Browsing by Author "Igunnu, A"
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Item Laboratory manual for practical Biochemistry(Department of Biochemistry, Faculty of Life Science, University of Ilorin, 2015-07) Akanji, M.A; Oloyede, H.O.B; Bewaji, C.O; Balogun, E.A; Malomo, S, O; Oladiji, A.T; Yakubu, M.T; Adebayo, J.O; Arise, R.O; Sulaiman, F.A; Igunnu, A; Nafiu, M.O; Salawu, M.O; Quadri, A.L; Oyegoke, R.A; Muritala, H.F; Abubakar, F.A; Modupe Olusegun; Soji-Omoniwa; Bello, O.K; Omar, SikemiPREFACE I am glad to present this edition of Laboratory Manual For Practical Biochemistry on behalf of the academic staff members of the Department of Biochemistry, Faculty of Life Sciences,University of llorin,Ilorin, Nigeria. In August 2014, when I assumed the headship of the Department of Biochemistry,the need for increased emphasis on practical aspects of Biochemistry in all areas necessitated the design of Laboratory Manual for undergraduate curriculum. The aim is to produce a 'text guide'that provides students basic appreciation of the underlying principles and practical strategies of the analytical and preparative techniques that are fundamental to the study and understanding of Biochemistry.Adequate attention has been given to those techniques that students often encounter in their practical classes. The content of this text were written in such a way that even the average students can read and understand. Regarding the organization, the book consists of seven(7)sections. Section One deals with Basic Laboratory Ethics,presenting an overview of the departmental policy. laboratory ethies and instructions about results recording and presentation. Section Two is divided into Practicals 1, 2 and 3 covering handling of experimental animals and preparation of solutions with exercises to assess students'understanding. Section Three presents Practical 4 which dwells on amino acids and proteins, highlighting their specific reactions and tests:Practical 5 is on absorption spectra of pure substances.and estimation of urinary creatinine. Practical 6 describes tests for precipitation of proteins by heating,organic acids, mineral acids, ethunol and salts of heavy metals while Practical 7 dwells on isolation, puritication and identification of amino acids and proteins employing puper chromatography,gel filtration chromatogruphy and iscelectric point determination. Section Four is on enzymes and it is divided into Pructicals 8.9.10 and 11 with experiments ranging from pH effects-on enzyme activity to specific reactivity for the recognition of some enzymes.Section Five hus two Practicals (12 and 13) on vitamins. Section Six is divided into Practicals14.15.16.17and 18 covering carbohydrate and nucleotide metabolisi presenting tests for glucose, Inctic acid, pyruvic acid and estimation of RNA while Section Seven is on lipid metabolism and is subsectioned into Pructicals 19.20,21,22. 23 and 24.covering solubility and qualitative tests on lipids. TLC.reactions of bile acids and pigments,determinution of ketone bodies and cholesteroIin serum. On behalf of academic staff members of the Department of Biochemistry,I wish to appreciate the support and approval for the publication and production of this text by the Vice-Chancellor,Prof.Abdulganiyu Ambali,OON.The efforts of all academic and technical Staff of the Department of Biochemistry is also acknowledged. Dr. R. O. Arise Ag.Head.Department of Biochemistry. University of llorin.llorin. July.2015 08052261156Item Leaf extract of Morinda lucida improves pancreatic beta-cell function in alloxan-induced diabetic rats(Taylor & Francis, 2019-09-16) Abdulkareem, A.O; Igunnu, A; Ala, A.A; Olatunji, L.AChemotherapy remains the utmost treatment for Type 1 diabetes (T1D) patients. This however, predisposes the patients to a wide range of serious complications, thus, the need for alternative therapeutic agents that target pancreatic β-cell function. This study investigated the effects of aqueous leaf extract of M. lucida (MLE) on β-cell dysfunction and atherogenic dyslipidaemia in alloxan-induced T1D in rats. Twenty-five Wister rats (156- 168g) were randomly divided into normal, diabetic, diabetic + glibenclamide (5 mg/kg), diabetic + 120 mg/kg MLE and diabetic + 240 mg/kg MLE groups (n = 5/ group). Treatments were via oral route for 14 days. Our findings revealed that, 120 mg/kg MLE significantly reduced hyperglycaemia, improved insulinaemia as well as β-cell function, and attenuated weight loss in alloxan-induced diabetic rats. The extract also attenuated (p < 0.05) atherogenic dyslipidaemia and malondialdehyde. The activities of the extract compared favourably with glibenclamide. This study suggested that, hypoglycaemic and mitigating effects of aqueous leaf extract of M. lucida on atherogenic dyslipidaemia and pancreatic β-cell dysfunction were through reduction in lipid peroxidation. The extract may therefore represent an effective source of novel drugs against TID and cardiovascular diseases. Further study is recommended, to explore the extract’s mechanism of oxidative repairItem The Role of Home Economics in Higher Institution in Nigeria(Faculty of Agriculture University of Ilorin., 2012) Igunnu, A; Gbadebo, C.TABSTRACT Home Economics Education is expected to revive the family life, help foster family solidarity, enable family members cope with the changing demands of different stages of family life and ensure wholesome relationships among family members. This review explores the role of Home Economics education in higher institutions in Nigeria. It discusses concept of Home Economics, history of Home Economics. It states the objectives of Home Economics and focuses on the role of Home Economics in higher institutions. It highlighted Home Economics areas of focus/contents and challenges facing Home Economics courses were reviewed. The researcher is of the opinion that Infusing Home Economics in higher institutions will contribute to global stability, economic, political, social development, and in fact, the world order as all these depends to a large extent on how the smallest units of individual families are morally equipped with the wherewithal to deal with challenges in an effort to make the world a better place to live in. The following recommendations were made among others. In-service education should be an integral part of the continuing efforts of government and other agencies concerned with education to promote and enhance role of Home Economics teacher's effectiveness and there should be awareness creation on the importance of Home Economics in higher institutions of learning. This review may be beneficial to policy makers and educators in their search of strategies for improving Home Economics as a course in higher institutions.