Browsing by Author "Hamid, Abdulmumeen Amao"

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    Chemical constituents and antiproferative properties of Turraea vogelli Hook. f. ex. Benth leaves
    (The Library and Publications Committee, University of Ilorin, Nigeria, 2015-06-01) Hamid, Abdulmumeen Amao; Aiyelaagbe, O. Olapeju; Oguntoye, Stephen O.; Negi, Arvind Singh; Zubair, Marili F.
    Ethyl acetate and methanol extracts of Turraea vogelli leaves exhibited cytotoxic activity on leukaemia carcinoma K562 with IC50 values 85.00 and 85.22 ug/mL respectively. Isolation of the extracts afforded tetradec-7-enoic acid (1), pentadec-1-ene (2), ethyl tridec-7-enoate (3), Beta-sitosterol (4) and stigmasterol (5). The structures of these compounds were characterised by IR, 1D and 2D NMR and Mass Spectroscopy, and supported with literature data. Compounds 1 and 4 exhibited antiproliferative activity against K562 tumor cell lines with 1C50 of 57.27 and 27.56 ug/mL respectively. All isolated compounds exhibited low cytotoxicity against WRL and MCF - 7 tumor cell lines
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    Preliminary Phytochemistry and Antimicrobial Properties of Baleria opaca
    (Chemical Society of Nigeria, Kwara Chapter, 2011-09-18) Hamid, Abdulmumeen Amao; Aiyelaagbe, Olapeju O.; Yusuf, A. A.
    The preliminary phytochemical studies of Baleria opaca (whole plant) extracts revealed the presence of saponnins, tannins, glycosides, alkaloids and anthraquinones, but reducing sugars and flavonoids were not detectedin the extracts. The hexane, ethyl acetate and methanol extracts effectively inhibited the growth of tested bacteria and fungi at different concentrations respectively. The methanol extract exhibited higher antibacterial properties than hexane and ethyl acetate extracts on Staphylococcus aureus and Bacillus subtilis (gram positive), Escherichia coli, Pseudomonas aeruginosa, Salmonellae typhii and Klebsiellae pneumonae (gram negative). All the extracts also exhibited significant antifungal properties on Candida albicans, Aspergillus niger, Rhizopus stolon, penicillum notatum, Tricophyton rubrum and Epidermophyton floccosum at concentrations between 25 and 200 mg/mL.