Browsing by Author "Ghazali, K. O."
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Item The effects of Moringa Oleifera on lipid profile status, heart histology, and liver histochemistry in adult Wistar rats(Wolters Kluwer - Medknow, 2017-04-10) Akinlolu, A. A.; Bayode, E. O.; Ghazali, K. O.; Ameen, M. O.Background: Moringa oleifera’s leaves are globally used for nutritional and medicinal purposes. We evaluated lipid profile status, heart and liver histology, and the activities of alanine and aspartate transaminases of the liver in M. oleifera‑treated adult Wistar rats. Materials and Methods: Twenty‑four adult male Wistar rats were employed in the study. Rats of control Group I received physiological saline while rats of Groups II–IV received 250, 500, and 750 mg/kg bodyweight of methanolic extract of M. oleifera, respectively, for 21 days. Results: No gross morphological or behavioral anomalies were observed in rats of Groups I–IV. Histological examinations showed normal histoarchitecture of the heart in Group I and the liver of Groups I–III. Comparative histological analyses showed dose‑dependent increased nucleated cells in heart tissues of rats of Groups II–IV than those of Group I. Furthermore, histological evaluations showed hypertrophy of central vein of the liver in rats of Group IV when compared to Group I. Statistical analyses showed dose‑dependent non significant higher mean levels (P > 0.05) of total cholesterol and triglycerides in the sera of rats of Groups II–IV compared to rats of Group I. Evaluations of levels of alanine and aspartate transaminases showed a statistically significant higher mean values (P < 0.05) in Group II, but statistically nonsignificant higher mean values (P > 0.05) in Groups III–IV compared to Group I. Conclusions: No significant adverse effects on lipid profile status, heart histology, and liver histochemistry were observed in M. oleifera‑treated rats.Item Spondias mombin promotes gastric mucosa and lipid profile status in gastric ulceration(Brazilian Society of Anatomy and Pan-American Association of Anatomy, 2014-08-10) Akinlolu, A. A.; Ghazali, K. O.; Ameen, Mubarak; Odewabi, A. O.Introduction: Spondias mombin has been reported to possess medicinal properties. Material and Methods: This study evaluated the anti-ulcer properties of Spondias mombin. Rats of Group I received physiological saline only while 40mg/kg/bodyweight of Indomethacin (an ulcerogen) was administered to rats of Groups II – VI. Four hours after administrations of the ulcerogen; rats of Groups III – VI were treated daily with oral administrations of 250, 500 and 1000mg/kg/bodyweight of Spondias mombin bark extract and 40mg/kg/bodyweight of Omeprazole respectively for four days. Rats were euthanized on Days 1 (Group II) and 5 (Groups I and III – VI); stomach and liver samples were removed for evaluations of gastric acidity, histo-pathological and lipid profile status. Results: Analyses of gastric acidity and lipid profile status in the stomach and liver samples of rats of Group II showed statistically significant higher levels (P≤0.05) of gastric acidity, total cholesterol, low density lipoprotein-cholesterol and triglycerides but lower high density lipoprotein-cholesterol levels (P≤0.05) when compared to rats of Groups I, and III – VI. Histopathological evaluations showed dose-dependent restorations of stomach and liver histology to pre-ulceration states in rats of Groups III – VI. Conclusions: This study concluded that Spondias mombin administrations promoted histo-pathological restorations of the stomach and liver; and lipid profile status of male wistar rats in Indomethacin – induced gastric ulceration.