Browsing by Author "Emmanuel Oluwamuyiwa Gabriel"

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    Metformin and vitamin D combination therapy ameliorates type 2 diabetes mellitus‐induced renal injury in male Wistar rats
    (Naunyn-Schmiedeberg's Archives of Pharmacology, 2024-09-30) Halimat Amin Abdulrahim; Emmanuel Aduragbemi Owootori; Adeyemi Fatai Odetayo; Joshua Damrah Bulus; Fatimoh Bolanle Jimoh; Emmanuel Oluwamuyiwa Gabriel; Iyanu Feranmi Odiete; Luqman Aribidesi Olayaki
    Diabetic kidney disease is a major microvascular diabetes mellitus (DM) complication clinically associated with a gradual renal function decline. Although metformin is a common drug for managing DM, however, monotherapy treatment with any antidiabetic drug will necessitate dosage increment since type 2 DM (T2DM) deteriorates over time due to the increasing pancreatic β-cell dysfunction and will eventually require a combination therapy approach with another antidiabetic medica- tion. Vitamin D is a food supplement that has been proven to have antidiabetic and reno-protective activities. Hence, we explore the combination of vitamin D and metformin on T2DM-induced renal dysfunction. Thirty male Wistar rats were randomized into fve (5) groups: control, diabetes untreated, diabetics treated with metformin, vitamin D, and vitamin D+metformin. Vitamin D and metformin signifcantly reversed DM-induced hyperglycemia, electrolyte imbalance, and dyslipidemia. Also, vitamin D and metformin reversed T2DM-induced increase in serum creatinine and urea and renal lactate, LDH, and oxido-infammatory response. These observed alterations were accompanied by an increase in proton pump activities and modulation of Nrf2/Nf-κB and XO/UA signaling. This study revealed that vitamin D and/or metformin ameliorated T2DM-induced renal injury.