the testicular histo-architecture of experimental animals. Conclusion: This research showed that honey possesses some fertility boosting properties in exposed animals compared to controls and honey is not associated with increased sperm abnormalities.