Browsing by Author "Durotoye, I.A."

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    Atypical chronic myeloid leukaemia in an adolescent nigerian: a case report and review of the literature
    (College of Medicine, Ambrose Alli University, 2017) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Adepoju, A.M.
    Abstract: Atypical chronic myeloid leukaemia (aCML) is a rare subtype of CML which is now regarded as a separate clinical entity and classified among the Myeloproliferative/myelodysplasic syndromes. It lacks the Philadelphia chromosome and BCR-ABL fusion gene found in the classical CML. We report a case of aCML which was diagnosed and managed at the Haematology Department of the University of Ilorin Teaching Hospital, Ilorin. Full blood count showed anaemia, leucocytosisand presence of various forms of myeloid cells with dysplastic features. Bone marrow aspiration done also showed myeloid hyperplasia with dysplastic changes in the myeloid cells. There was poor outcome in the patient. This case illustrates the importance of full haematological investigations of suspected CML cases so that the diagnosis of a CML will not be missed or passed for CML as this could influence choice of treatment and prognosis of patients. There is need for improved diagnostic facilities in tertiary health institutions in the country if we must achieve proper diagnosis and characterization of cases of aCML.
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    Changing pattern of haematological malignancies in Ilorin, Nigeria: A 10 year retrospective review of 181 cases
    (Ambrose Alli University, 2016) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Akinwumi, O.O.
    Abstract The global burden of cancer has been reported to be on the increase and haematological malignancies (HM) are not exceptions to this observed trend. The aim of this study was to carry out a retrospective analysis of all cases of HM seen at the University of Ilorin Teaching Hospital, Ilorin and document the current pattern of HM and compare with previous reports from Nigeria and elsewhere. Materials used for the study were obtained from the Records Cancer Registry of the University of Ilorin Teaching Hospital. A total of 181 cases of HM were diagnosed and managed within the study period constituting 8.1% of all cancer cases and 0.2% of all hospital admissions. The ages of patients with HM ranged from 7 months to 80 years. There were 116 (64.1%) males and 65 (35.9%) females. The various HM recorded in the study were: ALL 17(9.4%), AML 23(12.7%), CLL 33(18.2%), CML 46(25.4%), NHL 33(18.2%), HL 7(3.9%), BL 2(1.1%) and MM 20(11.0%). CML was the commonest HM observed in this study. NHL was the commonest lymphoma encountered constituting 82.5% of all the lymphoma cases. This study demonstrated that haematological malignancies are common in this environment. Availability of improved diagnostic facilities, improved blood transfusion services, early presentation and better referral system from other health facilities to our centre may have contributed to the improved mean survival of patients with HM observed in this study.
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    Clinico-Laboratory Features of Multiple Myeloma in Selected Patients at University of Ilorin Teaching Hospital, North Central Nigeria
    (University of Ilorin, 2019) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K.; Sanni, E. O.; Owoeye, O.A.
    Abstract Multiple myeloma is an haematological disorder characterized by clonal proliferation of bone marrow plasma cells with production of increased amounts of monoclonal immunoglobulins which are detectable in blood and/or urine. The aim of the study was to describe the clinical and laboratory characteristics as well as treatment outcome in multiple myeloma patients diagnosed and managed at the Haematology Department of the University of Ilorin Teaching Hospital (U.I.T.H), Ilorin, North Central Nigeria, between 1st January 2008 and 31st December 2018. The study materials included bone marrow registers from the department and case folders of all multiple myeloma patients diagnosed within the study period. Relevant data including socio-demographic characteristics of patients, clinical features at presentation and laboratory tests results were extracted, documented and analyzed. Diagnosis was made in all patients based on the presence of major and/or minor criteria as described by the International Myeloma Working Group guidelines. Fifty eight (58) patients were diagnosed with multiple myeloma comprising of 31 males and 27 females (M:F ratio = 1.15:1). The median age of patients was 62.6 years (range = 39 – 85 years), and the most common presenting features included back pains (86.2%), bone pains (69%), inability to walk (67.2%) and anaemia (67.2%). High erythrocyte sedimentation rate > 30mm/Hr was seen in all patients (100%), Immunoglobulin G (Ig G) was the commonest monoclonal immunoglobulin demonstrated on serum protein electrophoresis (82.8%), and “punched out” osteolytic bone lesion on X-rays was demonstrated in 79.3% of cases. In resource-limited settings such as ours, the diagnosis and monitoring of patients with multiple myeloma still rely on the clinical and laboratory features of the disease to a large extent, hence the need for haemato-oncologists and physicians to be conversant with these features.
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    Clinico-Pathologic features and outcome of Chronic Lymphocytic Leukemia in Ilorin, North Central Nigeria
    (College of Health Sciences, University of Ilorin, 2020) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K.; Owoeye, O.A.; Sanni, E.O.
    Abstract: A retrospective analysis of all patients that were diagnosed and managed for Chronic lymphocytic Leukemia(CLL) in the Department of Haematology of University of Ilorin Teaching Hospital, Ilorin between 1st January 2005 and 31st December 2018 was carried out with the aim of characterizing the clinical, haematological and prognostic features as well as outcome in the patients. A total of 39 patients were reviewed consisting 25(64.1%) males and 14(35.9%) females giving a M:F ratio of 1.6:1. The median age of patients at diagnosis was 65.5 years and the highest prevalence was found in the 60 – 69 years age group. The commonest symptoms at presentation were night sweats (59.0%), Body weakness (51.3%), fever (41.0%), and weight loss (41.0%) while the commonest signs included lymphadenopathy in all patients (100%), splenomegaly (87.2%), pallor (53.9%) and hepatomegaly (46.2%). The mean values of haematological parameters were: Packed cell volume (28.6%), Haemoglobin concentration (9.4g/dL), Total white blood cell count (87.6 x 109/L), Absolute lymphocyte count (55.8 x 109/L) and platelet count (134.8 x 109/L). The majority of the patients (94.9%) were diagnosed with advanced disease (Rai stage III and IV) while only 2(5.1%) had Rai stage II and none in Rai stage 0 – I. Chlorambucil-based regimen was used in 71.8% of patients, and only 2 patients had Rituximab as part of their treatment regimen. The clinical presentation, haematological features and disease outcome observed in our study was similar to what had been reported in Nigeria and other parts of the world.
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    Current Trend of Transfusion Transmissible Infections among Voluntary Blood Donors in North Central Nigeria
    (College of Health Sciences, University of Ilorin, 2021-07) Durotoye, I.A.; Salaudeen, A.G.; Sanni, E.O.; Durowade, K.A.; Babatunde, A.S.; Olawumi, H.O.; Akande, T.M.; Musa, I.O.
    Blood transfusion is an integral part of modem medicine which had saved many lives which would have been lost as a result of lack of blood. Although blood is needed for survival, it can also be a medium for the transmission of harmful infectious diseases. This study evaluated current trend of transfusion transmissible infections among voluntary blood donors in Nigeria. This was a descriptive community-based study involving 600 prospective voluntary blood donors among staff and students of 5 tertiary institutions in Kwara and Kogi States. Hepatitis B surface antigen and Hepatitis C antibodies were screened for using Hepatitis B Virus Surface Antigen Bio-Inteco ELISA KIT, and Anti-HCV Bio-Inteco ELISA KIT, respectively. Screening for HIV was done with Enzyme immunoassay method using Human Immunodeficiency Virus (HIV) 1+2 Antigen Antibody ELISA KIT, product of Bio-Inteco HIV Diagnostics, UK. Testing for Syphilis was carried out using Rapid Plasma Reagin (RRR) test. Statistical analysis was done with IBM SPSS version 20. Level of significance was set at p< 0.05 The mean age of the subjects was 21.98 ± 5.17 years. Two thirds of the prospective blood donors were within the second decade of life and more than half were males. The prevalence of Hepatitis B among subjects were 4.7%, Hepatitis C,0.2%, HIV 1% and Syphilis 0%. The prevalence of hepatitis B and HIV were relatively high compared to Hepatitis C and Syphilis among voluntary blood donors, although lower than the prevalence among general population in Nigeria. In order to improve on blood transfusion safety, there is a need to increase public awareness on vaccination for hepatitis B virus, Quality control of screening methods and rational use of Blood.
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    Determination of Haemoglobin Concentration of Prospective Voluntary Blood Donors using Digital Haemoglobinometer in North Central Nigeria
    (College of Health Sciences, Ambrose Alli University, Ekpoma, 2020-06) Durotoye, I.A.; Salaudeen, A. G.; Babatunde, A. S.; Durowade, K. A.; Sanni, E. O; Akande, T. M.; Olawumi, H. O.; Musa, O. I.
    Haemoglobin estimation is one of the most important criteria in donor selection so as to safeguard the health of donors. To achieve this, reliable and cost-effective methods should be employed during blood donation drive. The aim of this study was to determine the haemoglobin concentration of voluntaryblood donors using digital haemoglobinometer. This study was a prospective, community based conducted in five tertiary institutions in Kwara and Kogi States. Blood samples were taking from consecutive male and female donors within the age of 15-63 years following blood donation campaign. Assessment of haemoglobin concentration was done using Diaspect haemoglobinometer. A total of 905 students and staff of five tertiary institutions participated in this study. The mean age of the respondents was 21.98±5.17 years and 96.3% were below 30 years of age. The mean, median, and standard deviation of heamoglobin level were 13.22, 13.20, and 1.62 g/dl respectively. Using the WHO haemoglobin cut –off value of 12.5g/dl for donor selection, about 64.1% of the prospective donor had haemoglobin value of greater. There was a statistically significant difference between haemoglobin level of male and female donors (p=0.001). This study revealed that 64% of blood donors had heamoglobin concentration greater than 12.5g/dl and were fit for blood donation. Students of tertiary institutions could therefore be encouraged for regular blood donation to meet WHO vision 2020 towards attaining 100% voluntary non-remunerated blood donors
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    Evaluation of the Clinico-haematological Characteristics and Pattern of Presentation of Acute Myeloid Leukemia in Ilorin, North Central Nigeria.
    (Ambrose Alli University, Ekpoma, 2020) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K.; Owoeye, O.A.; Sanni, E.O.
    Acute myeloid leukemia (AML) is a malignant haematologicaldisorder of the myeloid lineage in the bone marrow resulting from clonal proliferation of haemopoietic progenitor cells with accumulation of myeloblasts in the blood, bone marrow and tissue infiltration. The aim of this retrospective study was to determine the pattern of presentation, clinical features and haematological parameters of AML patients diagnosed at the Haematology Department of U.I.T.H, Ilorin between 1" January 2008 and 31“ December 2018. The study materials included Bone marrow registers from the department and case folders of all AML patients diagnosed within the study period. Relevant data including socio-demographic characteristics of patients, clinical features at presentation and laboratory tests results were extracted, documented and analyzed. Diagnosis of AML was made based on the findings of 20% blasts in the bone marrow and/or peripheral blood and classified using FAB classification criteria.There were forty-six patients and their median age at diagnosis was 20.6 + 15.9 years.The highest prevalence of the disease was found in the 11 — 20 years age group.The most common presenting symptoms were fever (91.3%), pallor (84.8%), bleeding diasthesis (52.2%), and body weakness (45.7%).The mean+SD values of haematological parameters in the patients wer—e PCV (19.9+5.8%), Hb cone. (6.6+1.9 g/dL), Total WBC (48.1+54.8 x 10’/L) and Platelet Count (39.6+24.0 x 10’/L).The commonest subtype of AML in our study was M4 which was seen in 26 (56.5%) patients, followed by M5 observed in 10 (21.7%) patients. In resource-limited settings such as ours, the diagnosis and monitoring of patients with AML still rely on the clinical and laboratory features of the disease to a large extent, hence the need for Haemato-oncologists and Physicians to be conversant with these features.
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    Evaluation of the Indications and Diagnostic Value of Bone Marrow Examination in Haematological Disorders in Ilorin Nigeria: A Review of 496 Cases
    (College of Health Sciences, University of Ilorin, 2020) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K; Owoeye, O.A.
    Abstract: Bone marrow examination, either in the form of aspiration or biopsy, is an invasive procedure which is relatively safe and is still being performed routinely in the investigation and diagnosis of various malignant and non-malignant haematological disorders. The aims of this study were to evaluate the role of bone marrow examination in the investigation and diagnosis of haematological disorders, and the pattern of disorders diagnosed by bone marrow examination in our centre. This study was a retrospective review of all cases of bone marrow examinations which were carried out at the Haematology department of U.I.T.H Ilorin between 1st January 2005 and 31st December 2018. Case folders of all patients who had bone marrow examination done during the study period, Bone marrow aspiration and biopsy registers from Haematology department, Bone marrow reports and Full blood counts (FBC) results were retrieved and analyzed. Relevant clinical information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. A total of 496 cases had BME performed during the study period. The patients comprised 276 (55.8%) males and 220 (44.2%) females with a M:F ratio of 1.3:1. Their median age was 38.5 years (age range 16 months and 85 years). Pathological marrow with diagnosis on BME was found in 441 (88.9%) while normal marrow (negative for any pathologic condition) was seen in 55 (11.1%) of patients. The leukemias (acute and chronic) were the commonest haematological disorders found on bone marrow examination, constituting 37.8% of cases. Unexplained anaemia was the commonest clinical feature at presentation necessitating bone marrow examination. Bone marrow examination is still very useful as a diagnostic tool in the hand of Haematologists in the investigation and diagnosis of various haematological disorders, and is relatively safe to perform even with presence of thrombocytopenia.
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    Evaluation of the Indications and Diagnostic Value of Bone Marrow Examination in Haematological Disorders in Ilorin Nigeria: A Review of 496 Cases.
    (College of Health Sciences, University of Ilorin., 2020) Babatunde, A.S.; Durotoye, I.A.; Shittu, A.O.; Omokanye, K.O.; Ogunfemi, M.K.; Owoeye, O.A.
    Abstract Bone marrow examination, either in the form of aspiration or biopsy, is an invasive procedure which is relatively safe and is still being performed routinely in the investigation and diagnosis of various malignant and non-malignant haematological disorders. The aims of this study were to evaluate the role of bone marrow examination in the investigation and diagnosis of haematological disorders, and the pattern of disorders diagnosed by bone marrow examination in our centre. This study was a retrospective review of all cases of bone marrow examinations which were carried out at the Haematology department of U.I.T.H Ilorin between 1st January 2005 and 31st December 2018. Case folders of all patients who had bone marrow examination done during the study period, Bone marrow aspiration and biopsy registers from Haematology department, Bone marrow reports and Full blood counts (FBC) results were retrieved and analyzed. Relevant clinical information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. A total of 496 cases had BME performed during the study period. The patients comprised 276 (55.8%) males and 220 (44.2%) females with a M:F ratio of 1.3:1. Their median age was 38.5 years (age range 16 months and 85 years). Pathological marrow with diagnosis on BME was found in 441 (88.9%) while normal marrow (negative for any pathologic condition) was seen in 55 (11.1%) of patients. The leukemias (acute and chronic) were the commonest haematological disorders found on bone marrow examination, constituting 37.8% of cases. Unexplained anaemia was the commonest clinical feature at presentation necessitating bone marrow examination. Bone marrow examination is still very useful as a diagnostic tool in the hand of Haematologists in the investigation and diagnosis of various haematological disorders, and is relatively safe to perform even with presence of thrombocytopenia.
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    Haematological Parameters of Normal Pregnant Women During Antenatal Clinic Booking in Ilorin, North Central Nigeria
    (Ambrose Alli University, 2017) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Adesina, K.T.; Sani, M.A.; Nyamgee, A
    Alterations in the values of some haematological parameters like packed cell volume and haemoglobin concentration during pregnancy have been reported to significantly influence pregnancy outcome. The aim of this study was to determine the values of haematological parameters in apparently healthy pregnant women during the antenatal clinic booking visit at the University of Ilorin Teaching Hospital, Ilorin, North central Nigeria. A total of 298 apparently healthy pregnant women who presented for antenatal care booking and satisfied the inclusion criteria were included in the study. There were 64 (21.5%) women in first trimester, 146 (49.0%) women in second trimester and 88 (29.5%) in third trimester; and were aged between 22 and 42 years. Packed cell volume, haemoglobin concentration, Red cell count, mean haemoglobin concentration, mean corpuscular volume, mean corpuscular haemoglobin concentration, Total white blood cell count and differentials, Platelet count and erythrocyte sedimentation rate were carried out in the subjects. The overall mean values and SD of the pregnant women for the haematological parameters were as follows: PCV (32.76±2.18%), Hb (10.82±0.77g/dl), RBC (3.87±2.32 x1012/L), MCH (28.08±2.06 pg), MCV (85.16±5.82 fl), MCHC (33.01±1.05 g/dl), TWBC (7.35±2.62 x109/L), Platelet count (192.15±62.80 x109/L) and ESR (34.07±16.85 mm/hr). There were statistically significant differences in the mean values of PCV, MCH and MCV with increasing gestational age (p<0.05). Conclusion: The present study provides a baseline data on the haematological values in pregnancy in the North central zone of the country on which further large scale studies in future may be based. This study will also be of immense benefit in the monitoring of pregnant women to determine those at risk for timely intervention thereby improving pregnancy outcome.
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    Knowledge and Perception of Sickle Cell Disease among Senior Secondary School Students in Ilorin Metropolis
    (College of Health Sciences, University of Ilorin, 2013) Durotoye, I.A.; Salaudeen, A. G.; Babatunde, A.S.; Bosah, E. C.; Ajayi, F. D.
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    PAI-1 and tPA as markers of severity among pre-eclamptics in a tertiary institution in north central Nigeria
    (University of Ibadan, 2016) Oladosu - Olayiwola, O.R.; Olawumi, H.O.; Babatunde, A.S.; Ijaiya, M.; Durotoye, I.A.; Biliaminu, A.S.; Ibraheem, R.M.; Ogunfemi, M.K.
    Objectives: Endothelial dysfunction contributes to the pathogenesis of pre-eclampsia as well as increased production of some factors such as tissue plasminogen activator (tPA) and plasminogen activator inhibitor type1 (PAI-1). These factors are said to be biomarkers of pre-eclampsia but their role in assessing the severity of pre-eclampsia is under-reported. Methodology: A cross-sectional study involving 85 subjects with pre-eclampsia. They were classified clinically as having mild or severe pre-eclampsia using ACOG classification. Blood and urine samples were collected for determining tPA, PAI-1, D-dimer and proteinuria in the two groups. Clinical and laboratory values were compared using the IBM®SPSS 20.0 (2011) soft ware packages. Results: The mean age of the respondents was 29.9±5.2 years. Forty-five (52.9%) of the subjects had severe pre-eclampsia while 40(47.1%) had mild pre-eclampsia. The median values of tPA and PAI-1 of subjects with severe pre-eclampsia were significantly higher than the corresponding values in subjects with mild preeclampsia (each p=0.001). There was a positive correlation between each of the tPA and PAI-1 levels with the degree of severity of pre-eclampsia (p=0.001 each). Conclusion: Fibrinolytic proteins like tPA and PAI-1 are useful in assessing the severity of pre-eclampsia.
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    Pattern of Childhood Malignancies in Ilorin, Nigeria: Challenges and Strategies for Management in a Tertiary Health Institution
    (Hindawi Publishing Corporation, 2015) Babatunde, A.S.; Gobir, A.A.; Adeboye, M.A.N.; Adebayo-Oloko, A.; Durotoye, I.A.
    Objective: The study was carried out to document the pattern of childhood malignant tumors which were diagnosed at the University of Ilorin Teaching Hospital, Ilorin, and compare with previous reports from other parts of Nigeria and elsewhere and also highlight the challenges and strategies for effective management of these diseases in our environment. Methods: A ten year retrospective analysis of all cancers diagnosed in children below the age of 18 years at the study centre between January 2000 and December 2009 was carried out. Case folders of all children diagnosed with malignant tumors within the study period were retrieved from the Cancer Registry Department of the Hospital and were analyzed with respect to age, gender, morphological or histological type of malignancy, extent of disease, treatment modality, and survival outcome. Results: Ninety nine (99) children were diagnosed with various malignancies during the study period. Sixty seven (67; 67.7%) were boys and 32 (32.3%) were girls giving a male to female ratio of 2:1. There were 22 cases (22.2%) recorded in children aged below 4 years and 72 cases (72.7%) were diagnosed in children between 4 -14 years. Lymphomas were the most prevalent malignancies encountered accounting for 54 cases (54.5%), Burkitt’s lymphoma constituted 43 (79.6%) of all lymphoma cases. The distribution of the five foremost malignancies recorded were as follows: Burkitt’s lymphoma (43 cases), Nephroblastoma (10 cases), Retinoblastoma (8 cases), Non Hodgkin’s lymphoma (7 cases) and Acute leukaemias (5 cases). Other malignancies included Osteogenic sarcoma (5), Hodgkin’s lymphoma (4), and 2 cases each of primary liver cell carcinoma, neuroblastoma, rhabdomyosarcoma and nasopharyngeal tumor. Conclusion: The distribution of the various childhood malignant tumors recorded in this study is similar to the pattern reported in previous studies from Nigeria and other countries. However, there appears to be a lower prevalence of leukemia recorded in this study compared to the earlier findings. The challenges which were identified in the diagnosis, management and overall outcome of our patients included limited number of diagnostic tools, late presentation in the hospital, high patient default rate, poverty, and shortage of chemotherapeutic drugs.
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    Pattern of Haematological Changes in Patients with Chronic Kidney Disease Attending Nephrology Clinic in a Tertiary Hospital in North Central Nigeria
    (Amber Publication Ltd, 2020) Sanni, E.O.; Olawumi, H.O.; Durotoye, I.A.; Babatunde, A.S.; Shittu, A.O.; Biliaminu, S.A.; Omokanye, K.O.; Ogunfemi, M.K.; Akinwumi, O.O.; Oyedepo, D.; Dane, S.
    Introduction: The impact of the disease of the kidney is enormous in developing countries like Nigeria. With the increasing use of erythropoietin stimulating agents in anaemic patients with CKD, there is a need to evaluate the changes in haematological parameters in these patients. This study assessed the haematological changes in patients with known chronic kidney disease. Materials and methods: Our research was a cross-sectional study that assessed and compared the haematologic parameters of 113 patients who had established chronic kidney disease and 113 -healthy controls who were age–and sex-matched. The full blood count (FBC) was determined by SysmexKX21(Sysmex, Japan). The test of significance was set at a P- value of <0.05. Results and Discussion: The mean age of patients with CKD was 55.00 + 15.37 years, whilst that of controls was 52.73±13.59 years. (p-value 0.240) The values of the mean of the Hb and RBC among the patients were 9.69+ 2.25g/dl and 3.62 ± 0.92 x 1012/L respectively and were found to be significantly lower than that seen among controls (13.62 ± 1.45 and 4.94 ± 0.62 respectively) with a P-value<0.001. Significantly higher values of the mean WBC and platelet count were found in the patients when compared with the control participants (p-value<0.001). A significant proportion of our patients had microcytic hypochromic anaemia (32%). Conclusion: Careful evaluation of the cause of anaemia and urgent interventions are needed in the managements of these patients.
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    Pattern of neurological complications of chronic myeloid leukaemia in Ilorin, Nigeria: A ten year review
    (Faculty of Clinical Sciences, College of Medicine, Ambrose Alli University, 2018) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Sanni, E.O.; Oyeleke, S.A.
    Aim and Objective: The study was carried out to document the pattern of neurological complications seen in patients with chronic myeloid leukemia who were managed at the University of Ilorin Teaching Hospital, Ilorin and compare with previous reports from other parts of Nigeria and elsewhere. Materials and Methods: A ten year retrospective analysis of all cases of CML managed at the study centre between January 2006 and December 2015 was carried out. Case folders of all patients diagnosed with CML during the study period, and the Malignancy registers of the Haematology department were retrieved and analyzed. Relevant information retrieved included age, gender, clinical features at presentation, laboratory investigations, treatment regimen, and survival outcome among others. Results: Thirty six (36) patients were diagnosed with CML during the study period. There were 21 (58.3%) males and 15 (41.7%) females, giving a male: female ratio of 1.4:1.The mean age of the patients at diagnosis was 37.5 years (range, 11-75 years). Nine (25%) patients presented with various forms of neurological complications and the mean WBC count in them was 383.2 x 109/L (280.5 601.0 x 109/L). Auditory complications were the commonest neurological deficits found in 6(66.7%) of the 9 patients with neurological manifestations. Conclusion: The neurological complications recorded in this study were similar to those reported in previous studies from Nigeria and other countries. These complications need to be looked for at presentation and adequately characterized as their presence could significantly influence the prognosis of the disease and decisions on management modalities.
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    Prevalence of Anaemia among Pregnant Women at Antenatal Care Booking in Ilorin, North Central Nigeria
    (College of Health Sciences, University of Ilorin, 2017) Babatunde, A.S.; Olawumi, H.O.; Durotoye, I.A.; Shittu, A.O.; Adesina, K.T.; Sanni, M.A.
    Abstract: Anaemia is a global health problem which commonly affects women and children most especially in the developing countries. Anaemia in pregnancy is the most common haematological condition encountered among pregnant women in most developing countries including Nigeria. This prospective study was carried out to determine the red blood cell indices (PCV, Hb, RBC, MCH, MCV, MCHC) and the prevalence of anaemia among pregnant women attending the University of Ilorin Teaching Hospital, Ilorin. A total of 298 women who presented for booking at the antenatal clinic at different levels of pregnancy were enrolled in the study. There were 64 (21.5%) women in first trimester, 146 (49.0%) women in second trimester and 88 (29.5%) in third trimester The mean age of the women was 25.8±3.2 years, and their ages ranged between 18-42 years. One hundred and eighty pregnant women had haemoglobin concentration < 11.0g/dl giving a prevalence rate of anaemia of 60.4%. Mild anaemia was found in 105 (58.3%), moderate anaemia in 72 (40.0%) and anaemia in 3(1.7%) of the pregnant women. There was significant correlation between anaemia and gestational age, parity and level of education at booking. This study indicated presence of high prevalence of anaemia in pregnancy and there is need for appropriate interventional strategies to be put in place so as to reduce prevalence of anaemia and improve pregnancy outcome in our environment